Amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments

Abstract During tissue invasion individual tumor cells exhibit two interconvertible migration modes, namely mesenchymal and amoeboid migration. The cellular microenvironment triggers the switch between both modes, thereby allowing adaptation to dynamic conditions. It is, however, unclear if this amo...

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Autores principales: Katrin Talkenberger, Elisabetta Ada Cavalcanti-Adam, Anja Voss-Böhme, Andreas Deutsch
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/ac30830f1fea4192b35fc976d9691ea0
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spelling oai:doaj.org-article:ac30830f1fea4192b35fc976d9691ea02021-12-02T11:52:35ZAmoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments10.1038/s41598-017-09300-32045-2322https://doaj.org/article/ac30830f1fea4192b35fc976d9691ea02017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09300-3https://doaj.org/toc/2045-2322Abstract During tissue invasion individual tumor cells exhibit two interconvertible migration modes, namely mesenchymal and amoeboid migration. The cellular microenvironment triggers the switch between both modes, thereby allowing adaptation to dynamic conditions. It is, however, unclear if this amoeboid-mesenchymal migration plasticity contributes to a more effective tumor invasion. We address this question with a mathematical model, where the amoeboid-mesenchymal migration plasticity is regulated in response to local extracellular matrix resistance. Our numerical analysis reveals that extracellular matrix structure and presence of a chemotactic gradient are key determinants of the model behavior. Only in complex microenvironments, if the extracellular matrix is highly heterogeneous and a chemotactic gradient directs migration, the amoeboid-mesenchymal migration plasticity allows a more widespread invasion compared to the non-switching amoeboid and mesenchymal modes. Importantly, these specific conditions are characteristic for in vivo tumor invasion. Thus, our study suggests that in vitro systems aiming at unraveling the underlying molecular mechanisms of tumor invasion should take into account the complexity of the microenvironment by considering the combined effects of structural heterogeneities and chemical gradients on cell migration.Katrin TalkenbergerElisabetta Ada Cavalcanti-AdamAnja Voss-BöhmeAndreas DeutschNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Katrin Talkenberger
Elisabetta Ada Cavalcanti-Adam
Anja Voss-Böhme
Andreas Deutsch
Amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments
description Abstract During tissue invasion individual tumor cells exhibit two interconvertible migration modes, namely mesenchymal and amoeboid migration. The cellular microenvironment triggers the switch between both modes, thereby allowing adaptation to dynamic conditions. It is, however, unclear if this amoeboid-mesenchymal migration plasticity contributes to a more effective tumor invasion. We address this question with a mathematical model, where the amoeboid-mesenchymal migration plasticity is regulated in response to local extracellular matrix resistance. Our numerical analysis reveals that extracellular matrix structure and presence of a chemotactic gradient are key determinants of the model behavior. Only in complex microenvironments, if the extracellular matrix is highly heterogeneous and a chemotactic gradient directs migration, the amoeboid-mesenchymal migration plasticity allows a more widespread invasion compared to the non-switching amoeboid and mesenchymal modes. Importantly, these specific conditions are characteristic for in vivo tumor invasion. Thus, our study suggests that in vitro systems aiming at unraveling the underlying molecular mechanisms of tumor invasion should take into account the complexity of the microenvironment by considering the combined effects of structural heterogeneities and chemical gradients on cell migration.
format article
author Katrin Talkenberger
Elisabetta Ada Cavalcanti-Adam
Anja Voss-Böhme
Andreas Deutsch
author_facet Katrin Talkenberger
Elisabetta Ada Cavalcanti-Adam
Anja Voss-Böhme
Andreas Deutsch
author_sort Katrin Talkenberger
title Amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments
title_short Amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments
title_full Amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments
title_fullStr Amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments
title_full_unstemmed Amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments
title_sort amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/ac30830f1fea4192b35fc976d9691ea0
work_keys_str_mv AT katrintalkenberger amoeboidmesenchymalmigrationplasticitypromotesinvasiononlyincomplexheterogeneousmicroenvironments
AT elisabettaadacavalcantiadam amoeboidmesenchymalmigrationplasticitypromotesinvasiononlyincomplexheterogeneousmicroenvironments
AT anjavossbohme amoeboidmesenchymalmigrationplasticitypromotesinvasiononlyincomplexheterogeneousmicroenvironments
AT andreasdeutsch amoeboidmesenchymalmigrationplasticitypromotesinvasiononlyincomplexheterogeneousmicroenvironments
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