Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis

The molecular mechanisms mediating the impact of environmental factors in atherosclerosis are unclear. Here, the authors examine CD14+ blood monocyte’s transcriptome and epigenome signatures to find differential methylation and expression of ARID5B to be associated with human atherosclerosis.

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Autores principales:	Yongmei Liu, Lindsay M. Reynolds, Jingzhong Ding, Li Hou, Kurt Lohman, Tracey Young, Wei Cui, Zhiqing Huang, Carole Grenier, Ma Wan, Hendrik G. Stunnenberg, David Siscovick, Lifang Hou, Bruce M. Psaty, Stephen S. Rich, Jerome I. Rotter, Joel D. Kaufman, Gregory L. Burke, Susan Murphy, David R. Jacobs, Wendy Post, Ina Hoeschele, Douglas A. Bell, David Herrington, John S. Parks, Russell P. Tracy, Charles E. McCall, James H. Stein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ac550ee42c704e9ea9413177742ac970
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spelling	oai:doaj.org-article:ac550ee42c704e9ea9413177742ac9702021-12-02T14:41:08ZBlood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis10.1038/s41467-017-00517-42041-1723https://doaj.org/article/ac550ee42c704e9ea9413177742ac9702017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00517-4https://doaj.org/toc/2041-1723The molecular mechanisms mediating the impact of environmental factors in atherosclerosis are unclear. Here, the authors examine CD14+ blood monocyte’s transcriptome and epigenome signatures to find differential methylation and expression of ARID5B to be associated with human atherosclerosis.Yongmei LiuLindsay M. ReynoldsJingzhong DingLi HouKurt LohmanTracey YoungWei CuiZhiqing HuangCarole GrenierMa WanHendrik G. StunnenbergDavid SiscovickLifang HouBruce M. PsatyStephen S. RichJerome I. RotterJoel D. KaufmanGregory L. BurkeSusan MurphyDavid R. JacobsWendy PostIna HoescheleDouglas A. BellDavid HerringtonJohn S. ParksRussell P. TracyCharles E. McCallJames H. SteinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yongmei Liu Lindsay M. Reynolds Jingzhong Ding Li Hou Kurt Lohman Tracey Young Wei Cui Zhiqing Huang Carole Grenier Ma Wan Hendrik G. Stunnenberg David Siscovick Lifang Hou Bruce M. Psaty Stephen S. Rich Jerome I. Rotter Joel D. Kaufman Gregory L. Burke Susan Murphy David R. Jacobs Wendy Post Ina Hoeschele Douglas A. Bell David Herrington John S. Parks Russell P. Tracy Charles E. McCall James H. Stein Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis
description	The molecular mechanisms mediating the impact of environmental factors in atherosclerosis are unclear. Here, the authors examine CD14+ blood monocyte’s transcriptome and epigenome signatures to find differential methylation and expression of ARID5B to be associated with human atherosclerosis.
format	article
author	Yongmei Liu Lindsay M. Reynolds Jingzhong Ding Li Hou Kurt Lohman Tracey Young Wei Cui Zhiqing Huang Carole Grenier Ma Wan Hendrik G. Stunnenberg David Siscovick Lifang Hou Bruce M. Psaty Stephen S. Rich Jerome I. Rotter Joel D. Kaufman Gregory L. Burke Susan Murphy David R. Jacobs Wendy Post Ina Hoeschele Douglas A. Bell David Herrington John S. Parks Russell P. Tracy Charles E. McCall James H. Stein
author_facet	Yongmei Liu Lindsay M. Reynolds Jingzhong Ding Li Hou Kurt Lohman Tracey Young Wei Cui Zhiqing Huang Carole Grenier Ma Wan Hendrik G. Stunnenberg David Siscovick Lifang Hou Bruce M. Psaty Stephen S. Rich Jerome I. Rotter Joel D. Kaufman Gregory L. Burke Susan Murphy David R. Jacobs Wendy Post Ina Hoeschele Douglas A. Bell David Herrington John S. Parks Russell P. Tracy Charles E. McCall James H. Stein
author_sort	Yongmei Liu
title	Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis
title_short	Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis
title_full	Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis
title_fullStr	Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis
title_full_unstemmed	Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis
title_sort	blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ac550ee42c704e9ea9413177742ac970
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Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis

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