An Update on the Molecular Pathology of Metaplastic Breast Cancer

Amy E McCart Reed,1 Emarene M Kalaw,1 Sunil R Lakhani1,2 1UQ Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia; 2Pathology Queensland, Brisbane, Queensland, AustraliaCorrespondence: Sunil R Lakhani Email s.lakhani@uq.edu.auAbstract: Metaplastic breast cancer...

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Autores principales:	McCart Reed AE, Kalaw EM, Lakhani SR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	metaplastic triple negative-breast cancer precision oncology Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/ac6549a58d8e4fce80894fa9f6c0c0f9
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spelling	oai:doaj.org-article:ac6549a58d8e4fce80894fa9f6c0c0f92021-12-02T14:29:46ZAn Update on the Molecular Pathology of Metaplastic Breast Cancer1179-1314https://doaj.org/article/ac6549a58d8e4fce80894fa9f6c0c0f92021-02-01T00:00:00Zhttps://www.dovepress.com/an-update-on-the-molecular-pathology-of-metaplastic-breast-cancer-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Amy E McCart Reed,1 Emarene M Kalaw,1 Sunil R Lakhani1,2 1UQ Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia; 2Pathology Queensland, Brisbane, Queensland, AustraliaCorrespondence: Sunil R Lakhani Email s.lakhani@uq.edu.auAbstract: Metaplastic breast cancer (MpBC) is a fascinating morphologic sub-type of breast cancer, characterised by intra-tumoural heterogeneity. By definition, these tumors show regions of metaplasia that can present as spindle, squamous, chondroid or even osseous differentiation. MpBC are typically triple-negative, and are therefore not targetable with hormone therapy or anti-HER2 therapies, leaving only chemotherapeutics for management. MpBC are known for their aggressive course and poor response to chemotherapy. We review herein the pathology and molecular landscape of MpBC and discuss opportunities for targetted therapies as well as immunotherapies.Keywords: metaplastic, triple-negative breast cancer, precision oncologyMcCart Reed AEKalaw EMLakhani SRDove Medical Pressarticlemetaplastictriple negative-breast cancerprecision oncologyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 13, Pp 161-170 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metaplastic triple negative-breast cancer precision oncology Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	metaplastic triple negative-breast cancer precision oncology Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 McCart Reed AE Kalaw EM Lakhani SR An Update on the Molecular Pathology of Metaplastic Breast Cancer
description	Amy E McCart Reed,1 Emarene M Kalaw,1 Sunil R Lakhani1,2 1UQ Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia; 2Pathology Queensland, Brisbane, Queensland, AustraliaCorrespondence: Sunil R Lakhani Email s.lakhani@uq.edu.auAbstract: Metaplastic breast cancer (MpBC) is a fascinating morphologic sub-type of breast cancer, characterised by intra-tumoural heterogeneity. By definition, these tumors show regions of metaplasia that can present as spindle, squamous, chondroid or even osseous differentiation. MpBC are typically triple-negative, and are therefore not targetable with hormone therapy or anti-HER2 therapies, leaving only chemotherapeutics for management. MpBC are known for their aggressive course and poor response to chemotherapy. We review herein the pathology and molecular landscape of MpBC and discuss opportunities for targetted therapies as well as immunotherapies.Keywords: metaplastic, triple-negative breast cancer, precision oncology
format	article
author	McCart Reed AE Kalaw EM Lakhani SR
author_facet	McCart Reed AE Kalaw EM Lakhani SR
author_sort	McCart Reed AE
title	An Update on the Molecular Pathology of Metaplastic Breast Cancer
title_short	An Update on the Molecular Pathology of Metaplastic Breast Cancer
title_full	An Update on the Molecular Pathology of Metaplastic Breast Cancer
title_fullStr	An Update on the Molecular Pathology of Metaplastic Breast Cancer
title_full_unstemmed	An Update on the Molecular Pathology of Metaplastic Breast Cancer
title_sort	update on the molecular pathology of metaplastic breast cancer
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/ac6549a58d8e4fce80894fa9f6c0c0f9
work_keys_str_mv	AT mccartreedae anupdateonthemolecularpathologyofmetaplasticbreastcancer AT kalawem anupdateonthemolecularpathologyofmetaplasticbreastcancer AT lakhanisr anupdateonthemolecularpathologyofmetaplasticbreastcancer AT mccartreedae updateonthemolecularpathologyofmetaplasticbreastcancer AT kalawem updateonthemolecularpathologyofmetaplasticbreastcancer AT lakhanisr updateonthemolecularpathologyofmetaplasticbreastcancer
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An Update on the Molecular Pathology of Metaplastic Breast Cancer

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