An Overview of Clinical and Pathological Characteristics and Survival Rate of Colorectal Cancer in Iran

Context: Colorectal cancer is one of the most common cancers and the leading cause of cancer death in Iran. This study aimed to identify the clinical and pathological characteristics, as well as survival rate of colorectal cancer in Iran.Evidence Acquisition: The articles published in PubMed without...

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Autores principales:	Sareh Hoseini, Leila Moaddabshoar, Simin Hemati, Mohammad Mohammadianpanah
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2014
Materias:	colorectal neoplasms clinical characteristics pathology survival Medicine R
Acceso en línea:	https://doaj.org/article/ac29f60474c245f6b7dfbdc98e336f96
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spelling	oai:doaj.org-article:ac29f60474c245f6b7dfbdc98e336f962021-11-14T07:57:09ZAn Overview of Clinical and Pathological Characteristics and Survival Rate of Colorectal Cancer in Iran2783-2430https://doaj.org/article/ac29f60474c245f6b7dfbdc98e336f962014-03-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_45854_35f9ebe26c7c8b0aef7909e16e6edf1c.pdfhttps://doaj.org/toc/2783-2430Context: Colorectal cancer is one of the most common cancers and the leading cause of cancer death in Iran. This study aimed to identify the clinical and pathological characteristics, as well as survival rate of colorectal cancer in Iran.Evidence Acquisition: The articles published in PubMed without language and time restrictions were included in this review. Only original clinical articles were included in the review and non-clinical studies, including cellular, molecular, genetics, and animal reports, were excluded. The case reports, letters, reviews, and clinical reports with less than 100 patients were excluded, as well. All the clinical data regarding the patients’ demographics, tumor characteristics, and survival rate were collected.Results: A total of 178 studies were identified at the initial step of literature search. After applying the inclusion and exclusion criteria, 27 studies, including 37901 patients were eligible. The mean age of the patients was 57.2 years, and the male-female ratio was 1.38. Colon, rectum, and rectosigmoid junction accounted for 58%, 28%, and 14% of all colorectal primary sites, respectively. Moreover, the average proportion of the patients with stages 0-I, II, III, and IV was 9%, 39%, 36%, and 16%, respectively. Besides, tumor grades 1, 2, and 3 were reported in 52%, 37%, and 11% of the patients, respectively. Adenocarcinoma (96.8%) was the most frequent histological type. The mean and median survival rate was 80.1 and 55.2 months, respectively. Additionally, the average 5-year overall survival rate was 52.5%.Conclusions: In Iran, colorectal cancer tends to manifest at locally advanced stage with poor prognosis. Therefore, public health strategies, such as screening programs, should be planned for early detection of this aggressive neoplasm.Sareh HoseiniLeila MoaddabshoarSimin HematiMohammad MohammadianpanahShiraz University of Medical Sciencesarticlecolorectal neoplasmsclinical characteristicspathologysurvivalMedicineRENIranian Journal of Colorectal Research, Vol 2, Iss 1, Pp 1-8 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal neoplasms clinical characteristics pathology survival Medicine R
spellingShingle	colorectal neoplasms clinical characteristics pathology survival Medicine R Sareh Hoseini Leila Moaddabshoar Simin Hemati Mohammad Mohammadianpanah An Overview of Clinical and Pathological Characteristics and Survival Rate of Colorectal Cancer in Iran
description	Context: Colorectal cancer is one of the most common cancers and the leading cause of cancer death in Iran. This study aimed to identify the clinical and pathological characteristics, as well as survival rate of colorectal cancer in Iran.Evidence Acquisition: The articles published in PubMed without language and time restrictions were included in this review. Only original clinical articles were included in the review and non-clinical studies, including cellular, molecular, genetics, and animal reports, were excluded. The case reports, letters, reviews, and clinical reports with less than 100 patients were excluded, as well. All the clinical data regarding the patients’ demographics, tumor characteristics, and survival rate were collected.Results: A total of 178 studies were identified at the initial step of literature search. After applying the inclusion and exclusion criteria, 27 studies, including 37901 patients were eligible. The mean age of the patients was 57.2 years, and the male-female ratio was 1.38. Colon, rectum, and rectosigmoid junction accounted for 58%, 28%, and 14% of all colorectal primary sites, respectively. Moreover, the average proportion of the patients with stages 0-I, II, III, and IV was 9%, 39%, 36%, and 16%, respectively. Besides, tumor grades 1, 2, and 3 were reported in 52%, 37%, and 11% of the patients, respectively. Adenocarcinoma (96.8%) was the most frequent histological type. The mean and median survival rate was 80.1 and 55.2 months, respectively. Additionally, the average 5-year overall survival rate was 52.5%.Conclusions: In Iran, colorectal cancer tends to manifest at locally advanced stage with poor prognosis. Therefore, public health strategies, such as screening programs, should be planned for early detection of this aggressive neoplasm.
format	article
author	Sareh Hoseini Leila Moaddabshoar Simin Hemati Mohammad Mohammadianpanah
author_facet	Sareh Hoseini Leila Moaddabshoar Simin Hemati Mohammad Mohammadianpanah
author_sort	Sareh Hoseini
title	An Overview of Clinical and Pathological Characteristics and Survival Rate of Colorectal Cancer in Iran
title_short	An Overview of Clinical and Pathological Characteristics and Survival Rate of Colorectal Cancer in Iran
title_full	An Overview of Clinical and Pathological Characteristics and Survival Rate of Colorectal Cancer in Iran
title_fullStr	An Overview of Clinical and Pathological Characteristics and Survival Rate of Colorectal Cancer in Iran
title_full_unstemmed	An Overview of Clinical and Pathological Characteristics and Survival Rate of Colorectal Cancer in Iran
title_sort	overview of clinical and pathological characteristics and survival rate of colorectal cancer in iran
publisher	Shiraz University of Medical Sciences
publishDate	2014
url	https://doaj.org/article/ac29f60474c245f6b7dfbdc98e336f96
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An Overview of Clinical and Pathological Characteristics and Survival Rate of Colorectal Cancer in Iran

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