Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions

Myoepithelial carcinoma (MECA) is a rare aggressive salivary gland cancer. Here, the authors analyze the genomic landscape of MECA and identify a high prevalence of oncogenic gene fusions, primarily PLAG1 fusions, highlighting TGFBR3-PLAG1 as a potential hallmark of MECA.

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Autores principales:	Martin G. Dalin, Nora Katabi, Marta Persson, Ken-Wing Lee, Vladimir Makarov, Alexis Desrichard, Logan A. Walsh, Lyndsay West, Zaineb Nadeem, Deepa Ramaswami, Jonathan J. Havel, Fengshen Kuo, Kalyani Chadalavada, Gouri J. Nanjangud, Ian Ganly, Nadeem Riaz, Alan L. Ho, Cristina R. Antonescu, Ronald Ghossein, Göran Stenman, Timothy A. Chan, Luc G. T. Morris
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ac5cf5be332f48df922f9b4c8c1e098f
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spelling	oai:doaj.org-article:ac5cf5be332f48df922f9b4c8c1e098f2021-12-02T14:42:01ZMulti-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions10.1038/s41467-017-01178-z2041-1723https://doaj.org/article/ac5cf5be332f48df922f9b4c8c1e098f2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01178-zhttps://doaj.org/toc/2041-1723Myoepithelial carcinoma (MECA) is a rare aggressive salivary gland cancer. Here, the authors analyze the genomic landscape of MECA and identify a high prevalence of oncogenic gene fusions, primarily PLAG1 fusions, highlighting TGFBR3-PLAG1 as a potential hallmark of MECA.Martin G. DalinNora KatabiMarta PerssonKen-Wing LeeVladimir MakarovAlexis DesrichardLogan A. WalshLyndsay WestZaineb NadeemDeepa RamaswamiJonathan J. HavelFengshen KuoKalyani ChadalavadaGouri J. NanjangudIan GanlyNadeem RiazAlan L. HoCristina R. AntonescuRonald GhosseinGöran StenmanTimothy A. ChanLuc G. T. MorrisNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin G. Dalin Nora Katabi Marta Persson Ken-Wing Lee Vladimir Makarov Alexis Desrichard Logan A. Walsh Lyndsay West Zaineb Nadeem Deepa Ramaswami Jonathan J. Havel Fengshen Kuo Kalyani Chadalavada Gouri J. Nanjangud Ian Ganly Nadeem Riaz Alan L. Ho Cristina R. Antonescu Ronald Ghossein Göran Stenman Timothy A. Chan Luc G. T. Morris Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions
description	Myoepithelial carcinoma (MECA) is a rare aggressive salivary gland cancer. Here, the authors analyze the genomic landscape of MECA and identify a high prevalence of oncogenic gene fusions, primarily PLAG1 fusions, highlighting TGFBR3-PLAG1 as a potential hallmark of MECA.
format	article
author	Martin G. Dalin Nora Katabi Marta Persson Ken-Wing Lee Vladimir Makarov Alexis Desrichard Logan A. Walsh Lyndsay West Zaineb Nadeem Deepa Ramaswami Jonathan J. Havel Fengshen Kuo Kalyani Chadalavada Gouri J. Nanjangud Ian Ganly Nadeem Riaz Alan L. Ho Cristina R. Antonescu Ronald Ghossein Göran Stenman Timothy A. Chan Luc G. T. Morris
author_facet	Martin G. Dalin Nora Katabi Marta Persson Ken-Wing Lee Vladimir Makarov Alexis Desrichard Logan A. Walsh Lyndsay West Zaineb Nadeem Deepa Ramaswami Jonathan J. Havel Fengshen Kuo Kalyani Chadalavada Gouri J. Nanjangud Ian Ganly Nadeem Riaz Alan L. Ho Cristina R. Antonescu Ronald Ghossein Göran Stenman Timothy A. Chan Luc G. T. Morris
author_sort	Martin G. Dalin
title	Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions
title_short	Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions
title_full	Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions
title_fullStr	Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions
title_full_unstemmed	Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions
title_sort	multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ac5cf5be332f48df922f9b4c8c1e098f
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Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions

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