Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization

Abstract Cerebral malaria is a life-threatening complication of Plasmodia infection and a major cause of child mortality in Sub-Saharan Africa. We report that protection from experimental cerebral malaria in the rodent model is obtained by a single intravenous or subcutaneous whole-parasite immuniza...

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Autores principales:	Kirsten Heiss, Marion Irmgard Maier, Angelika Hoffmann, Roland Frank, Martin Bendszus, Ann-Kristin Mueller, Johannes Pfeil
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ac2e1e92adb242c4a3afb6b1c60d8f6b
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spelling	oai:doaj.org-article:ac2e1e92adb242c4a3afb6b1c60d8f6b2021-12-02T15:08:03ZProtection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization10.1038/s41598-018-21551-22045-2322https://doaj.org/article/ac2e1e92adb242c4a3afb6b1c60d8f6b2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-21551-2https://doaj.org/toc/2045-2322Abstract Cerebral malaria is a life-threatening complication of Plasmodia infection and a major cause of child mortality in Sub-Saharan Africa. We report that protection from experimental cerebral malaria in the rodent model is obtained by a single intravenous or subcutaneous whole-parasite immunization. Whole-parasite immunization with radiation-attenuated sporozoites was equally protective as immunization with non-attenuated sporozoites under chemoprophylaxis. Both immunization regimens delayed the development of blood-stage parasites, but differences in cellular and humoral immune mechanisms were observed. Single-dose whole-parasite vaccination might serve as a relatively simple and feasible immunization approach to prevent life-threatening cerebral malaria.Kirsten HeissMarion Irmgard MaierAngelika HoffmannRoland FrankMartin BendszusAnn-Kristin MuellerJohannes PfeilNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kirsten Heiss Marion Irmgard Maier Angelika Hoffmann Roland Frank Martin Bendszus Ann-Kristin Mueller Johannes Pfeil Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization
description	Abstract Cerebral malaria is a life-threatening complication of Plasmodia infection and a major cause of child mortality in Sub-Saharan Africa. We report that protection from experimental cerebral malaria in the rodent model is obtained by a single intravenous or subcutaneous whole-parasite immunization. Whole-parasite immunization with radiation-attenuated sporozoites was equally protective as immunization with non-attenuated sporozoites under chemoprophylaxis. Both immunization regimens delayed the development of blood-stage parasites, but differences in cellular and humoral immune mechanisms were observed. Single-dose whole-parasite vaccination might serve as a relatively simple and feasible immunization approach to prevent life-threatening cerebral malaria.
format	article
author	Kirsten Heiss Marion Irmgard Maier Angelika Hoffmann Roland Frank Martin Bendszus Ann-Kristin Mueller Johannes Pfeil
author_facet	Kirsten Heiss Marion Irmgard Maier Angelika Hoffmann Roland Frank Martin Bendszus Ann-Kristin Mueller Johannes Pfeil
author_sort	Kirsten Heiss
title	Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization
title_short	Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization
title_full	Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization
title_fullStr	Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization
title_full_unstemmed	Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization
title_sort	protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ac2e1e92adb242c4a3afb6b1c60d8f6b
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Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization

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