Amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments

Abstract During tissue invasion individual tumor cells exhibit two interconvertible migration modes, namely mesenchymal and amoeboid migration. The cellular microenvironment triggers the switch between both modes, thereby allowing adaptation to dynamic conditions. It is, however, unclear if this amo...

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Autores principales:	Katrin Talkenberger, Elisabetta Ada Cavalcanti-Adam, Anja Voss-Böhme, Andreas Deutsch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ac30830f1fea4192b35fc976d9691ea0
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spelling	oai:doaj.org-article:ac30830f1fea4192b35fc976d9691ea02021-12-02T11:52:35ZAmoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments10.1038/s41598-017-09300-32045-2322https://doaj.org/article/ac30830f1fea4192b35fc976d9691ea02017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09300-3https://doaj.org/toc/2045-2322Abstract During tissue invasion individual tumor cells exhibit two interconvertible migration modes, namely mesenchymal and amoeboid migration. The cellular microenvironment triggers the switch between both modes, thereby allowing adaptation to dynamic conditions. It is, however, unclear if this amoeboid-mesenchymal migration plasticity contributes to a more effective tumor invasion. We address this question with a mathematical model, where the amoeboid-mesenchymal migration plasticity is regulated in response to local extracellular matrix resistance. Our numerical analysis reveals that extracellular matrix structure and presence of a chemotactic gradient are key determinants of the model behavior. Only in complex microenvironments, if the extracellular matrix is highly heterogeneous and a chemotactic gradient directs migration, the amoeboid-mesenchymal migration plasticity allows a more widespread invasion compared to the non-switching amoeboid and mesenchymal modes. Importantly, these specific conditions are characteristic for in vivo tumor invasion. Thus, our study suggests that in vitro systems aiming at unraveling the underlying molecular mechanisms of tumor invasion should take into account the complexity of the microenvironment by considering the combined effects of structural heterogeneities and chemical gradients on cell migration.Katrin TalkenbergerElisabetta Ada Cavalcanti-AdamAnja Voss-BöhmeAndreas DeutschNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katrin Talkenberger Elisabetta Ada Cavalcanti-Adam Anja Voss-Böhme Andreas Deutsch Amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments
description	Abstract During tissue invasion individual tumor cells exhibit two interconvertible migration modes, namely mesenchymal and amoeboid migration. The cellular microenvironment triggers the switch between both modes, thereby allowing adaptation to dynamic conditions. It is, however, unclear if this amoeboid-mesenchymal migration plasticity contributes to a more effective tumor invasion. We address this question with a mathematical model, where the amoeboid-mesenchymal migration plasticity is regulated in response to local extracellular matrix resistance. Our numerical analysis reveals that extracellular matrix structure and presence of a chemotactic gradient are key determinants of the model behavior. Only in complex microenvironments, if the extracellular matrix is highly heterogeneous and a chemotactic gradient directs migration, the amoeboid-mesenchymal migration plasticity allows a more widespread invasion compared to the non-switching amoeboid and mesenchymal modes. Importantly, these specific conditions are characteristic for in vivo tumor invasion. Thus, our study suggests that in vitro systems aiming at unraveling the underlying molecular mechanisms of tumor invasion should take into account the complexity of the microenvironment by considering the combined effects of structural heterogeneities and chemical gradients on cell migration.
format	article
author	Katrin Talkenberger Elisabetta Ada Cavalcanti-Adam Anja Voss-Böhme Andreas Deutsch
author_facet	Katrin Talkenberger Elisabetta Ada Cavalcanti-Adam Anja Voss-Böhme Andreas Deutsch
author_sort	Katrin Talkenberger
title	Amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments
title_short	Amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments
title_full	Amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments
title_fullStr	Amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments
title_full_unstemmed	Amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments
title_sort	amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ac30830f1fea4192b35fc976d9691ea0
work_keys_str_mv	AT katrintalkenberger amoeboidmesenchymalmigrationplasticitypromotesinvasiononlyincomplexheterogeneousmicroenvironments AT elisabettaadacavalcantiadam amoeboidmesenchymalmigrationplasticitypromotesinvasiononlyincomplexheterogeneousmicroenvironments AT anjavossbohme amoeboidmesenchymalmigrationplasticitypromotesinvasiononlyincomplexheterogeneousmicroenvironments AT andreasdeutsch amoeboidmesenchymalmigrationplasticitypromotesinvasiononlyincomplexheterogeneousmicroenvironments
_version_	1718395004080095232

Amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments

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