Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives

Cancer cells can reprogram their metabolic activities and undergo uncontrolled proliferation by utilizing the power of heat shock proteins (HSPs). HSPs are highly conserved chaperones that facilitate the folding of intracellular proteins under stress. Constitutively, HSPs are expressed at low levels...

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Autores principales: Batoul Abi Zamer, Waseem El-Huneidi, Mohamed Ahmed Eladl, Jibran Sualeh Muhammad
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Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/ac3dd17d7b0043809401c20d1231e5d5
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spelling oai:doaj.org-article:ac3dd17d7b0043809401c20d1231e5d52021-11-25T17:08:11ZIns and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives10.3390/cells101128622073-4409https://doaj.org/article/ac3dd17d7b0043809401c20d1231e5d52021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2862https://doaj.org/toc/2073-4409Cancer cells can reprogram their metabolic activities and undergo uncontrolled proliferation by utilizing the power of heat shock proteins (HSPs). HSPs are highly conserved chaperones that facilitate the folding of intracellular proteins under stress. Constitutively, HSPs are expressed at low levels, but their expression upregulates in response to a wide variety of insults, including anticancer drugs, allowing cancer cells to develop chemoresistance. In recent years, several researchers have reported that HSPs could be an important therapeutic target in difficult-to-treat cancers such as colorectal carcinoma (CRC). Worldwide, CRC is the second most common type of cancer and the second leading cause of cancer-related deaths. The molecular complexity of CRC and the coexisting inflammatory conditions present a significant obstacle to developing effective treatment. Recently, considerable progress has been made in enhancing our understanding of the role of HSPs in CRC pathogenesis. Moreover, novel therapeutic strategies targeting HSPs, either alone or in combination with other anticancer agents, have been reported. Herein, we present an overview of the functional mechanisms and the diagnostic and prognostic potential of HSPs in CRC. We also discuss emerging anti-CRC strategies based on targeting HSPs.Batoul Abi ZamerWaseem El-HuneidiMohamed Ahmed EladlJibran Sualeh MuhammadMDPI AGarticleheat shock proteinscolorectal carcinomachaperonestheranosticsBiology (General)QH301-705.5ENCells, Vol 10, Iss 2862, p 2862 (2021)
institution DOAJ
collection DOAJ
language EN
topic heat shock proteins
colorectal carcinoma
chaperones
theranostics
Biology (General)
QH301-705.5
spellingShingle heat shock proteins
colorectal carcinoma
chaperones
theranostics
Biology (General)
QH301-705.5
Batoul Abi Zamer
Waseem El-Huneidi
Mohamed Ahmed Eladl
Jibran Sualeh Muhammad
Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives
description Cancer cells can reprogram their metabolic activities and undergo uncontrolled proliferation by utilizing the power of heat shock proteins (HSPs). HSPs are highly conserved chaperones that facilitate the folding of intracellular proteins under stress. Constitutively, HSPs are expressed at low levels, but their expression upregulates in response to a wide variety of insults, including anticancer drugs, allowing cancer cells to develop chemoresistance. In recent years, several researchers have reported that HSPs could be an important therapeutic target in difficult-to-treat cancers such as colorectal carcinoma (CRC). Worldwide, CRC is the second most common type of cancer and the second leading cause of cancer-related deaths. The molecular complexity of CRC and the coexisting inflammatory conditions present a significant obstacle to developing effective treatment. Recently, considerable progress has been made in enhancing our understanding of the role of HSPs in CRC pathogenesis. Moreover, novel therapeutic strategies targeting HSPs, either alone or in combination with other anticancer agents, have been reported. Herein, we present an overview of the functional mechanisms and the diagnostic and prognostic potential of HSPs in CRC. We also discuss emerging anti-CRC strategies based on targeting HSPs.
format article
author Batoul Abi Zamer
Waseem El-Huneidi
Mohamed Ahmed Eladl
Jibran Sualeh Muhammad
author_facet Batoul Abi Zamer
Waseem El-Huneidi
Mohamed Ahmed Eladl
Jibran Sualeh Muhammad
author_sort Batoul Abi Zamer
title Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives
title_short Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives
title_full Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives
title_fullStr Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives
title_full_unstemmed Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives
title_sort ins and outs of heat shock proteins in colorectal carcinoma: its role in carcinogenesis and therapeutic perspectives
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/ac3dd17d7b0043809401c20d1231e5d5
work_keys_str_mv AT batoulabizamer insandoutsofheatshockproteinsincolorectalcarcinomaitsroleincarcinogenesisandtherapeuticperspectives
AT waseemelhuneidi insandoutsofheatshockproteinsincolorectalcarcinomaitsroleincarcinogenesisandtherapeuticperspectives
AT mohamedahmedeladl insandoutsofheatshockproteinsincolorectalcarcinomaitsroleincarcinogenesisandtherapeuticperspectives
AT jibransualehmuhammad insandoutsofheatshockproteinsincolorectalcarcinomaitsroleincarcinogenesisandtherapeuticperspectives
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