Reviewing cancer’s biology: an eclectic approach

Abstract Background Cancer refers to a group of some of the worldwide most diagnosed and deadliest pathophysiological conditions that conquered researchers’ attention for decades and yet begs for more questions for a full comprehension of its complex cellular and molecular pathology. Main body The d...

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Autores principales:	Ibrahim Diori Karidio, Senay Hamarat Sanlier
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Lonal evolution model Cancer stem cell Cancer stem cell plasticity Epithelial-mesenchymal transition (EMT) Cancer epigenetics Microbiota Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/ac62069bbfac42a1bd1f257bdf7e2a8d
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spelling	oai:doaj.org-article:ac62069bbfac42a1bd1f257bdf7e2a8d2021-11-07T12:12:04ZReviewing cancer’s biology: an eclectic approach10.1186/s43046-021-00088-y2589-0409https://doaj.org/article/ac62069bbfac42a1bd1f257bdf7e2a8d2021-11-01T00:00:00Zhttps://doi.org/10.1186/s43046-021-00088-yhttps://doaj.org/toc/2589-0409Abstract Background Cancer refers to a group of some of the worldwide most diagnosed and deadliest pathophysiological conditions that conquered researchers’ attention for decades and yet begs for more questions for a full comprehension of its complex cellular and molecular pathology. Main body The disease conditions are commonly characterized by unrestricted cell proliferation and dysfunctional replicative senescence pathways. In fact, the cell cycle operates under the rigorous control of complex signaling pathways involving cyclins and cyclin-dependent kinases assumed to be specific to each phase of the cycle. At each of these checkpoints, the cell is checked essentially for its DNA integrity. Genetic defects observed in these molecules (i.e., cyclins, cyclin-dependent kinases) are common features of cancer cells. Nevertheless, each cancer is different concerning its molecular and cellular etiology. These could range from the genetic defects mechanisms and/or the environmental conditions favoring epigenetically harbored homeostasis driving tumorigenesis alongside with the intratumoral heterogeneity with respect to the model that the tumor follows. Conclusions This review is not meant to be an exhaustive interpretation of carcinogenesis but to summarize some basic features of the molecular etiology of cancer and the intratumoral heterogeneity models that eventually bolster anticancer drug resistance for a more efficient design of drug targeting the pitfalls of the models.Ibrahim Diori KaridioSenay Hamarat SanlierSpringerOpenarticleLonal evolution modelCancer stem cellCancer stem cell plasticityEpithelial-mesenchymal transition (EMT)Cancer epigeneticsMicrobiotaNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENJournal of the Egyptian National Cancer Institute, Vol 33, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lonal evolution model Cancer stem cell Cancer stem cell plasticity Epithelial-mesenchymal transition (EMT) Cancer epigenetics Microbiota Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Lonal evolution model Cancer stem cell Cancer stem cell plasticity Epithelial-mesenchymal transition (EMT) Cancer epigenetics Microbiota Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ibrahim Diori Karidio Senay Hamarat Sanlier Reviewing cancer’s biology: an eclectic approach
description	Abstract Background Cancer refers to a group of some of the worldwide most diagnosed and deadliest pathophysiological conditions that conquered researchers’ attention for decades and yet begs for more questions for a full comprehension of its complex cellular and molecular pathology. Main body The disease conditions are commonly characterized by unrestricted cell proliferation and dysfunctional replicative senescence pathways. In fact, the cell cycle operates under the rigorous control of complex signaling pathways involving cyclins and cyclin-dependent kinases assumed to be specific to each phase of the cycle. At each of these checkpoints, the cell is checked essentially for its DNA integrity. Genetic defects observed in these molecules (i.e., cyclins, cyclin-dependent kinases) are common features of cancer cells. Nevertheless, each cancer is different concerning its molecular and cellular etiology. These could range from the genetic defects mechanisms and/or the environmental conditions favoring epigenetically harbored homeostasis driving tumorigenesis alongside with the intratumoral heterogeneity with respect to the model that the tumor follows. Conclusions This review is not meant to be an exhaustive interpretation of carcinogenesis but to summarize some basic features of the molecular etiology of cancer and the intratumoral heterogeneity models that eventually bolster anticancer drug resistance for a more efficient design of drug targeting the pitfalls of the models.
format	article
author	Ibrahim Diori Karidio Senay Hamarat Sanlier
author_facet	Ibrahim Diori Karidio Senay Hamarat Sanlier
author_sort	Ibrahim Diori Karidio
title	Reviewing cancer’s biology: an eclectic approach
title_short	Reviewing cancer’s biology: an eclectic approach
title_full	Reviewing cancer’s biology: an eclectic approach
title_fullStr	Reviewing cancer’s biology: an eclectic approach
title_full_unstemmed	Reviewing cancer’s biology: an eclectic approach
title_sort	reviewing cancer’s biology: an eclectic approach
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/ac62069bbfac42a1bd1f257bdf7e2a8d
work_keys_str_mv	AT ibrahimdiorikaridio reviewingcancersbiologyaneclecticapproach AT senayhamaratsanlier reviewingcancersbiologyaneclecticapproach
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Reviewing cancer’s biology: an eclectic approach

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