Elucidating the role of metal ions in carbonic anhydrase catalysis
Metalloenzymes often show different catalytic activities in the presence of non-native metal ions. Here, the authors report structures of carbonic anhydrase bound to zinc and several other metal ions and demonstrate that metal ion coordination geometries directly impact catalytic activity of the enz...
Enregistré dans:
Auteurs principaux: | Jin Kyun Kim, Cheol Lee, Seon Woo Lim, Aniruddha Adhikari, Jacob T. Andring, Robert McKenna, Cheol-Min Ghim, Chae Un Kim |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2020
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/ac6771c63a524fde9f72e8f71131a4d1 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Backward simulation for inferring hidden biomolecular kinetic profiles
par: Junghun Chae, et autres
Publié: (2021) -
Dynamic coordination of two-metal-ions orchestrates λ-exonuclease catalysis
par: Wonseok Hwang, et autres
Publié: (2018) -
Human kidney organoids model the tacrolimus nephrotoxicity and elucidate the role of autophagy
par: Jin Won Kim, et autres
Publié: (2021) -
Programmable site-selective labeling of oligonucleotides based on carbene catalysis
par: Yang-Ha Lee, et autres
Publié: (2021) -
Bridging the gap between transition metal- and bio-catalysis via aqueous micellar catalysis
par: Margery Cortes-Clerget, et autres
Publié: (2019)