Gambogic Acid as a Candidate for Cancer Therapy: A Review

Yuling Liu,1 Yingchong Chen,2 Longfei Lin,1 Hui Li1 1Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 2Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine,...

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Autores principales:	Liu Y, Chen Y, Lin L, Li H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	gambogic acid anti-cancer activities drug delivery systems combination therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ac4214d69e264805be36592171e7fd72
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spelling	oai:doaj.org-article:ac4214d69e264805be36592171e7fd722021-12-02T13:57:25ZGambogic Acid as a Candidate for Cancer Therapy: A Review1178-2013https://doaj.org/article/ac4214d69e264805be36592171e7fd722020-12-01T00:00:00Zhttps://www.dovepress.com/gambogic-acid-as-a-candidate-for-cancer-therapy-a-review-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yuling Liu,1 Yingchong Chen,2 Longfei Lin,1 Hui Li1 1Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 2Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, People’s Republic of ChinaCorrespondence: Hui LiInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 16 Nanxiao Street, Dongzhimen, Dongcheng District, Beijing, People’s Republic of ChinaEmail lihuizys@126.comAbstract: Gambogic acid (GA), a kind of dry resin secreted by the Garcinia hanburyi tree, is a natural active ingredient with various biological activities, such as anti-cancer, anti-inflammatory, antioxidant, anti-bacterial effects, etc. An increasing amount of evidence indicates that GA has obvious anti-cancer effects via various molecular mechanisms, including the induction of apoptosis, autophagy, cell cycle arrest and the inhibition of invasion, metastasis, angiogenesis. In order to improve the efficacy in cancer treatment, nanometer drug delivery systems have been employed to load GA and form micelles, nanoparticles, nanofibers, and so on. In this review, we aim to offer a summary of chemical structure and properties, anti-cancer activities, drug delivery systems and combination therapy of GA, which might provide a reference to promote the development and clinical application of GA.Keywords: gambogic acid, anti-cancer activities, drug delivery systems, combination therapyLiu YChen YLin LLi HDove Medical Pressarticlegambogic acidanti-cancer activitiesdrug delivery systemscombination therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 10385-10399 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	gambogic acid anti-cancer activities drug delivery systems combination therapy Medicine (General) R5-920
spellingShingle	gambogic acid anti-cancer activities drug delivery systems combination therapy Medicine (General) R5-920 Liu Y Chen Y Lin L Li H Gambogic Acid as a Candidate for Cancer Therapy: A Review
description	Yuling Liu,1 Yingchong Chen,2 Longfei Lin,1 Hui Li1 1Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 2Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, People’s Republic of ChinaCorrespondence: Hui LiInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 16 Nanxiao Street, Dongzhimen, Dongcheng District, Beijing, People’s Republic of ChinaEmail lihuizys@126.comAbstract: Gambogic acid (GA), a kind of dry resin secreted by the Garcinia hanburyi tree, is a natural active ingredient with various biological activities, such as anti-cancer, anti-inflammatory, antioxidant, anti-bacterial effects, etc. An increasing amount of evidence indicates that GA has obvious anti-cancer effects via various molecular mechanisms, including the induction of apoptosis, autophagy, cell cycle arrest and the inhibition of invasion, metastasis, angiogenesis. In order to improve the efficacy in cancer treatment, nanometer drug delivery systems have been employed to load GA and form micelles, nanoparticles, nanofibers, and so on. In this review, we aim to offer a summary of chemical structure and properties, anti-cancer activities, drug delivery systems and combination therapy of GA, which might provide a reference to promote the development and clinical application of GA.Keywords: gambogic acid, anti-cancer activities, drug delivery systems, combination therapy
format	article
author	Liu Y Chen Y Lin L Li H
author_facet	Liu Y Chen Y Lin L Li H
author_sort	Liu Y
title	Gambogic Acid as a Candidate for Cancer Therapy: A Review
title_short	Gambogic Acid as a Candidate for Cancer Therapy: A Review
title_full	Gambogic Acid as a Candidate for Cancer Therapy: A Review
title_fullStr	Gambogic Acid as a Candidate for Cancer Therapy: A Review
title_full_unstemmed	Gambogic Acid as a Candidate for Cancer Therapy: A Review
title_sort	gambogic acid as a candidate for cancer therapy: a review
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/ac4214d69e264805be36592171e7fd72
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Gambogic Acid as a Candidate for Cancer Therapy: A Review

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