Signaling Peptide SpoV Is Essential for Streptococcus pyogenes Virulence, and Prophylaxis with Anti-SpoV Decreases Disease Severity

Streptococcal peptide of virulence (SpoV) is a Streptococcus pyogenes (group A streptococcus (GAS))-specific peptide that is important for GAS survival in murine blood, and the expression of the virulence factors streptolysin O (slo) and streptolysin S (...

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Autores principales:	Andrea L. Herrera, Michael S. Chaussee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Streptococcus pyogenes</i> SpoV virulence iGAS antibody therapy Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ac3e5d64c9f644fa80047f3a0d02ae28
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spelling	oai:doaj.org-article:ac3e5d64c9f644fa80047f3a0d02ae282021-11-25T18:25:06ZSignaling Peptide SpoV Is Essential for <i>Streptococcus pyogenes</i> Virulence, and Prophylaxis with Anti-SpoV Decreases Disease Severity10.3390/microorganisms91123212076-2607https://doaj.org/article/ac3e5d64c9f644fa80047f3a0d02ae282021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2321https://doaj.org/toc/2076-2607Streptococcal peptide of virulence (SpoV) is a <i>Streptococcus pyogenes</i> (group A streptococcus (GAS))-specific peptide that is important for GAS survival in murine blood, and the expression of the virulence factors streptolysin O (<i>slo</i>) and streptolysin S (<i>sagA</i>). We used a <i>spoV</i> mutant in isolate MGAS315 to assess the contribution of the SpoV peptide to virulence by using a murine model of invasive disease and an ex vivo human model (Lancefield assay). We then used antibodies to SpoV in both models to evaluate their ability to decrease morbidity and mortality. Results showed that SpoV is essential for GAS virulence, and targeting the peptide has therapeutic potential.Andrea L. HerreraMichael S. ChausseeMDPI AGarticle<i>Streptococcus pyogenes</i>SpoVvirulenceiGASantibody therapyBiology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2321, p 2321 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Streptococcus pyogenes</i> SpoV virulence iGAS antibody therapy Biology (General) QH301-705.5
spellingShingle	<i>Streptococcus pyogenes</i> SpoV virulence iGAS antibody therapy Biology (General) QH301-705.5 Andrea L. Herrera Michael S. Chaussee Signaling Peptide SpoV Is Essential for <i>Streptococcus pyogenes</i> Virulence, and Prophylaxis with Anti-SpoV Decreases Disease Severity
description	Streptococcal peptide of virulence (SpoV) is a <i>Streptococcus pyogenes</i> (group A streptococcus (GAS))-specific peptide that is important for GAS survival in murine blood, and the expression of the virulence factors streptolysin O (<i>slo</i>) and streptolysin S (<i>sagA</i>). We used a <i>spoV</i> mutant in isolate MGAS315 to assess the contribution of the SpoV peptide to virulence by using a murine model of invasive disease and an ex vivo human model (Lancefield assay). We then used antibodies to SpoV in both models to evaluate their ability to decrease morbidity and mortality. Results showed that SpoV is essential for GAS virulence, and targeting the peptide has therapeutic potential.
format	article
author	Andrea L. Herrera Michael S. Chaussee
author_facet	Andrea L. Herrera Michael S. Chaussee
author_sort	Andrea L. Herrera
title	Signaling Peptide SpoV Is Essential for <i>Streptococcus pyogenes</i> Virulence, and Prophylaxis with Anti-SpoV Decreases Disease Severity
title_short	Signaling Peptide SpoV Is Essential for <i>Streptococcus pyogenes</i> Virulence, and Prophylaxis with Anti-SpoV Decreases Disease Severity
title_full	Signaling Peptide SpoV Is Essential for <i>Streptococcus pyogenes</i> Virulence, and Prophylaxis with Anti-SpoV Decreases Disease Severity
title_fullStr	Signaling Peptide SpoV Is Essential for <i>Streptococcus pyogenes</i> Virulence, and Prophylaxis with Anti-SpoV Decreases Disease Severity
title_full_unstemmed	Signaling Peptide SpoV Is Essential for <i>Streptococcus pyogenes</i> Virulence, and Prophylaxis with Anti-SpoV Decreases Disease Severity
title_sort	signaling peptide spov is essential for <i>streptococcus pyogenes</i> virulence, and prophylaxis with anti-spov decreases disease severity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ac3e5d64c9f644fa80047f3a0d02ae28
work_keys_str_mv	AT andrealherrera signalingpeptidespovisessentialforistreptococcuspyogenesivirulenceandprophylaxiswithantispovdecreasesdiseaseseverity AT michaelschaussee signalingpeptidespovisessentialforistreptococcuspyogenesivirulenceandprophylaxiswithantispovdecreasesdiseaseseverity
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Signaling Peptide SpoV Is Essential for <i>Streptococcus pyogenes</i> Virulence, and Prophylaxis with Anti-SpoV Decreases Disease Severity

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