Acute and repeated dose 60-day oral toxicity assessment of chemically characterized Berberis hispanica Boiss. and Reut in Wistar rats
Berberis hispanica Boiss. & Reut (B. hispanica) belongs to the family Berberidaceae, which is currently used in traditional medicines. This article aimed to study the phytochemical composition and acute and subacute toxicity of B. hispanica extract in rats. The phytochemical composition of B. hi...
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De Gruyter
2021
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oai:doaj.org-article:ac32350a81cb41d68d1836315ebaa1ff2021-12-05T14:10:44ZAcute and repeated dose 60-day oral toxicity assessment of chemically characterized Berberis hispanica Boiss. and Reut in Wistar rats2391-542010.1515/chem-2021-0057https://doaj.org/article/ac32350a81cb41d68d1836315ebaa1ff2021-06-01T00:00:00Zhttps://doi.org/10.1515/chem-2021-0057https://doaj.org/toc/2391-5420Berberis hispanica Boiss. & Reut (B. hispanica) belongs to the family Berberidaceae, which is currently used in traditional medicines. This article aimed to study the phytochemical composition and acute and subacute toxicity of B. hispanica extract in rats. The phytochemical composition of B. hispanica extract was characterized using GC-MS. The acute toxicity was investigated in vivo via the oral administration of single doses including 400, 800, 1,000, 1,200, and 1,400 mg/kg for 14 days. The subchronic toxicity was studied through oral administration of 400 mg/kg for 60 days. The findings of the phytochemical analysis of B. hispanica extract showed the presence of various phytochemical compounds. Acute toxicity results revealed serious clinical symptoms and mortalities in rats treated with 800 mg/kg up to a maximum of 1,400 mg/kg. With acute toxicity, subchronic toxicity results showed also serious signs of toxicity including biochemical and histological alterations in animals treated with 1,400 mg/kg. B. hispanica extract revealed to be toxic in rats orally treated under both subacute (>400 mg/kg) and subchronic toxicity conditions (400 mg/kg). The outcome of this study serves the society as it provides toxicological evidence of B. hispanica used in alternative medicinesEl Fakir LoubnaBourhia MohammedSalamatullah Ahmad MohammadAlzahrani AbdulhakeemUllah RiazEzzeldin EssamMostafa Gamal A.Bari AhmedAlaoui TajelmolkGmouh SaidBenbacer LailaZaid AbdelhamidDe Gruyterarticletoxicitybiochemical parametershistopathologychemical characterizationChemistryQD1-999ENOpen Chemistry, Vol 19, Iss 1, Pp 686-695 (2021) |
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| collection |
DOAJ |
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| topic |
toxicity biochemical parameters histopathology chemical characterization Chemistry QD1-999 |
| spellingShingle |
toxicity biochemical parameters histopathology chemical characterization Chemistry QD1-999 El Fakir Loubna Bourhia Mohammed Salamatullah Ahmad Mohammad Alzahrani Abdulhakeem Ullah Riaz Ezzeldin Essam Mostafa Gamal A. Bari Ahmed Alaoui Tajelmolk Gmouh Said Benbacer Laila Zaid Abdelhamid Acute and repeated dose 60-day oral toxicity assessment of chemically characterized Berberis hispanica Boiss. and Reut in Wistar rats |
| description |
Berberis hispanica Boiss. & Reut (B. hispanica) belongs to the family Berberidaceae, which is currently used in traditional medicines. This article aimed to study the phytochemical composition and acute and subacute toxicity of B. hispanica extract in rats. The phytochemical composition of B. hispanica extract was characterized using GC-MS. The acute toxicity was investigated in vivo via the oral administration of single doses including 400, 800, 1,000, 1,200, and 1,400 mg/kg for 14 days. The subchronic toxicity was studied through oral administration of 400 mg/kg for 60 days. The findings of the phytochemical analysis of B. hispanica extract showed the presence of various phytochemical compounds. Acute toxicity results revealed serious clinical symptoms and mortalities in rats treated with 800 mg/kg up to a maximum of 1,400 mg/kg. With acute toxicity, subchronic toxicity results showed also serious signs of toxicity including biochemical and histological alterations in animals treated with 1,400 mg/kg. B. hispanica extract revealed to be toxic in rats orally treated under both subacute (>400 mg/kg) and subchronic toxicity conditions (400 mg/kg). The outcome of this study serves the society as it provides toxicological evidence of B. hispanica used in alternative medicines |
| format |
article |
| author |
El Fakir Loubna Bourhia Mohammed Salamatullah Ahmad Mohammad Alzahrani Abdulhakeem Ullah Riaz Ezzeldin Essam Mostafa Gamal A. Bari Ahmed Alaoui Tajelmolk Gmouh Said Benbacer Laila Zaid Abdelhamid |
| author_facet |
El Fakir Loubna Bourhia Mohammed Salamatullah Ahmad Mohammad Alzahrani Abdulhakeem Ullah Riaz Ezzeldin Essam Mostafa Gamal A. Bari Ahmed Alaoui Tajelmolk Gmouh Said Benbacer Laila Zaid Abdelhamid |
| author_sort |
El Fakir Loubna |
| title |
Acute and repeated dose 60-day oral toxicity assessment of chemically characterized Berberis hispanica Boiss. and Reut in Wistar rats |
| title_short |
Acute and repeated dose 60-day oral toxicity assessment of chemically characterized Berberis hispanica Boiss. and Reut in Wistar rats |
| title_full |
Acute and repeated dose 60-day oral toxicity assessment of chemically characterized Berberis hispanica Boiss. and Reut in Wistar rats |
| title_fullStr |
Acute and repeated dose 60-day oral toxicity assessment of chemically characterized Berberis hispanica Boiss. and Reut in Wistar rats |
| title_full_unstemmed |
Acute and repeated dose 60-day oral toxicity assessment of chemically characterized Berberis hispanica Boiss. and Reut in Wistar rats |
| title_sort |
acute and repeated dose 60-day oral toxicity assessment of chemically characterized berberis hispanica boiss. and reut in wistar rats |
| publisher |
De Gruyter |
| publishDate |
2021 |
| url |
https://doaj.org/article/ac32350a81cb41d68d1836315ebaa1ff |
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