Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions
Myoepithelial carcinoma (MECA) is a rare aggressive salivary gland cancer. Here, the authors analyze the genomic landscape of MECA and identify a high prevalence of oncogenic gene fusions, primarily PLAG1 fusions, highlighting TGFBR3-PLAG1 as a potential hallmark of MECA.
Saved in:
Main Authors: | Martin G. Dalin, Nora Katabi, Marta Persson, Ken-Wing Lee, Vladimir Makarov, Alexis Desrichard, Logan A. Walsh, Lyndsay West, Zaineb Nadeem, Deepa Ramaswami, Jonathan J. Havel, Fengshen Kuo, Kalyani Chadalavada, Gouri J. Nanjangud, Ian Ganly, Nadeem Riaz, Alan L. Ho, Cristina R. Antonescu, Ronald Ghossein, Göran Stenman, Timothy A. Chan, Luc G. T. Morris |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2017
|
Subjects: | |
Online Access: | https://doaj.org/article/ac5cf5be332f48df922f9b4c8c1e098f |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Expression of LGR5 in mammary myoepithelial cells and in triple-negative breast cancers
by: Hyun Ju Lee, et al.
Published: (2021) -
Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ
by: Lina Ding, et al.
Published: (2019) -
Epithelial-Myoepithelial Carcinoma of the Minor Salivary Glands: Case Series with Comprehensive Review
by: Kohei Okuyama, et al.
Published: (2021) -
Derivation of myoepithelial progenitor cells from bipotent mammary stem/progenitor cells.
by: Xiangshan Zhao, et al.
Published: (2012) -
Myoepithelial Carcinoma Spindle cell type, Clear cell type, and Plasmacytoid type: Serial Kasus A Case Series of Myoepithelial Carcinoma Spindle cell type, Clear cell type, and Plasmacytoid type
by: Dian Yuliartha Lestari, et al.
Published: (2018)