PROTECTIVE EFFECT OF URTICA DIOICA ON RENAL MORPHOMETRIC AND HISTOLOGIC ALTERATIONS IN STREPTOZOTOCIN DIABETIC RATS

BACKGROUND AND OBJECTIVE: Hyperglycemia causes renal morphometric and histological alterations. This study was done to determine the protective role of urtica dioica on renal morphometric and histological alterations in streptozotocin diabetic rats.METHODS: Thirty adult Wistar rats divided into thre...

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Autores principales:	MJ Golalipour, A Mohammad Gharravi, S Ghafari, R Azarhoush
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2009
Materias:	urtica dioica diabetes blood glucose kidney glomerular hyperglycemia streptozotocin Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ac46c0c895ed45feb03a72b1c210d7d3
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spelling	oai:doaj.org-article:ac46c0c895ed45feb03a72b1c210d7d32021-11-10T09:02:27ZPROTECTIVE EFFECT OF URTICA DIOICA ON RENAL MORPHOMETRIC AND HISTOLOGIC ALTERATIONS IN STREPTOZOTOCIN DIABETIC RATS1561-41072251-7170https://doaj.org/article/ac46c0c895ed45feb03a72b1c210d7d32009-01-01T00:00:00Zhttp://jbums.org/article-1-3108-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Hyperglycemia causes renal morphometric and histological alterations. This study was done to determine the protective role of urtica dioica on renal morphometric and histological alterations in streptozotocin diabetic rats.METHODS: Thirty adult Wistar rats divided into three groups. Group I normal control group, group II: diabetic group animal received 80 mgkg STZ (streptozotocin) by intraperitoneally and group III: protective group, rats received 100 mg/kg daily hydroalcoholic extract of U. dioica for 5 days then diabetes induced in animals by STZ. In the end of five weeks the animals had been scarified, the kidneys fixed by buffer formaldehyde, processed, sectioned and stained with H;E. FINDINGS: Mean of blood glucose concentrations in end of fifth weeks were 99.4, 454.7 and 303.6 in control, diabetic and protective groups, respectively (p<0.05), that was lower in protective group than diabetic group. Ration of kidney/body weight in control, diabetes and protective group were 0.42, 0.51 and 0.48, respectively (p<0.05). Glomerular area in control, diabetes and protective group were 1335.3, 1441.8 and 1326.4 µm2, respectively (p<0.05). Glomerular diameter in diabetic group (162.2 µm) was higher than control (156.1) and protective group (153.2). Pathology finding as glomerular sclerosis was seen in diabetic group but this finding did not observe in control and protective groups.CONCLUSION: This study demonstrated that administration of urtica dioica before streptozotocin-induced diabetes has protective effects on blood glucose, renal morphometric and histological alterations in streptozotocin diabetic rats.MJ GolalipourA Mohammad GharraviS Ghafari,R AzarhoushBabol University of Medical Sciencesarticleurtica dioicadiabetesblood glucosekidneyglomerularhyperglycemiastreptozotocinMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 10, Iss 6, Pp 14-22 (2009)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	urtica dioica diabetes blood glucose kidney glomerular hyperglycemia streptozotocin Medicine R Medicine (General) R5-920
spellingShingle	urtica dioica diabetes blood glucose kidney glomerular hyperglycemia streptozotocin Medicine R Medicine (General) R5-920 MJ Golalipour A Mohammad Gharravi S Ghafari, R Azarhoush PROTECTIVE EFFECT OF URTICA DIOICA ON RENAL MORPHOMETRIC AND HISTOLOGIC ALTERATIONS IN STREPTOZOTOCIN DIABETIC RATS
description	BACKGROUND AND OBJECTIVE: Hyperglycemia causes renal morphometric and histological alterations. This study was done to determine the protective role of urtica dioica on renal morphometric and histological alterations in streptozotocin diabetic rats.METHODS: Thirty adult Wistar rats divided into three groups. Group I normal control group, group II: diabetic group animal received 80 mgkg STZ (streptozotocin) by intraperitoneally and group III: protective group, rats received 100 mg/kg daily hydroalcoholic extract of U. dioica for 5 days then diabetes induced in animals by STZ. In the end of five weeks the animals had been scarified, the kidneys fixed by buffer formaldehyde, processed, sectioned and stained with H;E. FINDINGS: Mean of blood glucose concentrations in end of fifth weeks were 99.4, 454.7 and 303.6 in control, diabetic and protective groups, respectively (p<0.05), that was lower in protective group than diabetic group. Ration of kidney/body weight in control, diabetes and protective group were 0.42, 0.51 and 0.48, respectively (p<0.05). Glomerular area in control, diabetes and protective group were 1335.3, 1441.8 and 1326.4 µm2, respectively (p<0.05). Glomerular diameter in diabetic group (162.2 µm) was higher than control (156.1) and protective group (153.2). Pathology finding as glomerular sclerosis was seen in diabetic group but this finding did not observe in control and protective groups.CONCLUSION: This study demonstrated that administration of urtica dioica before streptozotocin-induced diabetes has protective effects on blood glucose, renal morphometric and histological alterations in streptozotocin diabetic rats.
format	article
author	MJ Golalipour A Mohammad Gharravi S Ghafari, R Azarhoush
author_facet	MJ Golalipour A Mohammad Gharravi S Ghafari, R Azarhoush
author_sort	MJ Golalipour
title	PROTECTIVE EFFECT OF URTICA DIOICA ON RENAL MORPHOMETRIC AND HISTOLOGIC ALTERATIONS IN STREPTOZOTOCIN DIABETIC RATS
title_short	PROTECTIVE EFFECT OF URTICA DIOICA ON RENAL MORPHOMETRIC AND HISTOLOGIC ALTERATIONS IN STREPTOZOTOCIN DIABETIC RATS
title_full	PROTECTIVE EFFECT OF URTICA DIOICA ON RENAL MORPHOMETRIC AND HISTOLOGIC ALTERATIONS IN STREPTOZOTOCIN DIABETIC RATS
title_fullStr	PROTECTIVE EFFECT OF URTICA DIOICA ON RENAL MORPHOMETRIC AND HISTOLOGIC ALTERATIONS IN STREPTOZOTOCIN DIABETIC RATS
title_full_unstemmed	PROTECTIVE EFFECT OF URTICA DIOICA ON RENAL MORPHOMETRIC AND HISTOLOGIC ALTERATIONS IN STREPTOZOTOCIN DIABETIC RATS
title_sort	protective effect of urtica dioica on renal morphometric and histologic alterations in streptozotocin diabetic rats
publisher	Babol University of Medical Sciences
publishDate	2009
url	https://doaj.org/article/ac46c0c895ed45feb03a72b1c210d7d3
work_keys_str_mv	AT mjgolalipour protectiveeffectofurticadioicaonrenalmorphometricandhistologicalterationsinstreptozotocindiabeticrats AT amohammadgharravi protectiveeffectofurticadioicaonrenalmorphometricandhistologicalterationsinstreptozotocindiabeticrats AT sghafari protectiveeffectofurticadioicaonrenalmorphometricandhistologicalterationsinstreptozotocindiabeticrats AT razarhoush protectiveeffectofurticadioicaonrenalmorphometricandhistologicalterationsinstreptozotocindiabeticrats
_version_	1718440319577489408

PROTECTIVE EFFECT OF URTICA DIOICA ON RENAL MORPHOMETRIC AND HISTOLOGIC ALTERATIONS IN STREPTOZOTOCIN DIABETIC RATS

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