Elucidating the role of metal ions in carbonic anhydrase catalysis

Metalloenzymes often show different catalytic activities in the presence of non-native metal ions. Here, the authors report structures of carbonic anhydrase bound to zinc and several other metal ions and demonstrate that metal ion coordination geometries directly impact catalytic activity of the enz...

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Auteurs principaux:	Jin Kyun Kim, Cheol Lee, Seon Woo Lim, Aniruddha Adhikari, Jacob T. Andring, Robert McKenna, Cheol-Min Ghim, Chae Un Kim
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/ac6771c63a524fde9f72e8f71131a4d1
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spelling	oai:doaj.org-article:ac6771c63a524fde9f72e8f71131a4d12021-12-02T17:41:08ZElucidating the role of metal ions in carbonic anhydrase catalysis10.1038/s41467-020-18425-52041-1723https://doaj.org/article/ac6771c63a524fde9f72e8f71131a4d12020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18425-5https://doaj.org/toc/2041-1723Metalloenzymes often show different catalytic activities in the presence of non-native metal ions. Here, the authors report structures of carbonic anhydrase bound to zinc and several other metal ions and demonstrate that metal ion coordination geometries directly impact catalytic activity of the enzyme.Jin Kyun KimCheol LeeSeon Woo LimAniruddha AdhikariJacob T. AndringRobert McKennaCheol-Min GhimChae Un KimNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jin Kyun Kim Cheol Lee Seon Woo Lim Aniruddha Adhikari Jacob T. Andring Robert McKenna Cheol-Min Ghim Chae Un Kim Elucidating the role of metal ions in carbonic anhydrase catalysis
description	Metalloenzymes often show different catalytic activities in the presence of non-native metal ions. Here, the authors report structures of carbonic anhydrase bound to zinc and several other metal ions and demonstrate that metal ion coordination geometries directly impact catalytic activity of the enzyme.
format	article
author	Jin Kyun Kim Cheol Lee Seon Woo Lim Aniruddha Adhikari Jacob T. Andring Robert McKenna Cheol-Min Ghim Chae Un Kim
author_facet	Jin Kyun Kim Cheol Lee Seon Woo Lim Aniruddha Adhikari Jacob T. Andring Robert McKenna Cheol-Min Ghim Chae Un Kim
author_sort	Jin Kyun Kim
title	Elucidating the role of metal ions in carbonic anhydrase catalysis
title_short	Elucidating the role of metal ions in carbonic anhydrase catalysis
title_full	Elucidating the role of metal ions in carbonic anhydrase catalysis
title_fullStr	Elucidating the role of metal ions in carbonic anhydrase catalysis
title_full_unstemmed	Elucidating the role of metal ions in carbonic anhydrase catalysis
title_sort	elucidating the role of metal ions in carbonic anhydrase catalysis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ac6771c63a524fde9f72e8f71131a4d1
work_keys_str_mv	AT jinkyunkim elucidatingtheroleofmetalionsincarbonicanhydrasecatalysis AT cheollee elucidatingtheroleofmetalionsincarbonicanhydrasecatalysis AT seonwoolim elucidatingtheroleofmetalionsincarbonicanhydrasecatalysis AT aniruddhaadhikari elucidatingtheroleofmetalionsincarbonicanhydrasecatalysis AT jacobtandring elucidatingtheroleofmetalionsincarbonicanhydrasecatalysis AT robertmckenna elucidatingtheroleofmetalionsincarbonicanhydrasecatalysis AT cheolminghim elucidatingtheroleofmetalionsincarbonicanhydrasecatalysis AT chaeunkim elucidatingtheroleofmetalionsincarbonicanhydrasecatalysis
_version_	1718379723851038720

Elucidating the role of metal ions in carbonic anhydrase catalysis

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