Rare Polyene-polyol Macrolides from Mangrove-derived Streptomyces sp. ZQ4BG

Abstract Bioactive natural products from mangrove-derived actinomycetes are important sources for discovery of drug lead compounds. In this study, an extract prepared from culture of an actinomycete Streptomyces sp. ZQ4BG isolated from mangrove soils was found to have activity in inhibiting prolifer...

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Autores principales:	Wenling Wang, Tengfei Song, Weiyun Chai, Lu Chen, Lei Chen, Xiao-Yuan Lian, Zhizhen Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ac49d7a9c0fa4768a64f8e6af31a0a55
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spelling	oai:doaj.org-article:ac49d7a9c0fa4768a64f8e6af31a0a552021-12-02T16:06:33ZRare Polyene-polyol Macrolides from Mangrove-derived Streptomyces sp. ZQ4BG10.1038/s41598-017-01912-z2045-2322https://doaj.org/article/ac49d7a9c0fa4768a64f8e6af31a0a552017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01912-zhttps://doaj.org/toc/2045-2322Abstract Bioactive natural products from mangrove-derived actinomycetes are important sources for discovery of drug lead compounds. In this study, an extract prepared from culture of an actinomycete Streptomyces sp. ZQ4BG isolated from mangrove soils was found to have activity in inhibiting proliferation of glioma cells. Large culture of this mangrove actinomycete in Gause’s liquid medium resulted in isolation of seven novel polyene-polyol macrolides, named as flavofungins III–IX (3–9), together with known flavofungins I (1) and II (2) and spectinabilin (10). Structures of these isolated compounds were elucidated by extensive NMR analyses and HRESIMS data. The stereochemical assignments were achieved by a combination of NOE information, universal NMR database, and chemical reactions including preparation of acetonide derivatives and Mosher esters. Flavofungins IV–VIII (4–8) are rare 32-membered polyene-polyol macrolides with a tetrahydrofuran ring, while flavofungin IX (9) represents the first example of this type of macrolide with a unique oxepane ring. Flavofungins I (1) and II (2) and spectinabilin (10) showed anti-glioma and antifungal activities.Wenling WangTengfei SongWeiyun ChaiLu ChenLei ChenXiao-Yuan LianZhizhen ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wenling Wang Tengfei Song Weiyun Chai Lu Chen Lei Chen Xiao-Yuan Lian Zhizhen Zhang Rare Polyene-polyol Macrolides from Mangrove-derived Streptomyces sp. ZQ4BG
description	Abstract Bioactive natural products from mangrove-derived actinomycetes are important sources for discovery of drug lead compounds. In this study, an extract prepared from culture of an actinomycete Streptomyces sp. ZQ4BG isolated from mangrove soils was found to have activity in inhibiting proliferation of glioma cells. Large culture of this mangrove actinomycete in Gause’s liquid medium resulted in isolation of seven novel polyene-polyol macrolides, named as flavofungins III–IX (3–9), together with known flavofungins I (1) and II (2) and spectinabilin (10). Structures of these isolated compounds were elucidated by extensive NMR analyses and HRESIMS data. The stereochemical assignments were achieved by a combination of NOE information, universal NMR database, and chemical reactions including preparation of acetonide derivatives and Mosher esters. Flavofungins IV–VIII (4–8) are rare 32-membered polyene-polyol macrolides with a tetrahydrofuran ring, while flavofungin IX (9) represents the first example of this type of macrolide with a unique oxepane ring. Flavofungins I (1) and II (2) and spectinabilin (10) showed anti-glioma and antifungal activities.
format	article
author	Wenling Wang Tengfei Song Weiyun Chai Lu Chen Lei Chen Xiao-Yuan Lian Zhizhen Zhang
author_facet	Wenling Wang Tengfei Song Weiyun Chai Lu Chen Lei Chen Xiao-Yuan Lian Zhizhen Zhang
author_sort	Wenling Wang
title	Rare Polyene-polyol Macrolides from Mangrove-derived Streptomyces sp. ZQ4BG
title_short	Rare Polyene-polyol Macrolides from Mangrove-derived Streptomyces sp. ZQ4BG
title_full	Rare Polyene-polyol Macrolides from Mangrove-derived Streptomyces sp. ZQ4BG
title_fullStr	Rare Polyene-polyol Macrolides from Mangrove-derived Streptomyces sp. ZQ4BG
title_full_unstemmed	Rare Polyene-polyol Macrolides from Mangrove-derived Streptomyces sp. ZQ4BG
title_sort	rare polyene-polyol macrolides from mangrove-derived streptomyces sp. zq4bg
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ac49d7a9c0fa4768a64f8e6af31a0a55
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Rare Polyene-polyol Macrolides from Mangrove-derived Streptomyces sp. ZQ4BG

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