The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex

The innate immune receptor NOD2 is tightly regulated to ensure beneficial antimicrobial immunity. Here the authors show that the H2A deubiquitinase MYSM1 restrains NOD2 signaling by removing lysine 63 (K63), K27, M1 but not K48 polyubiquitin chains from its downstream adaptor protein RIP2.

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Autores principales:	Swarupa Panda, Nelson O. Gekara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ac65e72c5f21407fa3aa2c108611f533
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spelling	oai:doaj.org-article:ac65e72c5f21407fa3aa2c108611f5332021-12-02T15:34:00ZThe deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex10.1038/s41467-018-07016-02041-1723https://doaj.org/article/ac65e72c5f21407fa3aa2c108611f5332018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07016-0https://doaj.org/toc/2041-1723The innate immune receptor NOD2 is tightly regulated to ensure beneficial antimicrobial immunity. Here the authors show that the H2A deubiquitinase MYSM1 restrains NOD2 signaling by removing lysine 63 (K63), K27, M1 but not K48 polyubiquitin chains from its downstream adaptor protein RIP2.Swarupa PandaNelson O. GekaraNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Swarupa Panda Nelson O. Gekara The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex
description	The innate immune receptor NOD2 is tightly regulated to ensure beneficial antimicrobial immunity. Here the authors show that the H2A deubiquitinase MYSM1 restrains NOD2 signaling by removing lysine 63 (K63), K27, M1 but not K48 polyubiquitin chains from its downstream adaptor protein RIP2.
format	article
author	Swarupa Panda Nelson O. Gekara
author_facet	Swarupa Panda Nelson O. Gekara
author_sort	Swarupa Panda
title	The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex
title_short	The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex
title_full	The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex
title_fullStr	The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex
title_full_unstemmed	The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex
title_sort	deubiquitinase mysm1 dampens nod2-mediated inflammation and tissue damage by inactivating the rip2 complex
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ac65e72c5f21407fa3aa2c108611f533
work_keys_str_mv	AT swarupapanda thedeubiquitinasemysm1dampensnod2mediatedinflammationandtissuedamagebyinactivatingtherip2complex AT nelsonogekara thedeubiquitinasemysm1dampensnod2mediatedinflammationandtissuedamagebyinactivatingtherip2complex AT swarupapanda deubiquitinasemysm1dampensnod2mediatedinflammationandtissuedamagebyinactivatingtherip2complex AT nelsonogekara deubiquitinasemysm1dampensnod2mediatedinflammationandtissuedamagebyinactivatingtherip2complex
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The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex

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