Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma

Lung adenocarcinomas frequently harbour KRAS mutations, of which a subset are characterized by co-mutation of KEAP1. Here the authors show, in mice, that Kras G12D mutant tumours are metabolically distinct, with a bronchiolar cell-of-origin.

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Autores principales:	Sarah A. Best, Sheryl Ding, Ariena Kersbergen, Xueyi Dong, Ji-Ying Song, Yi Xie, Boris Reljic, Kaiming Li, James E. Vince, Vivek Rathi, Gavin M. Wright, Matthew E. Ritchie, Kate D. Sutherland
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ac2538b3a39145fe917c923569a787a5
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spelling	oai:doaj.org-article:ac2538b3a39145fe917c923569a787a52021-12-02T17:01:38ZDistinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma10.1038/s41467-019-12164-y2041-1723https://doaj.org/article/ac2538b3a39145fe917c923569a787a52019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12164-yhttps://doaj.org/toc/2041-1723Lung adenocarcinomas frequently harbour KRAS mutations, of which a subset are characterized by co-mutation of KEAP1. Here the authors show, in mice, that Kras G12D mutant tumours are metabolically distinct, with a bronchiolar cell-of-origin.Sarah A. BestSheryl DingAriena KersbergenXueyi DongJi-Ying SongYi XieBoris ReljicKaiming LiJames E. VinceVivek RathiGavin M. WrightMatthew E. RitchieKate D. SutherlandNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sarah A. Best Sheryl Ding Ariena Kersbergen Xueyi Dong Ji-Ying Song Yi Xie Boris Reljic Kaiming Li James E. Vince Vivek Rathi Gavin M. Wright Matthew E. Ritchie Kate D. Sutherland Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma
description	Lung adenocarcinomas frequently harbour KRAS mutations, of which a subset are characterized by co-mutation of KEAP1. Here the authors show, in mice, that Kras G12D mutant tumours are metabolically distinct, with a bronchiolar cell-of-origin.
format	article
author	Sarah A. Best Sheryl Ding Ariena Kersbergen Xueyi Dong Ji-Ying Song Yi Xie Boris Reljic Kaiming Li James E. Vince Vivek Rathi Gavin M. Wright Matthew E. Ritchie Kate D. Sutherland
author_facet	Sarah A. Best Sheryl Ding Ariena Kersbergen Xueyi Dong Ji-Ying Song Yi Xie Boris Reljic Kaiming Li James E. Vince Vivek Rathi Gavin M. Wright Matthew E. Ritchie Kate D. Sutherland
author_sort	Sarah A. Best
title	Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma
title_short	Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma
title_full	Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma
title_fullStr	Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma
title_full_unstemmed	Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma
title_sort	distinct initiating events underpin the immune and metabolic heterogeneity of kras-mutant lung adenocarcinoma
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ac2538b3a39145fe917c923569a787a5
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Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma

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