Inverse association between serum bilirubin level and testosterone deficiency in middle-aged and older men

Abstract Low serum bilirubin levels have been associated with increased risk of cardiovascular disease (CVD) and metabolic syndrome. Testosterone deficiency could also contribute to increased risk of CVD and metabolic syndrome. Therefore, this study aimed to examine the relationship between serum bi...

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Autores principales:	Hye-Min Park, Haeyoung Kim, Hye Sun Lee, Yong-Jae Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ac5afa469aa4456c8031ddbb0e3482c5
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spelling	oai:doaj.org-article:ac5afa469aa4456c8031ddbb0e3482c52021-12-02T14:27:53ZInverse association between serum bilirubin level and testosterone deficiency in middle-aged and older men10.1038/s41598-021-87220-z2045-2322https://doaj.org/article/ac5afa469aa4456c8031ddbb0e3482c52021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87220-zhttps://doaj.org/toc/2045-2322Abstract Low serum bilirubin levels have been associated with increased risk of cardiovascular disease (CVD) and metabolic syndrome. Testosterone deficiency could also contribute to increased risk of CVD and metabolic syndrome. Therefore, this study aimed to examine the relationship between serum bilirubin level and testosterone deficiency in 1284 Korean men aged 45 to 70 years. Serum bilirubin level was categorized into quartiles: Q1 ≤ 0.7, Q2 0.8–0.9, Q3 1.0–1.1, and Q4 ≥ 1.2 mg/dL. Testosterone deficiency was defined as level less than 8.0 nmol/L, as suggested by the position statement of International Society of Andrology. The overall prevalence of testosterone deficiency was 5.8% and significantly decreased with the quartiles from Q1 to Q4. Compared with the referent fourth quartile (serum bilirubin ≥ 1.2 mg/dL), the ORs (95% CIs) for testosterone deficiency was 2.29 (1.04–4.94) for the first quartile after adjusting for age, fasting glucose, triglyceride, HDL-cholesterol, leukocyte count, hemoglobin, smoking status, and alcohol intake. We found inversely graded associations of serum bilirubin level with testosterone deficiency. These findings suggest that low bilirubin level may be interpreted as a state of testosterone deficiency in middle-aged and older men.Hye-Min ParkHaeyoung KimHye Sun LeeYong-Jae LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hye-Min Park Haeyoung Kim Hye Sun Lee Yong-Jae Lee Inverse association between serum bilirubin level and testosterone deficiency in middle-aged and older men
description	Abstract Low serum bilirubin levels have been associated with increased risk of cardiovascular disease (CVD) and metabolic syndrome. Testosterone deficiency could also contribute to increased risk of CVD and metabolic syndrome. Therefore, this study aimed to examine the relationship between serum bilirubin level and testosterone deficiency in 1284 Korean men aged 45 to 70 years. Serum bilirubin level was categorized into quartiles: Q1 ≤ 0.7, Q2 0.8–0.9, Q3 1.0–1.1, and Q4 ≥ 1.2 mg/dL. Testosterone deficiency was defined as level less than 8.0 nmol/L, as suggested by the position statement of International Society of Andrology. The overall prevalence of testosterone deficiency was 5.8% and significantly decreased with the quartiles from Q1 to Q4. Compared with the referent fourth quartile (serum bilirubin ≥ 1.2 mg/dL), the ORs (95% CIs) for testosterone deficiency was 2.29 (1.04–4.94) for the first quartile after adjusting for age, fasting glucose, triglyceride, HDL-cholesterol, leukocyte count, hemoglobin, smoking status, and alcohol intake. We found inversely graded associations of serum bilirubin level with testosterone deficiency. These findings suggest that low bilirubin level may be interpreted as a state of testosterone deficiency in middle-aged and older men.
format	article
author	Hye-Min Park Haeyoung Kim Hye Sun Lee Yong-Jae Lee
author_facet	Hye-Min Park Haeyoung Kim Hye Sun Lee Yong-Jae Lee
author_sort	Hye-Min Park
title	Inverse association between serum bilirubin level and testosterone deficiency in middle-aged and older men
title_short	Inverse association between serum bilirubin level and testosterone deficiency in middle-aged and older men
title_full	Inverse association between serum bilirubin level and testosterone deficiency in middle-aged and older men
title_fullStr	Inverse association between serum bilirubin level and testosterone deficiency in middle-aged and older men
title_full_unstemmed	Inverse association between serum bilirubin level and testosterone deficiency in middle-aged and older men
title_sort	inverse association between serum bilirubin level and testosterone deficiency in middle-aged and older men
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ac5afa469aa4456c8031ddbb0e3482c5
work_keys_str_mv	AT hyeminpark inverseassociationbetweenserumbilirubinlevelandtestosteronedeficiencyinmiddleagedandoldermen AT haeyoungkim inverseassociationbetweenserumbilirubinlevelandtestosteronedeficiencyinmiddleagedandoldermen AT hyesunlee inverseassociationbetweenserumbilirubinlevelandtestosteronedeficiencyinmiddleagedandoldermen AT yongjaelee inverseassociationbetweenserumbilirubinlevelandtestosteronedeficiencyinmiddleagedandoldermen
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Inverse association between serum bilirubin level and testosterone deficiency in middle-aged and older men

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