Exploring the Correlation and Protective Role of Diabetes Mellitus in Aortic Aneurysm Disease

Introduction: Diabetes mellitus is recognised as a significant risk factor for cardiovascular and peripheral vascular disease, as the abnormal metabolic state increases the risk for atherosclerosis, occlusive arterial disease and vascular dysfunction. There have been reports of potential association...

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Autores principales:	Divyatha Arun, Wahaj Munir, Lara Victoria Schmitt, Rohan Vyas, Jeuela Iris Ravindran, Mohamad Bashir, Ian Michael Williams, Bashi Velayudhan, Mohammed Idhrees
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	diabetes mellitus aorta aneurysm dissection hyperglycemia insulin resistance Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/ac3b9ffb2bcc497f8f4bce43151b5373
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spelling	oai:doaj.org-article:ac3b9ffb2bcc497f8f4bce43151b53732021-11-08T07:09:52ZExploring the Correlation and Protective Role of Diabetes Mellitus in Aortic Aneurysm Disease2297-055X10.3389/fcvm.2021.769343https://doaj.org/article/ac3b9ffb2bcc497f8f4bce43151b53732021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.769343/fullhttps://doaj.org/toc/2297-055XIntroduction: Diabetes mellitus is recognised as a significant risk factor for cardiovascular and peripheral vascular disease, as the abnormal metabolic state increases the risk for atherosclerosis, occlusive arterial disease and vascular dysfunction. There have been reports of potential association across the literature that illustrates a link between diabetes mellitus and aortic aneurysm, with the former having a protective role on the development of the latter.Methods: A thorough literature search was performed through electronic databases, to provide a comprehensive review of the study's reporting on the association of diabetes mellitus and aortic aneurysm, discussing the mechanisms that have been reported; furthemore, we reviewed the reports of the impact of oral hypoglycameic agents on aortic aneurysms.Results: Various proposed mechanisms are involved in this protective process including endothelial dysfunction, chronic hyperglycemia and insulin resistance. The evidence suggests a negative association between these disease process, with prevelance of diabetes mellitus resulting in lower rates of aortic aneurysm, via its protective mechanistic action. The increase in advanced glycation end products, increased arterial stiffness and vascular remodelling seen in diabetes, was found to have a profound impact on aneurysm development, its slow progression and lower rupture rate in these individuals. This review has also highlighted the role of oral hypoglycaemic agents having a protective effect against AA disease.Conclusion: A decrease in development, progression and mortality from aortic aneurysms as well as reduced rates of dissection, have been observed in those with diabetes. This review has provided a comprehensive insight on the effect of diabetes and its physiological processes, and elements of its con-committant treatment, having a protective role against these aortic diseases.Divyatha ArunWahaj MunirLara Victoria SchmittRohan VyasJeuela Iris RavindranMohamad BashirIan Michael WilliamsBashi VelayudhanMohammed IdhreesFrontiers Media S.A.articlediabetes mellitusaortaaneurysmdissectionhyperglycemiainsulin resistanceDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus aorta aneurysm dissection hyperglycemia insulin resistance Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	diabetes mellitus aorta aneurysm dissection hyperglycemia insulin resistance Diseases of the circulatory (Cardiovascular) system RC666-701 Divyatha Arun Wahaj Munir Lara Victoria Schmitt Rohan Vyas Jeuela Iris Ravindran Mohamad Bashir Ian Michael Williams Bashi Velayudhan Mohammed Idhrees Exploring the Correlation and Protective Role of Diabetes Mellitus in Aortic Aneurysm Disease
description	Introduction: Diabetes mellitus is recognised as a significant risk factor for cardiovascular and peripheral vascular disease, as the abnormal metabolic state increases the risk for atherosclerosis, occlusive arterial disease and vascular dysfunction. There have been reports of potential association across the literature that illustrates a link between diabetes mellitus and aortic aneurysm, with the former having a protective role on the development of the latter.Methods: A thorough literature search was performed through electronic databases, to provide a comprehensive review of the study's reporting on the association of diabetes mellitus and aortic aneurysm, discussing the mechanisms that have been reported; furthemore, we reviewed the reports of the impact of oral hypoglycameic agents on aortic aneurysms.Results: Various proposed mechanisms are involved in this protective process including endothelial dysfunction, chronic hyperglycemia and insulin resistance. The evidence suggests a negative association between these disease process, with prevelance of diabetes mellitus resulting in lower rates of aortic aneurysm, via its protective mechanistic action. The increase in advanced glycation end products, increased arterial stiffness and vascular remodelling seen in diabetes, was found to have a profound impact on aneurysm development, its slow progression and lower rupture rate in these individuals. This review has also highlighted the role of oral hypoglycaemic agents having a protective effect against AA disease.Conclusion: A decrease in development, progression and mortality from aortic aneurysms as well as reduced rates of dissection, have been observed in those with diabetes. This review has provided a comprehensive insight on the effect of diabetes and its physiological processes, and elements of its con-committant treatment, having a protective role against these aortic diseases.
format	article
author	Divyatha Arun Wahaj Munir Lara Victoria Schmitt Rohan Vyas Jeuela Iris Ravindran Mohamad Bashir Ian Michael Williams Bashi Velayudhan Mohammed Idhrees
author_facet	Divyatha Arun Wahaj Munir Lara Victoria Schmitt Rohan Vyas Jeuela Iris Ravindran Mohamad Bashir Ian Michael Williams Bashi Velayudhan Mohammed Idhrees
author_sort	Divyatha Arun
title	Exploring the Correlation and Protective Role of Diabetes Mellitus in Aortic Aneurysm Disease
title_short	Exploring the Correlation and Protective Role of Diabetes Mellitus in Aortic Aneurysm Disease
title_full	Exploring the Correlation and Protective Role of Diabetes Mellitus in Aortic Aneurysm Disease
title_fullStr	Exploring the Correlation and Protective Role of Diabetes Mellitus in Aortic Aneurysm Disease
title_full_unstemmed	Exploring the Correlation and Protective Role of Diabetes Mellitus in Aortic Aneurysm Disease
title_sort	exploring the correlation and protective role of diabetes mellitus in aortic aneurysm disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ac3b9ffb2bcc497f8f4bce43151b5373
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Exploring the Correlation and Protective Role of Diabetes Mellitus in Aortic Aneurysm Disease

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