Quantitative SUMO proteomics identifies PIAS1 substrates involved in cell migration and motility

PIAS1 is an E3 SUMO ligase involved in various cellular processes. Here, the authors use quantitative proteomics to identify potential PIAS1 substrates in human cells and elucidate the biological consequences of PIAS1-mediated SUMOylation of vimentin.

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Detalles Bibliográficos
Autores principales: Chongyang Li, Francis P. McManus, Cédric Plutoni, Cristina Mirela Pascariu, Trent Nelson, Lara Elis Alberici Delsin, Gregory Emery, Pierre Thibault
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/ac44f97edfdb415aac4d3879661d3d3c
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Sumario:PIAS1 is an E3 SUMO ligase involved in various cellular processes. Here, the authors use quantitative proteomics to identify potential PIAS1 substrates in human cells and elucidate the biological consequences of PIAS1-mediated SUMOylation of vimentin.