Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise

Heavy-load eccentric exercise causes an increase in cytoplasmic Ca2+ that can damage muscles. Here the authors show that the t-tubule system remodels into vacuoles that can sequester calcium from the cytoplasm and are not responsive to store-operated Ca2+ entry, thereby potentially protecting muscle...

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Autores principales:	Tanya R. Cully, Robyn M. Murphy, Llion Roberts, Truls Raastad, Robert G. Fassett, Jeff S. Coombes, Isuru D. Jayasinghe, Bradley S. Launikonis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ac5dc5c88c904369b9a94eb7648f2c36
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spelling	oai:doaj.org-article:ac5dc5c88c904369b9a94eb7648f2c362021-12-02T14:42:39ZHuman skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise10.1038/ncomms142662041-1723https://doaj.org/article/ac5dc5c88c904369b9a94eb7648f2c362017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14266https://doaj.org/toc/2041-1723Heavy-load eccentric exercise causes an increase in cytoplasmic Ca2+ that can damage muscles. Here the authors show that the t-tubule system remodels into vacuoles that can sequester calcium from the cytoplasm and are not responsive to store-operated Ca2+ entry, thereby potentially protecting muscles against elevated [Ca2+].Tanya R. CullyRobyn M. MurphyLlion RobertsTruls RaastadRobert G. FassettJeff S. CoombesIsuru D. JayasingheBradley S. LaunikonisNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tanya R. Cully Robyn M. Murphy Llion Roberts Truls Raastad Robert G. Fassett Jeff S. Coombes Isuru D. Jayasinghe Bradley S. Launikonis Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise
description	Heavy-load eccentric exercise causes an increase in cytoplasmic Ca2+ that can damage muscles. Here the authors show that the t-tubule system remodels into vacuoles that can sequester calcium from the cytoplasm and are not responsive to store-operated Ca2+ entry, thereby potentially protecting muscles against elevated [Ca2+].
format	article
author	Tanya R. Cully Robyn M. Murphy Llion Roberts Truls Raastad Robert G. Fassett Jeff S. Coombes Isuru D. Jayasinghe Bradley S. Launikonis
author_facet	Tanya R. Cully Robyn M. Murphy Llion Roberts Truls Raastad Robert G. Fassett Jeff S. Coombes Isuru D. Jayasinghe Bradley S. Launikonis
author_sort	Tanya R. Cully
title	Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise
title_short	Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise
title_full	Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise
title_fullStr	Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise
title_full_unstemmed	Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise
title_sort	human skeletal muscle plasmalemma alters its structure to change its ca2+-handling following heavy-load resistance exercise
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ac5dc5c88c904369b9a94eb7648f2c36
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Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise

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