NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir
Nucleoside analogs (NNA), such as acyclovir (ACV) and ganciclovir (GCV), are widely used as anti-virals to treat herpes virus infection. Here, Nishii et al. show that diphosphatase NUDT15 hydrolyzes ACV and GCV, therewith reducing NNA activity in vitro and link NUDT15 variation to inter-patient vari...
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Nature Portfolio
2021
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oai:doaj.org-article:ac367d8e92bf4e2bb684ff635f13452f2021-12-02T18:34:21ZNUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir10.1038/s41467-021-24509-72041-1723https://doaj.org/article/ac367d8e92bf4e2bb684ff635f13452f2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24509-7https://doaj.org/toc/2041-1723Nucleoside analogs (NNA), such as acyclovir (ACV) and ganciclovir (GCV), are widely used as anti-virals to treat herpes virus infection. Here, Nishii et al. show that diphosphatase NUDT15 hydrolyzes ACV and GCV, therewith reducing NNA activity in vitro and link NUDT15 variation to inter-patient variability in ACV and GCV therapeutic effects.Rina NishiiTakanori MizunoDaniel RehlingColton SmithBrandi L. ClarkXujie ZhaoScott A. BrownBrandon SmartTakaya MoriyamaYuji YamadaTatsuo IchinoheMakoto OnizukaYoshiko AtsutaLei YangWenjian YangPaul G. ThomasPål StenmarkMotohiro KatoJun J. YangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Rina Nishii Takanori Mizuno Daniel Rehling Colton Smith Brandi L. Clark Xujie Zhao Scott A. Brown Brandon Smart Takaya Moriyama Yuji Yamada Tatsuo Ichinohe Makoto Onizuka Yoshiko Atsuta Lei Yang Wenjian Yang Paul G. Thomas Pål Stenmark Motohiro Kato Jun J. Yang NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir |
| description |
Nucleoside analogs (NNA), such as acyclovir (ACV) and ganciclovir (GCV), are widely used as anti-virals to treat herpes virus infection. Here, Nishii et al. show that diphosphatase NUDT15 hydrolyzes ACV and GCV, therewith reducing NNA activity in vitro and link NUDT15 variation to inter-patient variability in ACV and GCV therapeutic effects. |
| format |
article |
| author |
Rina Nishii Takanori Mizuno Daniel Rehling Colton Smith Brandi L. Clark Xujie Zhao Scott A. Brown Brandon Smart Takaya Moriyama Yuji Yamada Tatsuo Ichinohe Makoto Onizuka Yoshiko Atsuta Lei Yang Wenjian Yang Paul G. Thomas Pål Stenmark Motohiro Kato Jun J. Yang |
| author_facet |
Rina Nishii Takanori Mizuno Daniel Rehling Colton Smith Brandi L. Clark Xujie Zhao Scott A. Brown Brandon Smart Takaya Moriyama Yuji Yamada Tatsuo Ichinohe Makoto Onizuka Yoshiko Atsuta Lei Yang Wenjian Yang Paul G. Thomas Pål Stenmark Motohiro Kato Jun J. Yang |
| author_sort |
Rina Nishii |
| title |
NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir |
| title_short |
NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir |
| title_full |
NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir |
| title_fullStr |
NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir |
| title_full_unstemmed |
NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir |
| title_sort |
nudt15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/ac367d8e92bf4e2bb684ff635f13452f |
| work_keys_str_mv |
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1718377879902879744 |