The pharmacological management of erectile dysfunction – Update 2016
Erectile dysfunction (ED) is a trivial condition with a prevailing incidence worldwide. Phosphodiesterase-5 inhibitors (PDE-5) have revolutionised the treatment of ED and are regarded as one of the most successful drug groups in modern medicine. Generally PDE-5 inhibitors are well tolerated and the...
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oai:doaj.org-article:ac2c0879c48f4050a954caea45b7c80c2021-11-24T07:44:18ZThe pharmacological management of erectile dysfunction – Update 20162078-61902078-620410.4102/safp.v58i4.4521https://doaj.org/article/ac2c0879c48f4050a954caea45b7c80c2016-08-01T00:00:00Zhttps://safpj.co.za/index.php/safpj/article/view/4521https://doaj.org/toc/2078-6190https://doaj.org/toc/2078-6204Erectile dysfunction (ED) is a trivial condition with a prevailing incidence worldwide. Phosphodiesterase-5 inhibitors (PDE-5) have revolutionised the treatment of ED and are regarded as one of the most successful drug groups in modern medicine. Generally PDE-5 inhibitors are well tolerated and the incidence of side-effects is low, however a small percentage of individuals experience headache, flushing and abdominal discomfort, resulting in discontinuation of therapy. This has led to the development of second generation PDE-5 inhibitors, displaying more selectivity for the PDE-5 enzyme thereby reducing treatment interruption and improving compliance. Several other treatment modalities, including testosterone replacement therapy and prostaglandin administration are available for resistant or failed first-line treatment. This review provides an update on the current, and future, available drugs used in the management of ED.André MaraisAOSISarticlecardiovascular diseaseerectile dysfunctionphosphodiesterase-5 inhibitorsprostaglandintestosteroneMedicineRENSouth African Family Practice, Vol 58, Iss 4, Pp 10-14 (2016) |
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cardiovascular disease erectile dysfunction phosphodiesterase-5 inhibitors prostaglandin testosterone Medicine R |
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cardiovascular disease erectile dysfunction phosphodiesterase-5 inhibitors prostaglandin testosterone Medicine R André Marais The pharmacological management of erectile dysfunction – Update 2016 |
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Erectile dysfunction (ED) is a trivial condition with a prevailing incidence worldwide. Phosphodiesterase-5 inhibitors (PDE-5) have revolutionised the treatment of ED and are regarded as one of the most successful drug groups in modern medicine. Generally PDE-5 inhibitors are well tolerated and the incidence of side-effects is low, however a small percentage of individuals experience headache, flushing and abdominal discomfort, resulting in discontinuation of therapy. This has led to the development of second generation PDE-5 inhibitors, displaying more selectivity for the PDE-5 enzyme thereby reducing treatment interruption and improving compliance. Several other treatment modalities, including testosterone replacement therapy and prostaglandin administration are available for resistant or failed first-line treatment. This review provides an update on the current, and future, available drugs used in the management of ED. |
format |
article |
author |
André Marais |
author_facet |
André Marais |
author_sort |
André Marais |
title |
The pharmacological management of erectile dysfunction – Update 2016 |
title_short |
The pharmacological management of erectile dysfunction – Update 2016 |
title_full |
The pharmacological management of erectile dysfunction – Update 2016 |
title_fullStr |
The pharmacological management of erectile dysfunction – Update 2016 |
title_full_unstemmed |
The pharmacological management of erectile dysfunction – Update 2016 |
title_sort |
pharmacological management of erectile dysfunction – update 2016 |
publisher |
AOSIS |
publishDate |
2016 |
url |
https://doaj.org/article/ac2c0879c48f4050a954caea45b7c80c |
work_keys_str_mv |
AT andremarais thepharmacologicalmanagementoferectiledysfunctionupdate2016 AT andremarais pharmacologicalmanagementoferectiledysfunctionupdate2016 |
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