Randomized Controlled Trial of Tranexamic Acid’s Effect on Bleeding Length: A Study on DMPA Users with Abnormal Uterine Bleeding Who Receive Low-Dose Oral Contraceptive Pill

ABSTRACT Background: Contraceptive injection is the most common contraception used in Indonesia. Among the contraceptive injections, depomedroxy progesterone acetate (DMPA) is the most effective method with pregnancy rate of 0,3 pregnancy in 100 women annually. Abnormal uterine bleeding (AUB) is a...

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Autores principales:	Rabiah Adawiyah, Inu Mulyantoro, Julian Dewantiningrum, Noor Pramono
Formato:	article
Lenguaje:	EN
Publicado:	Diponegoro University 2020
Materias:	ocp tranexamic acid aub Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ac282d3a83fb48ff9ebf614b3bc746d7
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spelling	oai:doaj.org-article:ac282d3a83fb48ff9ebf614b3bc746d72021-11-05T16:47:32ZRandomized Controlled Trial of Tranexamic Acid’s Effect on Bleeding Length: A Study on DMPA Users with Abnormal Uterine Bleeding Who Receive Low-Dose Oral Contraceptive Pill2503-217810.14710/jbtr.v6i1.4450https://doaj.org/article/ac282d3a83fb48ff9ebf614b3bc746d72020-04-01T00:00:00Zhttps://ejournal2.undip.ac.id/index.php/jbtr/article/view/4450https://doaj.org/toc/2503-2178ABSTRACT Background: Contraceptive injection is the most common contraception used in Indonesia. Among the contraceptive injections, depomedroxy progesterone acetate (DMPA) is the most effective method with pregnancy rate of 0,3 pregnancy in 100 women annually. Abnormal uterine bleeding (AUB) is a common side effect occurred in DMPA users which leads to the discontinuation of contraception. Objective: To explore the effect of tranexamic acid on bleeding length for DMPA users with AUB who receive low dose Oral Contraceptive Pills (OCP). Methods: We performed double blind randomized control trial between two groups to investigate the effect of tranexamic in managing AUB in DMPA users who receive low dose OCP. This study was performed in Dr. Kariadi Hospital Semarang, Indonesia. Forty-four subjects were divided into two groups, equally. Group 1 received 250 mg tranexamic acid four times a day for 5 days and OCP once a day for 28 days, while Group 2 received placebo four times a day for 5 days and OCP once a day for 28 days. Both groups were evaluated for bleeding length during treatment and were analyzed using Mann Whitney for post treatment with tranexamic acid. Results: The mean bleeding length was 5.2±3.62 days and 9.2±6.16 days in group 1 and 2 respectively. These bleeding lengths were significantly different between both groups (p=0.018). The precentage of subjects in whom bleeding was stopped during the first week after initial treatment was significantly higher in group 1 than group 2 (77,3 % vs 45,5 %, p<0,030). Conclusion: Tranexamic acid significantly reduced the bleeding length in DMPA users who use OCP.Rabiah AdawiyahInu MulyantoroJulian DewantiningrumNoor PramonoDiponegoro Universityarticleocptranexamic acidaubMedicine (General)R5-920ENJournal of Biomedicine and Translational Research, Vol 6, Iss 1, Pp 1-5 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	ocp tranexamic acid aub Medicine (General) R5-920
spellingShingle	ocp tranexamic acid aub Medicine (General) R5-920 Rabiah Adawiyah Inu Mulyantoro Julian Dewantiningrum Noor Pramono Randomized Controlled Trial of Tranexamic Acid’s Effect on Bleeding Length: A Study on DMPA Users with Abnormal Uterine Bleeding Who Receive Low-Dose Oral Contraceptive Pill
description	ABSTRACT Background: Contraceptive injection is the most common contraception used in Indonesia. Among the contraceptive injections, depomedroxy progesterone acetate (DMPA) is the most effective method with pregnancy rate of 0,3 pregnancy in 100 women annually. Abnormal uterine bleeding (AUB) is a common side effect occurred in DMPA users which leads to the discontinuation of contraception. Objective: To explore the effect of tranexamic acid on bleeding length for DMPA users with AUB who receive low dose Oral Contraceptive Pills (OCP). Methods: We performed double blind randomized control trial between two groups to investigate the effect of tranexamic in managing AUB in DMPA users who receive low dose OCP. This study was performed in Dr. Kariadi Hospital Semarang, Indonesia. Forty-four subjects were divided into two groups, equally. Group 1 received 250 mg tranexamic acid four times a day for 5 days and OCP once a day for 28 days, while Group 2 received placebo four times a day for 5 days and OCP once a day for 28 days. Both groups were evaluated for bleeding length during treatment and were analyzed using Mann Whitney for post treatment with tranexamic acid. Results: The mean bleeding length was 5.2±3.62 days and 9.2±6.16 days in group 1 and 2 respectively. These bleeding lengths were significantly different between both groups (p=0.018). The precentage of subjects in whom bleeding was stopped during the first week after initial treatment was significantly higher in group 1 than group 2 (77,3 % vs 45,5 %, p<0,030). Conclusion: Tranexamic acid significantly reduced the bleeding length in DMPA users who use OCP.
format	article
author	Rabiah Adawiyah Inu Mulyantoro Julian Dewantiningrum Noor Pramono
author_facet	Rabiah Adawiyah Inu Mulyantoro Julian Dewantiningrum Noor Pramono
author_sort	Rabiah Adawiyah
title	Randomized Controlled Trial of Tranexamic Acid’s Effect on Bleeding Length: A Study on DMPA Users with Abnormal Uterine Bleeding Who Receive Low-Dose Oral Contraceptive Pill
title_short	Randomized Controlled Trial of Tranexamic Acid’s Effect on Bleeding Length: A Study on DMPA Users with Abnormal Uterine Bleeding Who Receive Low-Dose Oral Contraceptive Pill
title_full	Randomized Controlled Trial of Tranexamic Acid’s Effect on Bleeding Length: A Study on DMPA Users with Abnormal Uterine Bleeding Who Receive Low-Dose Oral Contraceptive Pill
title_fullStr	Randomized Controlled Trial of Tranexamic Acid’s Effect on Bleeding Length: A Study on DMPA Users with Abnormal Uterine Bleeding Who Receive Low-Dose Oral Contraceptive Pill
title_full_unstemmed	Randomized Controlled Trial of Tranexamic Acid’s Effect on Bleeding Length: A Study on DMPA Users with Abnormal Uterine Bleeding Who Receive Low-Dose Oral Contraceptive Pill
title_sort	randomized controlled trial of tranexamic acid’s effect on bleeding length: a study on dmpa users with abnormal uterine bleeding who receive low-dose oral contraceptive pill
publisher	Diponegoro University
publishDate	2020
url	https://doaj.org/article/ac282d3a83fb48ff9ebf614b3bc746d7
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Randomized Controlled Trial of Tranexamic Acid’s Effect on Bleeding Length: A Study on DMPA Users with Abnormal Uterine Bleeding Who Receive Low-Dose Oral Contraceptive Pill

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