THE COMPLETE CLINICAL RESPONSE IN RECTAL CARCINOMA AFTER CHEMO RADIATION

Objective: To determine the complete clinical response in rectal carcinoma after neoadjuvant chemo radiation. Study Design: Cross-sectional study. Place and Duration of Study: This study was conducted in Clinical Oncology department, Jinnah Postgraduate Medical Centre Karachi, from Jan 2016 to Ja...

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Autores principales:	Ammara Manzoor, Ghulam Haider, Saima Zahoor, Ravisha Bai, Muhammad Ejaz Khan, Maqbool Ahmad
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2018
Materias:	advanced adenocarcinoma rectal cancer chemo-radiation complete clinical response (ccr) neoadjuvant chemoradiotherapy Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ac28e0a0575c43948e25add19213332d
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spelling	oai:doaj.org-article:ac28e0a0575c43948e25add19213332d2021-12-02T03:05:49ZTHE COMPLETE CLINICAL RESPONSE IN RECTAL CARCINOMA AFTER CHEMO RADIATION0030-96482411-8842https://doaj.org/article/ac28e0a0575c43948e25add19213332d2018-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2287/1983https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the complete clinical response in rectal carcinoma after neoadjuvant chemo radiation. Study Design: Cross-sectional study. Place and Duration of Study: This study was conducted in Clinical Oncology department, Jinnah Postgraduate Medical Centre Karachi, from Jan 2016 to Jan 2017. Material and Methods: Seventy Two Patients meeting the inclusion criteria were enrolled in study after complete staging workup. Neoadjuvant concurrent chemoradiotherapy was planned, consisting of oral capecitabine 825mg/m2 BID five days a week along with 50.4 Gy Radiotherapy with linac machine. Radiation was delivered over a period of 5 weeks at a rate of 1.8 Gy/day. Patients received Radiotherapy in Atomic Energy Medical Centre (AEMC) and in Sindh Institute Urology & Transplant (SIUT), Radiation department. Chemotherapy was given in clinical oncology department of JPMC. Sixty one patients completed planned treatment and were available for post concomitant chemo radiotherapy response assessment with Pelvic CT/MRI after 6-8 weeks of completion of concomitant chemo radiotherapy. Response assessment was done according to Response Evaluation Criteria in solid tumor (RECIST) criteria version 1.1 and then Patients were referred for surgical evaluation. Result: A total of 61 cases of locally advanced adenocarcinoma rectal cancer patients were included in the study. Mean age of the patients was 41 years with ± 17.06 years SD. Complete clinical response was identified in 4 (6.6%) while 31 (50.8%) were identified as partial response, progressive disease was 13 (21.3%) and 13 (21.3%) were with stable disease. All confounding variables were found statistically significant with p-value found less than 0.05. Conclusion: Neo-adjuvant chemoradiotherapy for locally advanced rectal cancer is associated with high rates of tumor response in terms of downs tagging (complete & partial) and is relatively safe with acceptable morbidity, which favors its use in future.Ammara ManzoorGhulam HaiderSaima ZahoorRavisha BaiMuhammad Ejaz KhanMaqbool AhmadArmy Medical College Rawalpindiarticleadvanced adenocarcinoma rectal cancerchemo-radiationcomplete clinical response (ccr)neoadjuvantchemoradiotherapyMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 68, Iss 5, Pp 1179-1185 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	advanced adenocarcinoma rectal cancer chemo-radiation complete clinical response (ccr) neoadjuvant chemoradiotherapy Medicine R Medicine (General) R5-920
spellingShingle	advanced adenocarcinoma rectal cancer chemo-radiation complete clinical response (ccr) neoadjuvant chemoradiotherapy Medicine R Medicine (General) R5-920 Ammara Manzoor Ghulam Haider Saima Zahoor Ravisha Bai Muhammad Ejaz Khan Maqbool Ahmad THE COMPLETE CLINICAL RESPONSE IN RECTAL CARCINOMA AFTER CHEMO RADIATION
description	Objective: To determine the complete clinical response in rectal carcinoma after neoadjuvant chemo radiation. Study Design: Cross-sectional study. Place and Duration of Study: This study was conducted in Clinical Oncology department, Jinnah Postgraduate Medical Centre Karachi, from Jan 2016 to Jan 2017. Material and Methods: Seventy Two Patients meeting the inclusion criteria were enrolled in study after complete staging workup. Neoadjuvant concurrent chemoradiotherapy was planned, consisting of oral capecitabine 825mg/m2 BID five days a week along with 50.4 Gy Radiotherapy with linac machine. Radiation was delivered over a period of 5 weeks at a rate of 1.8 Gy/day. Patients received Radiotherapy in Atomic Energy Medical Centre (AEMC) and in Sindh Institute Urology & Transplant (SIUT), Radiation department. Chemotherapy was given in clinical oncology department of JPMC. Sixty one patients completed planned treatment and were available for post concomitant chemo radiotherapy response assessment with Pelvic CT/MRI after 6-8 weeks of completion of concomitant chemo radiotherapy. Response assessment was done according to Response Evaluation Criteria in solid tumor (RECIST) criteria version 1.1 and then Patients were referred for surgical evaluation. Result: A total of 61 cases of locally advanced adenocarcinoma rectal cancer patients were included in the study. Mean age of the patients was 41 years with ± 17.06 years SD. Complete clinical response was identified in 4 (6.6%) while 31 (50.8%) were identified as partial response, progressive disease was 13 (21.3%) and 13 (21.3%) were with stable disease. All confounding variables were found statistically significant with p-value found less than 0.05. Conclusion: Neo-adjuvant chemoradiotherapy for locally advanced rectal cancer is associated with high rates of tumor response in terms of downs tagging (complete & partial) and is relatively safe with acceptable morbidity, which favors its use in future.
format	article
author	Ammara Manzoor Ghulam Haider Saima Zahoor Ravisha Bai Muhammad Ejaz Khan Maqbool Ahmad
author_facet	Ammara Manzoor Ghulam Haider Saima Zahoor Ravisha Bai Muhammad Ejaz Khan Maqbool Ahmad
author_sort	Ammara Manzoor
title	THE COMPLETE CLINICAL RESPONSE IN RECTAL CARCINOMA AFTER CHEMO RADIATION
title_short	THE COMPLETE CLINICAL RESPONSE IN RECTAL CARCINOMA AFTER CHEMO RADIATION
title_full	THE COMPLETE CLINICAL RESPONSE IN RECTAL CARCINOMA AFTER CHEMO RADIATION
title_fullStr	THE COMPLETE CLINICAL RESPONSE IN RECTAL CARCINOMA AFTER CHEMO RADIATION
title_full_unstemmed	THE COMPLETE CLINICAL RESPONSE IN RECTAL CARCINOMA AFTER CHEMO RADIATION
title_sort	complete clinical response in rectal carcinoma after chemo radiation
publisher	Army Medical College Rawalpindi
publishDate	2018
url	https://doaj.org/article/ac28e0a0575c43948e25add19213332d
work_keys_str_mv	AT ammaramanzoor thecompleteclinicalresponseinrectalcarcinomaafterchemoradiation AT ghulamhaider thecompleteclinicalresponseinrectalcarcinomaafterchemoradiation AT saimazahoor thecompleteclinicalresponseinrectalcarcinomaafterchemoradiation AT ravishabai thecompleteclinicalresponseinrectalcarcinomaafterchemoradiation AT muhammadejazkhan thecompleteclinicalresponseinrectalcarcinomaafterchemoradiation AT maqboolahmad thecompleteclinicalresponseinrectalcarcinomaafterchemoradiation AT ammaramanzoor completeclinicalresponseinrectalcarcinomaafterchemoradiation AT ghulamhaider completeclinicalresponseinrectalcarcinomaafterchemoradiation AT saimazahoor completeclinicalresponseinrectalcarcinomaafterchemoradiation AT ravishabai completeclinicalresponseinrectalcarcinomaafterchemoradiation AT muhammadejazkhan completeclinicalresponseinrectalcarcinomaafterchemoradiation AT maqboolahmad completeclinicalresponseinrectalcarcinomaafterchemoradiation
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THE COMPLETE CLINICAL RESPONSE IN RECTAL CARCINOMA AFTER CHEMO RADIATION

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