Propagating acoustic waves on a culture substrate regulate the directional collective cell migration

Abstract Collective cell migration plays a critical role in physiological and pathological processes such as development, wound healing, and metastasis. Numerous studies have demonstrated how various types of chemical, mechanical, and electrical cues dictate the collective migratory behaviors of cel...

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Autores principales:	Chikahiro Imashiro, Byungjun Kang, Yunam Lee, Youn-Hoo Hwang, Seonghun Im, Dae-Eun Kim, Kenjiro Takemura, Hyungsuk Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Technology T Engineering (General). Civil engineering (General) TA1-2040
Acceso en línea:	https://doaj.org/article/ac3c1e5ab34644d3a1367de4cabae919
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spelling	oai:doaj.org-article:ac3c1e5ab34644d3a1367de4cabae9192021-11-14T12:10:01ZPropagating acoustic waves on a culture substrate regulate the directional collective cell migration10.1038/s41378-021-00304-82055-7434https://doaj.org/article/ac3c1e5ab34644d3a1367de4cabae9192021-11-01T00:00:00Zhttps://doi.org/10.1038/s41378-021-00304-8https://doaj.org/toc/2055-7434Abstract Collective cell migration plays a critical role in physiological and pathological processes such as development, wound healing, and metastasis. Numerous studies have demonstrated how various types of chemical, mechanical, and electrical cues dictate the collective migratory behaviors of cells. Although an acoustic cue can be advantageous because of its noninvasiveness and biocompatibility, cell migration in response to acoustic stimulation remains poorly understood. In this study, we developed a device that is able to apply surface acoustic waves to a cell culture substrate and investigated the effect of propagating acoustic waves on collective cell migration. The migration distance estimated at various wave intensities revealed that unidirectional cell migration was enhanced at a critical wave intensity and that it was suppressed as the intensity was further increased. The increased migration might be attributable to cell orientation alignment along the direction of the propagating wave, as characterized by nucleus shape. Thicker actin bundles indicative of a high traction force were observed in cells subjected to propagating acoustic waves at the critical intensity. Our device and technique can be useful for regulating cellular functions associated with cell migration.Chikahiro ImashiroByungjun KangYunam LeeYoun-Hoo HwangSeonghun ImDae-Eun KimKenjiro TakemuraHyungsuk LeeNature Publishing GrouparticleTechnologyTEngineering (General). Civil engineering (General)TA1-2040ENMicrosystems & Nanoengineering, Vol 7, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Technology T Engineering (General). Civil engineering (General) TA1-2040
spellingShingle	Technology T Engineering (General). Civil engineering (General) TA1-2040 Chikahiro Imashiro Byungjun Kang Yunam Lee Youn-Hoo Hwang Seonghun Im Dae-Eun Kim Kenjiro Takemura Hyungsuk Lee Propagating acoustic waves on a culture substrate regulate the directional collective cell migration
description	Abstract Collective cell migration plays a critical role in physiological and pathological processes such as development, wound healing, and metastasis. Numerous studies have demonstrated how various types of chemical, mechanical, and electrical cues dictate the collective migratory behaviors of cells. Although an acoustic cue can be advantageous because of its noninvasiveness and biocompatibility, cell migration in response to acoustic stimulation remains poorly understood. In this study, we developed a device that is able to apply surface acoustic waves to a cell culture substrate and investigated the effect of propagating acoustic waves on collective cell migration. The migration distance estimated at various wave intensities revealed that unidirectional cell migration was enhanced at a critical wave intensity and that it was suppressed as the intensity was further increased. The increased migration might be attributable to cell orientation alignment along the direction of the propagating wave, as characterized by nucleus shape. Thicker actin bundles indicative of a high traction force were observed in cells subjected to propagating acoustic waves at the critical intensity. Our device and technique can be useful for regulating cellular functions associated with cell migration.
format	article
author	Chikahiro Imashiro Byungjun Kang Yunam Lee Youn-Hoo Hwang Seonghun Im Dae-Eun Kim Kenjiro Takemura Hyungsuk Lee
author_facet	Chikahiro Imashiro Byungjun Kang Yunam Lee Youn-Hoo Hwang Seonghun Im Dae-Eun Kim Kenjiro Takemura Hyungsuk Lee
author_sort	Chikahiro Imashiro
title	Propagating acoustic waves on a culture substrate regulate the directional collective cell migration
title_short	Propagating acoustic waves on a culture substrate regulate the directional collective cell migration
title_full	Propagating acoustic waves on a culture substrate regulate the directional collective cell migration
title_fullStr	Propagating acoustic waves on a culture substrate regulate the directional collective cell migration
title_full_unstemmed	Propagating acoustic waves on a culture substrate regulate the directional collective cell migration
title_sort	propagating acoustic waves on a culture substrate regulate the directional collective cell migration
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/ac3c1e5ab34644d3a1367de4cabae919
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Propagating acoustic waves on a culture substrate regulate the directional collective cell migration

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