Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives

Cancer cells can reprogram their metabolic activities and undergo uncontrolled proliferation by utilizing the power of heat shock proteins (HSPs). HSPs are highly conserved chaperones that facilitate the folding of intracellular proteins under stress. Constitutively, HSPs are expressed at low levels...

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Autores principales:	Batoul Abi Zamer, Waseem El-Huneidi, Mohamed Ahmed Eladl, Jibran Sualeh Muhammad
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	heat shock proteins colorectal carcinoma chaperones theranostics Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ac3dd17d7b0043809401c20d1231e5d5
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spelling	oai:doaj.org-article:ac3dd17d7b0043809401c20d1231e5d52021-11-25T17:08:11ZIns and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives10.3390/cells101128622073-4409https://doaj.org/article/ac3dd17d7b0043809401c20d1231e5d52021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2862https://doaj.org/toc/2073-4409Cancer cells can reprogram their metabolic activities and undergo uncontrolled proliferation by utilizing the power of heat shock proteins (HSPs). HSPs are highly conserved chaperones that facilitate the folding of intracellular proteins under stress. Constitutively, HSPs are expressed at low levels, but their expression upregulates in response to a wide variety of insults, including anticancer drugs, allowing cancer cells to develop chemoresistance. In recent years, several researchers have reported that HSPs could be an important therapeutic target in difficult-to-treat cancers such as colorectal carcinoma (CRC). Worldwide, CRC is the second most common type of cancer and the second leading cause of cancer-related deaths. The molecular complexity of CRC and the coexisting inflammatory conditions present a significant obstacle to developing effective treatment. Recently, considerable progress has been made in enhancing our understanding of the role of HSPs in CRC pathogenesis. Moreover, novel therapeutic strategies targeting HSPs, either alone or in combination with other anticancer agents, have been reported. Herein, we present an overview of the functional mechanisms and the diagnostic and prognostic potential of HSPs in CRC. We also discuss emerging anti-CRC strategies based on targeting HSPs.Batoul Abi ZamerWaseem El-HuneidiMohamed Ahmed EladlJibran Sualeh MuhammadMDPI AGarticleheat shock proteinscolorectal carcinomachaperonestheranosticsBiology (General)QH301-705.5ENCells, Vol 10, Iss 2862, p 2862 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	heat shock proteins colorectal carcinoma chaperones theranostics Biology (General) QH301-705.5
spellingShingle	heat shock proteins colorectal carcinoma chaperones theranostics Biology (General) QH301-705.5 Batoul Abi Zamer Waseem El-Huneidi Mohamed Ahmed Eladl Jibran Sualeh Muhammad Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives
description	Cancer cells can reprogram their metabolic activities and undergo uncontrolled proliferation by utilizing the power of heat shock proteins (HSPs). HSPs are highly conserved chaperones that facilitate the folding of intracellular proteins under stress. Constitutively, HSPs are expressed at low levels, but their expression upregulates in response to a wide variety of insults, including anticancer drugs, allowing cancer cells to develop chemoresistance. In recent years, several researchers have reported that HSPs could be an important therapeutic target in difficult-to-treat cancers such as colorectal carcinoma (CRC). Worldwide, CRC is the second most common type of cancer and the second leading cause of cancer-related deaths. The molecular complexity of CRC and the coexisting inflammatory conditions present a significant obstacle to developing effective treatment. Recently, considerable progress has been made in enhancing our understanding of the role of HSPs in CRC pathogenesis. Moreover, novel therapeutic strategies targeting HSPs, either alone or in combination with other anticancer agents, have been reported. Herein, we present an overview of the functional mechanisms and the diagnostic and prognostic potential of HSPs in CRC. We also discuss emerging anti-CRC strategies based on targeting HSPs.
format	article
author	Batoul Abi Zamer Waseem El-Huneidi Mohamed Ahmed Eladl Jibran Sualeh Muhammad
author_facet	Batoul Abi Zamer Waseem El-Huneidi Mohamed Ahmed Eladl Jibran Sualeh Muhammad
author_sort	Batoul Abi Zamer
title	Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives
title_short	Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives
title_full	Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives
title_fullStr	Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives
title_full_unstemmed	Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives
title_sort	ins and outs of heat shock proteins in colorectal carcinoma: its role in carcinogenesis and therapeutic perspectives
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ac3dd17d7b0043809401c20d1231e5d5
work_keys_str_mv	AT batoulabizamer insandoutsofheatshockproteinsincolorectalcarcinomaitsroleincarcinogenesisandtherapeuticperspectives AT waseemelhuneidi insandoutsofheatshockproteinsincolorectalcarcinomaitsroleincarcinogenesisandtherapeuticperspectives AT mohamedahmedeladl insandoutsofheatshockproteinsincolorectalcarcinomaitsroleincarcinogenesisandtherapeuticperspectives AT jibransualehmuhammad insandoutsofheatshockproteinsincolorectalcarcinomaitsroleincarcinogenesisandtherapeuticperspectives
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Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives

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