Characterization of aging-associated cardiac diastolic dysfunction.

<h4>Aims</h4>Diastolic dysfunction is common in geriatric heart failure. A reliable parameter to predict myocardium stiffness and relaxation under similar end-diastolic pressure is being developed. We propose a material and mathematical model for calculating myocardium stiffness based on...

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Autores principales:	Wei-Ting Chang, Jung-San Chen, Yung-Kung Hung, Wei-Chuan Tsai, Jer-Nan Juang, Ping-Yen Liu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ac324ef80cba4fe8832d1585c0a815ed
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spelling	oai:doaj.org-article:ac324ef80cba4fe8832d1585c0a815ed2021-11-18T08:18:00ZCharacterization of aging-associated cardiac diastolic dysfunction.1932-620310.1371/journal.pone.0097455https://doaj.org/article/ac324ef80cba4fe8832d1585c0a815ed2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24869961/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Aims</h4>Diastolic dysfunction is common in geriatric heart failure. A reliable parameter to predict myocardium stiffness and relaxation under similar end-diastolic pressure is being developed. We propose a material and mathematical model for calculating myocardium stiffness based on the concept of linear correlation between [Formula: see text] and wedge pressure.<h4>Methods and results</h4>We enrolled 919 patients (male: [Formula: see text][Formula: see text]). Compared with the younger population of controls (mean age: [Formula: see text] years; [Formula: see text]; male: [Formula: see text] [Formula: see text]), the elderly (mean age: [Formula: see text]; [Formula: see text]; male: [Formula: see text] [Formula: see text]) had a greater prevalence of hypertension, diabetes mellitus, and coronary artery disease (all [Formula: see text]). We collected their M-mode and 2-D echocardiographic volumetric parameters, intraventricular filling pressure, and speckle tracking images to establish a mathematical model. The feasibility of this model was validated. The average early diastolic velocity of the mitral annulus assessed using tissue Doppler imaging was significantly attenuated in the elderly ([Formula: see text]: [Formula: see text] vs. [Formula: see text]; [Formula: see text]) and corresponded to the higher estimated wedge ([Formula: see text]) pressure ([Formula: see text] vs. [Formula: see text]; [Formula: see text]) in that cohort. E (Young's modulus) was calculated to describe the tensile elasticity of the myocardium. With the same intraventricular filling pressure, E was significantly higher in the elderly, especially those with [Formula: see text] values [Formula: see text]. Compared with diastolic dysfunction parameters, E also presented sentinel characteristics more sensitive for detecting early myocardial relaxation impairment, which indicates stiffer myocardium in aging hearts.<h4>Conclusion</h4>Our material and geometric mathematical model successfully described the stiffer myocardium in aging hearts with higher intraventricular pressure. Additional studies that compare individual differences, especially in health status, are needed to validate its application for detecting diastolic heart failure.Wei-Ting ChangJung-San ChenYung-Kung HungWei-Chuan TsaiJer-Nan JuangPing-Yen LiuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e97455 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wei-Ting Chang Jung-San Chen Yung-Kung Hung Wei-Chuan Tsai Jer-Nan Juang Ping-Yen Liu Characterization of aging-associated cardiac diastolic dysfunction.
description	<h4>Aims</h4>Diastolic dysfunction is common in geriatric heart failure. A reliable parameter to predict myocardium stiffness and relaxation under similar end-diastolic pressure is being developed. We propose a material and mathematical model for calculating myocardium stiffness based on the concept of linear correlation between [Formula: see text] and wedge pressure.<h4>Methods and results</h4>We enrolled 919 patients (male: [Formula: see text][Formula: see text]). Compared with the younger population of controls (mean age: [Formula: see text] years; [Formula: see text]; male: [Formula: see text] [Formula: see text]), the elderly (mean age: [Formula: see text]; [Formula: see text]; male: [Formula: see text] [Formula: see text]) had a greater prevalence of hypertension, diabetes mellitus, and coronary artery disease (all [Formula: see text]). We collected their M-mode and 2-D echocardiographic volumetric parameters, intraventricular filling pressure, and speckle tracking images to establish a mathematical model. The feasibility of this model was validated. The average early diastolic velocity of the mitral annulus assessed using tissue Doppler imaging was significantly attenuated in the elderly ([Formula: see text]: [Formula: see text] vs. [Formula: see text]; [Formula: see text]) and corresponded to the higher estimated wedge ([Formula: see text]) pressure ([Formula: see text] vs. [Formula: see text]; [Formula: see text]) in that cohort. E (Young's modulus) was calculated to describe the tensile elasticity of the myocardium. With the same intraventricular filling pressure, E was significantly higher in the elderly, especially those with [Formula: see text] values [Formula: see text]. Compared with diastolic dysfunction parameters, E also presented sentinel characteristics more sensitive for detecting early myocardial relaxation impairment, which indicates stiffer myocardium in aging hearts.<h4>Conclusion</h4>Our material and geometric mathematical model successfully described the stiffer myocardium in aging hearts with higher intraventricular pressure. Additional studies that compare individual differences, especially in health status, are needed to validate its application for detecting diastolic heart failure.
format	article
author	Wei-Ting Chang Jung-San Chen Yung-Kung Hung Wei-Chuan Tsai Jer-Nan Juang Ping-Yen Liu
author_facet	Wei-Ting Chang Jung-San Chen Yung-Kung Hung Wei-Chuan Tsai Jer-Nan Juang Ping-Yen Liu
author_sort	Wei-Ting Chang
title	Characterization of aging-associated cardiac diastolic dysfunction.
title_short	Characterization of aging-associated cardiac diastolic dysfunction.
title_full	Characterization of aging-associated cardiac diastolic dysfunction.
title_fullStr	Characterization of aging-associated cardiac diastolic dysfunction.
title_full_unstemmed	Characterization of aging-associated cardiac diastolic dysfunction.
title_sort	characterization of aging-associated cardiac diastolic dysfunction.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/ac324ef80cba4fe8832d1585c0a815ed
work_keys_str_mv	AT weitingchang characterizationofagingassociatedcardiacdiastolicdysfunction AT jungsanchen characterizationofagingassociatedcardiacdiastolicdysfunction AT yungkunghung characterizationofagingassociatedcardiacdiastolicdysfunction AT weichuantsai characterizationofagingassociatedcardiacdiastolicdysfunction AT jernanjuang characterizationofagingassociatedcardiacdiastolicdysfunction AT pingyenliu characterizationofagingassociatedcardiacdiastolicdysfunction
_version_	1718421942597320704

Characterization of aging-associated cardiac diastolic dysfunction.

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