The Charlson Comorbidity Index is associated with risk of 30-day mortality in patients with myocardial injury after non-cardiac surgery

Abstract Myocardial injury after non-cardiac surgery (MINS) is a well-known and relevant indicator of early postoperative mortality, but factors related to increased mortality in MINS patients are as yet unknown. The Charlson Comorbidity Index (CCI) is widely used to classify various comorbid condit...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sojin Kim, Jungchan Park, Ji-Hye Kwon, Ah Ran Oh, Joonhee Gook, Kwangmo Yang, Jin-ho Choi, Kyunga Kim, Ji Dong Sung, Joonghyun Ahn, Seung-Hwa Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ac428d2b7312406e9b8611038abaab59
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ac428d2b7312406e9b8611038abaab59
record_format	dspace
spelling	oai:doaj.org-article:ac428d2b7312406e9b8611038abaab592021-12-02T15:14:47ZThe Charlson Comorbidity Index is associated with risk of 30-day mortality in patients with myocardial injury after non-cardiac surgery10.1038/s41598-021-98026-42045-2322https://doaj.org/article/ac428d2b7312406e9b8611038abaab592021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98026-4https://doaj.org/toc/2045-2322Abstract Myocardial injury after non-cardiac surgery (MINS) is a well-known and relevant indicator of early postoperative mortality, but factors related to increased mortality in MINS patients are as yet unknown. The Charlson Comorbidity Index (CCI) is widely used to classify various comorbid conditions and underlying diseases. Our study aimed to determine the prognostic value of CCI with regard to mortality of patients with MINS. This study comprises 5633 patients who had MINS as diagnosed by a rise of postoperative cardiac troponin I above the normal range (≥ 0.04 ng/mL) from January 2010 to June 2019. Patients were divided into two groups according to median weighted CCI score: low CCI (≤ 2) and high CCI (> 2) groups. The primary outcome was 30-day mortality after surgery, and secondary outcomes were 1-year and overall mortalities. Of the 5633 patients, 3428 (60.9%) were in the low CCI group (1.21 ± 0.84) and 2205 (39.1%) were in the high CCI group (4.17 ± 1.82). After propensity score matching, mortality during the first 30 days after surgery was significantly greater in the high CCI group than the low CCI group (9.4% vs. 6.0%, respectively; hazard ratio 1.56, 95% confidence interval 1.23–1.98, p < 0.001). A high CCI score was associated with increased 30-day mortality in patients with MINS, suggesting that the CCI may need to be considered when predicting outcomes of MINS patients.Sojin KimJungchan ParkJi-Hye KwonAh Ran OhJoonhee GookKwangmo YangJin-ho ChoiKyunga KimJi Dong SungJoonghyun AhnSeung-Hwa LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sojin Kim Jungchan Park Ji-Hye Kwon Ah Ran Oh Joonhee Gook Kwangmo Yang Jin-ho Choi Kyunga Kim Ji Dong Sung Joonghyun Ahn Seung-Hwa Lee The Charlson Comorbidity Index is associated with risk of 30-day mortality in patients with myocardial injury after non-cardiac surgery
description	Abstract Myocardial injury after non-cardiac surgery (MINS) is a well-known and relevant indicator of early postoperative mortality, but factors related to increased mortality in MINS patients are as yet unknown. The Charlson Comorbidity Index (CCI) is widely used to classify various comorbid conditions and underlying diseases. Our study aimed to determine the prognostic value of CCI with regard to mortality of patients with MINS. This study comprises 5633 patients who had MINS as diagnosed by a rise of postoperative cardiac troponin I above the normal range (≥ 0.04 ng/mL) from January 2010 to June 2019. Patients were divided into two groups according to median weighted CCI score: low CCI (≤ 2) and high CCI (> 2) groups. The primary outcome was 30-day mortality after surgery, and secondary outcomes were 1-year and overall mortalities. Of the 5633 patients, 3428 (60.9%) were in the low CCI group (1.21 ± 0.84) and 2205 (39.1%) were in the high CCI group (4.17 ± 1.82). After propensity score matching, mortality during the first 30 days after surgery was significantly greater in the high CCI group than the low CCI group (9.4% vs. 6.0%, respectively; hazard ratio 1.56, 95% confidence interval 1.23–1.98, p < 0.001). A high CCI score was associated with increased 30-day mortality in patients with MINS, suggesting that the CCI may need to be considered when predicting outcomes of MINS patients.
format	article
author	Sojin Kim Jungchan Park Ji-Hye Kwon Ah Ran Oh Joonhee Gook Kwangmo Yang Jin-ho Choi Kyunga Kim Ji Dong Sung Joonghyun Ahn Seung-Hwa Lee
author_facet	Sojin Kim Jungchan Park Ji-Hye Kwon Ah Ran Oh Joonhee Gook Kwangmo Yang Jin-ho Choi Kyunga Kim Ji Dong Sung Joonghyun Ahn Seung-Hwa Lee
author_sort	Sojin Kim
title	The Charlson Comorbidity Index is associated with risk of 30-day mortality in patients with myocardial injury after non-cardiac surgery
title_short	The Charlson Comorbidity Index is associated with risk of 30-day mortality in patients with myocardial injury after non-cardiac surgery
title_full	The Charlson Comorbidity Index is associated with risk of 30-day mortality in patients with myocardial injury after non-cardiac surgery
title_fullStr	The Charlson Comorbidity Index is associated with risk of 30-day mortality in patients with myocardial injury after non-cardiac surgery
title_full_unstemmed	The Charlson Comorbidity Index is associated with risk of 30-day mortality in patients with myocardial injury after non-cardiac surgery
title_sort	charlson comorbidity index is associated with risk of 30-day mortality in patients with myocardial injury after non-cardiac surgery
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ac428d2b7312406e9b8611038abaab59
work_keys_str_mv	AT sojinkim thecharlsoncomorbidityindexisassociatedwithriskof30daymortalityinpatientswithmyocardialinjuryafternoncardiacsurgery AT jungchanpark thecharlsoncomorbidityindexisassociatedwithriskof30daymortalityinpatientswithmyocardialinjuryafternoncardiacsurgery AT jihyekwon thecharlsoncomorbidityindexisassociatedwithriskof30daymortalityinpatientswithmyocardialinjuryafternoncardiacsurgery AT ahranoh thecharlsoncomorbidityindexisassociatedwithriskof30daymortalityinpatientswithmyocardialinjuryafternoncardiacsurgery AT joonheegook thecharlsoncomorbidityindexisassociatedwithriskof30daymortalityinpatientswithmyocardialinjuryafternoncardiacsurgery AT kwangmoyang thecharlsoncomorbidityindexisassociatedwithriskof30daymortalityinpatientswithmyocardialinjuryafternoncardiacsurgery AT jinhochoi thecharlsoncomorbidityindexisassociatedwithriskof30daymortalityinpatientswithmyocardialinjuryafternoncardiacsurgery AT kyungakim thecharlsoncomorbidityindexisassociatedwithriskof30daymortalityinpatientswithmyocardialinjuryafternoncardiacsurgery AT jidongsung thecharlsoncomorbidityindexisassociatedwithriskof30daymortalityinpatientswithmyocardialinjuryafternoncardiacsurgery AT joonghyunahn thecharlsoncomorbidityindexisassociatedwithriskof30daymortalityinpatientswithmyocardialinjuryafternoncardiacsurgery AT seunghwalee thecharlsoncomorbidityindexisassociatedwithriskof30daymortalityinpatientswithmyocardialinjuryafternoncardiacsurgery AT sojinkim charlsoncomorbidityindexisassociatedwithriskof30daymortalityinpatientswithmyocardialinjuryafternoncardiacsurgery AT jungchanpark charlsoncomorbidityindexisassociatedwithriskof30daymortalityinpatientswithmyocardialinjuryafternoncardiacsurgery AT jihyekwon charlsoncomorbidityindexisassociatedwithriskof30daymortalityinpatientswithmyocardialinjuryafternoncardiacsurgery AT ahranoh charlsoncomorbidityindexisassociatedwithriskof30daymortalityinpatientswithmyocardialinjuryafternoncardiacsurgery AT joonheegook charlsoncomorbidityindexisassociatedwithriskof30daymortalityinpatientswithmyocardialinjuryafternoncardiacsurgery AT kwangmoyang charlsoncomorbidityindexisassociatedwithriskof30daymortalityinpatientswithmyocardialinjuryafternoncardiacsurgery AT jinhochoi charlsoncomorbidityindexisassociatedwithriskof30daymortalityinpatientswithmyocardialinjuryafternoncardiacsurgery AT kyungakim charlsoncomorbidityindexisassociatedwithriskof30daymortalityinpatientswithmyocardialinjuryafternoncardiacsurgery AT jidongsung charlsoncomorbidityindexisassociatedwithriskof30daymortalityinpatientswithmyocardialinjuryafternoncardiacsurgery AT joonghyunahn charlsoncomorbidityindexisassociatedwithriskof30daymortalityinpatientswithmyocardialinjuryafternoncardiacsurgery AT seunghwalee charlsoncomorbidityindexisassociatedwithriskof30daymortalityinpatientswithmyocardialinjuryafternoncardiacsurgery
_version_	1718387592193376256

The Charlson Comorbidity Index is associated with risk of 30-day mortality in patients with myocardial injury after non-cardiac surgery

Ejemplares similares