A Prospective Observational Study of Clinicopathological and Biochemical Profile of Patients with Cholecystitis Visiting a Teaching Tertiary Care Centre of Haryana

Introduction Gallstone diseases constitute a major part of patients visiting hospitals, and more than 50% of operation theaters are occupied by it or diseases related to it. It also imposes significant financial burden on health resources. The 21st century has opened with an improved foundation to o...

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Autores principales: Pushpendra Malik, L.N.U. Tarun, Sanjeet Singh, Mahinder K Garg, Mukesh Sangwan, Rahul Kumar, Sebin Sebastian
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Publicado: Thieme Medical and Scientific Publishers Pvt. Ltd. 2021
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spelling oai:doaj.org-article:ac590b7ca3424998bb97370e4d785ef32021-11-29T23:31:05ZA Prospective Observational Study of Clinicopathological and Biochemical Profile of Patients with Cholecystitis Visiting a Teaching Tertiary Care Centre of Haryana2455-74202455-094910.1055/s-0041-1731114https://doaj.org/article/ac590b7ca3424998bb97370e4d785ef32021-06-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1731114https://doaj.org/toc/2455-7420https://doaj.org/toc/2455-0949Introduction Gallstone diseases constitute a major part of patients visiting hospitals, and more than 50% of operation theaters are occupied by it or diseases related to it. It also imposes significant financial burden on health resources. The 21st century has opened with an improved foundation to our understanding of the basis of bile formation by defining the key transporters of the lipids in bile and the responsible genes. The specter of obesity as an epidemic in developed countries, and the recent recognition of the metabolic syndromes and their links to gallstone formation, emphasize the expectation of a rise in the frequency of cholesterol cholelithiasis. Materials and Methods Data pertaining to patients who were admitted/received surgery for a diagnosis of gallstone diseases at the Department of General Surgery of BPS GMC Khanpur Kalan was collected. The collected data was entered in a Microsoft Excel spreadsheet. Mean ± standard deviation (SD) was calculated for quantitative data, using Student’s “t” test/Kruskal test. Chi-square test was used to find out the association for categorical data. Results and Discussion Most of the patients were experiencing right hypochondriac pain (79.23%) as presenting complaints, with the most common age range being 31 to 40 years, followed by 41 to 50 years, that is, 31.85% and 20.74%, respectively. Females were most commonly affected, approximately 90%, and only 10% of patients with gallstones visiting our hospital were males. Maximum patients had chronic cholecystitis (80%) on histopathological examination, followed by cholesterosis (6.15%). As much as 82.6% of patients presented with mixed gallstones, followed by cholesterol stones, that is, 10.43%. All types of stones are more common in patients with abdominal adiposities, that is, having waist-to-hip ratio more than 0.85, and these findings are statistically significant. Conclusion Our study concluded that gallstones were more common in females of younger population (31–40 years) with right hypochondriac pain as presenting complaints. The most common histopathology was chronic cholecystitis with mixed types of stones, which is associated with increased waist-to-hip ratio. All biochemical markers were within normal range.Pushpendra MalikL.N.U. TarunSanjeet SinghMahinder K GargMukesh SangwanRahul KumarSebin SebastianThieme Medical and Scientific Publishers Pvt. Ltd.articlegallstone diseasesclinicopathological profilebiochemical profilecholecystitisOrthopedic surgeryRD701-811ENInternational Journal of Recent Surgical and Medical Sciences, Vol 7, Iss 02, Pp 72-76 (2021)
institution DOAJ
collection DOAJ
language EN
topic gallstone diseases
clinicopathological profile
biochemical profile
cholecystitis
Orthopedic surgery
RD701-811
spellingShingle gallstone diseases
clinicopathological profile
biochemical profile
cholecystitis
Orthopedic surgery
RD701-811
Pushpendra Malik
L.N.U. Tarun
Sanjeet Singh
Mahinder K Garg
Mukesh Sangwan
Rahul Kumar
Sebin Sebastian
A Prospective Observational Study of Clinicopathological and Biochemical Profile of Patients with Cholecystitis Visiting a Teaching Tertiary Care Centre of Haryana
description Introduction Gallstone diseases constitute a major part of patients visiting hospitals, and more than 50% of operation theaters are occupied by it or diseases related to it. It also imposes significant financial burden on health resources. The 21st century has opened with an improved foundation to our understanding of the basis of bile formation by defining the key transporters of the lipids in bile and the responsible genes. The specter of obesity as an epidemic in developed countries, and the recent recognition of the metabolic syndromes and their links to gallstone formation, emphasize the expectation of a rise in the frequency of cholesterol cholelithiasis. Materials and Methods Data pertaining to patients who were admitted/received surgery for a diagnosis of gallstone diseases at the Department of General Surgery of BPS GMC Khanpur Kalan was collected. The collected data was entered in a Microsoft Excel spreadsheet. Mean ± standard deviation (SD) was calculated for quantitative data, using Student’s “t” test/Kruskal test. Chi-square test was used to find out the association for categorical data. Results and Discussion Most of the patients were experiencing right hypochondriac pain (79.23%) as presenting complaints, with the most common age range being 31 to 40 years, followed by 41 to 50 years, that is, 31.85% and 20.74%, respectively. Females were most commonly affected, approximately 90%, and only 10% of patients with gallstones visiting our hospital were males. Maximum patients had chronic cholecystitis (80%) on histopathological examination, followed by cholesterosis (6.15%). As much as 82.6% of patients presented with mixed gallstones, followed by cholesterol stones, that is, 10.43%. All types of stones are more common in patients with abdominal adiposities, that is, having waist-to-hip ratio more than 0.85, and these findings are statistically significant. Conclusion Our study concluded that gallstones were more common in females of younger population (31–40 years) with right hypochondriac pain as presenting complaints. The most common histopathology was chronic cholecystitis with mixed types of stones, which is associated with increased waist-to-hip ratio. All biochemical markers were within normal range.
format article
author Pushpendra Malik
L.N.U. Tarun
Sanjeet Singh
Mahinder K Garg
Mukesh Sangwan
Rahul Kumar
Sebin Sebastian
author_facet Pushpendra Malik
L.N.U. Tarun
Sanjeet Singh
Mahinder K Garg
Mukesh Sangwan
Rahul Kumar
Sebin Sebastian
author_sort Pushpendra Malik
title A Prospective Observational Study of Clinicopathological and Biochemical Profile of Patients with Cholecystitis Visiting a Teaching Tertiary Care Centre of Haryana
title_short A Prospective Observational Study of Clinicopathological and Biochemical Profile of Patients with Cholecystitis Visiting a Teaching Tertiary Care Centre of Haryana
title_full A Prospective Observational Study of Clinicopathological and Biochemical Profile of Patients with Cholecystitis Visiting a Teaching Tertiary Care Centre of Haryana
title_fullStr A Prospective Observational Study of Clinicopathological and Biochemical Profile of Patients with Cholecystitis Visiting a Teaching Tertiary Care Centre of Haryana
title_full_unstemmed A Prospective Observational Study of Clinicopathological and Biochemical Profile of Patients with Cholecystitis Visiting a Teaching Tertiary Care Centre of Haryana
title_sort prospective observational study of clinicopathological and biochemical profile of patients with cholecystitis visiting a teaching tertiary care centre of haryana
publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate 2021
url https://doaj.org/article/ac590b7ca3424998bb97370e4d785ef3
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