Task-dependent effects of nicotine treatment on auditory performance in young-adult and elderly human nonsmokers

Abstract Electrophysiological studies show that nicotine enhances neural responses to characteristic frequency stimuli. Previous behavioral studies partially corroborate these findings in young adults, showing that nicotine selectively enhances auditory processing in difficult listening conditions....

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Autores principales:	Shuping Sun, Michelle R. Kapolowicz, Matthew Richardson, Raju Metherate, Fan-Gang Zeng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ac5a8cfedcaa4d55849df1153f8727f5
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spelling	oai:doaj.org-article:ac5a8cfedcaa4d55849df1153f8727f52021-12-02T18:02:44ZTask-dependent effects of nicotine treatment on auditory performance in young-adult and elderly human nonsmokers10.1038/s41598-021-92588-z2045-2322https://doaj.org/article/ac5a8cfedcaa4d55849df1153f8727f52021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92588-zhttps://doaj.org/toc/2045-2322Abstract Electrophysiological studies show that nicotine enhances neural responses to characteristic frequency stimuli. Previous behavioral studies partially corroborate these findings in young adults, showing that nicotine selectively enhances auditory processing in difficult listening conditions. The present work extended previous work to include both young and older adults and assessed the nicotine effect on sound frequency and intensity discrimination. Hypotheses were that nicotine improves auditory performance and that the degree of improvement is inversely proportional to baseline performance. Young (19–23 years old) normal-hearing nonsmokers and elderly (61–80) nonsmokers with normal hearing between 500 and 2000 Hz received nicotine gum (6 mg) or placebo gum in a single-blind, randomized crossover design. Participants performed three experiments (frequency discrimination, frequency modulation identification, and intensity discrimination) before and after treatment. The perceptual differences were analyzed between pre- and post-treatment, as well as between post-treatment nicotine and placebo conditions as a function of pre-treatment baseline performance. Compared to pre-treatment performance, nicotine significantly improved frequency discrimination. Compared to placebo, nicotine significantly improved performance for intensity discrimination, and the improvement was more pronounced in the elderly with lower baseline performance. Nicotine had no effect on frequency modulation identification. Nicotine effects are task-dependent, reflecting possible interplays of subjects, tasks and neural mechanisms.Shuping SunMichelle R. KapolowiczMatthew RichardsonRaju MetherateFan-Gang ZengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shuping Sun Michelle R. Kapolowicz Matthew Richardson Raju Metherate Fan-Gang Zeng Task-dependent effects of nicotine treatment on auditory performance in young-adult and elderly human nonsmokers
description	Abstract Electrophysiological studies show that nicotine enhances neural responses to characteristic frequency stimuli. Previous behavioral studies partially corroborate these findings in young adults, showing that nicotine selectively enhances auditory processing in difficult listening conditions. The present work extended previous work to include both young and older adults and assessed the nicotine effect on sound frequency and intensity discrimination. Hypotheses were that nicotine improves auditory performance and that the degree of improvement is inversely proportional to baseline performance. Young (19–23 years old) normal-hearing nonsmokers and elderly (61–80) nonsmokers with normal hearing between 500 and 2000 Hz received nicotine gum (6 mg) or placebo gum in a single-blind, randomized crossover design. Participants performed three experiments (frequency discrimination, frequency modulation identification, and intensity discrimination) before and after treatment. The perceptual differences were analyzed between pre- and post-treatment, as well as between post-treatment nicotine and placebo conditions as a function of pre-treatment baseline performance. Compared to pre-treatment performance, nicotine significantly improved frequency discrimination. Compared to placebo, nicotine significantly improved performance for intensity discrimination, and the improvement was more pronounced in the elderly with lower baseline performance. Nicotine had no effect on frequency modulation identification. Nicotine effects are task-dependent, reflecting possible interplays of subjects, tasks and neural mechanisms.
format	article
author	Shuping Sun Michelle R. Kapolowicz Matthew Richardson Raju Metherate Fan-Gang Zeng
author_facet	Shuping Sun Michelle R. Kapolowicz Matthew Richardson Raju Metherate Fan-Gang Zeng
author_sort	Shuping Sun
title	Task-dependent effects of nicotine treatment on auditory performance in young-adult and elderly human nonsmokers
title_short	Task-dependent effects of nicotine treatment on auditory performance in young-adult and elderly human nonsmokers
title_full	Task-dependent effects of nicotine treatment on auditory performance in young-adult and elderly human nonsmokers
title_fullStr	Task-dependent effects of nicotine treatment on auditory performance in young-adult and elderly human nonsmokers
title_full_unstemmed	Task-dependent effects of nicotine treatment on auditory performance in young-adult and elderly human nonsmokers
title_sort	task-dependent effects of nicotine treatment on auditory performance in young-adult and elderly human nonsmokers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ac5a8cfedcaa4d55849df1153f8727f5
work_keys_str_mv	AT shupingsun taskdependenteffectsofnicotinetreatmentonauditoryperformanceinyoungadultandelderlyhumannonsmokers AT michellerkapolowicz taskdependenteffectsofnicotinetreatmentonauditoryperformanceinyoungadultandelderlyhumannonsmokers AT matthewrichardson taskdependenteffectsofnicotinetreatmentonauditoryperformanceinyoungadultandelderlyhumannonsmokers AT rajumetherate taskdependenteffectsofnicotinetreatmentonauditoryperformanceinyoungadultandelderlyhumannonsmokers AT fangangzeng taskdependenteffectsofnicotinetreatmentonauditoryperformanceinyoungadultandelderlyhumannonsmokers
_version_	1718378889120579584

Task-dependent effects of nicotine treatment on auditory performance in young-adult and elderly human nonsmokers

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