Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study

<b>Background:</b> The aim of this study was to analyze the percentage of patients admitted to the ICU having received the vaccine against COVID-19, to describe the clinical profile of vaccinated patients admitted to the ICU, and to assess the humoral immune response to vaccination. <...

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Autores principales:	Ángel Estella, Mª Luisa Cantón, Laura Muñoz, Isabel Rodriguez Higueras, María Recuerda Núñez, Julia Tejero Aranguren, Benito Zaya, Carmen Gómez, Rosario Amaya, Ángela Hurtado Martinez, María del Valle Odero Bernal, Carmen De la Fuente, Juan Carlos Alados, Jose Garnacho-Montero, on behalf of the Group of Infectious Diseases of the Andalusian Society of Intensive Care and Coronary Units SAMIUC
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SARS-CoV-2 severe pneumonia acute respiratory distress syndrome vaccine ICU Delta variant SARS-CoV-2 Medicine R
Acceso en línea:	https://doaj.org/article/ac691f79160c4104a33718551dc8708e
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spelling	oai:doaj.org-article:ac691f79160c4104a33718551dc8708e2021-11-25T18:07:01ZVaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study10.3390/jpm111110862075-4426https://doaj.org/article/ac691f79160c4104a33718551dc8708e2021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1086https://doaj.org/toc/2075-4426<b>Background:</b> The aim of this study was to analyze the percentage of patients admitted to the ICU having received the vaccine against COVID-19, to describe the clinical profile of vaccinated patients admitted to the ICU, and to assess the humoral immune response to vaccination. <b>Methods:</b> In this multicenter prospective descriptive cohort study, consecutive critically ill patients with confirmed SARS-CoV-2 pneumonia who received at least one dose of the SARS-CoV-2 vaccine were included. The time of study was from 1 July to 10 August of 2021. <b>Results:</b> Of the 94 consecutive patients from seven Andalusian ICUs admitted during the time of study, 50 (53.2%) received at least one dose of anti SARS-CoV-2 vaccine. No patient was admitted having previously had SARS-CoV-2 infection. The B.1.617.2 (Delta) variant was the most frequently identified, in 80.76% of cases. Patients with a complete vaccination with non-optimal antibody levels were immunocompromised. Fifteen patients were admitted to the ICU with Acute Respiratory Distress Syndrome (ARDS) without having completed their vaccination; the clinical profile was younger and with less comorbidities compared to patients with full vaccination. There were no differences in severity of ARDS. <b>Conclusions:</b> Most of the patients who were admitted to the ICU having received a dose of the vaccine were not optimally vaccinated; fully vaccinated patients who did not obtain optimal serum antibody levels were patients considered immunocompromised.Ángel EstellaMª Luisa CantónLaura MuñozIsabel Rodriguez HiguerasMaría Recuerda NúñezJulia Tejero ArangurenBenito ZayaCarmen GómezRosario AmayaÁngela Hurtado MartinezMaría del Valle Odero BernalCarmen De la FuenteJuan Carlos AladosJose Garnacho-Monteroon behalf of the Group of Infectious Diseases of the Andalusian Society of Intensive Care and Coronary Units SAMIUCMDPI AGarticleSARS-CoV-2severe pneumoniaacute respiratory distress syndromevaccineICUDelta variant SARS-CoV-2MedicineRENJournal of Personalized Medicine, Vol 11, Iss 1086, p 1086 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 severe pneumonia acute respiratory distress syndrome vaccine ICU Delta variant SARS-CoV-2 Medicine R
spellingShingle	SARS-CoV-2 severe pneumonia acute respiratory distress syndrome vaccine ICU Delta variant SARS-CoV-2 Medicine R Ángel Estella Mª Luisa Cantón Laura Muñoz Isabel Rodriguez Higueras María Recuerda Núñez Julia Tejero Aranguren Benito Zaya Carmen Gómez Rosario Amaya Ángela Hurtado Martinez María del Valle Odero Bernal Carmen De la Fuente Juan Carlos Alados Jose Garnacho-Montero on behalf of the Group of Infectious Diseases of the Andalusian Society of Intensive Care and Coronary Units SAMIUC Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study
description	<b>Background:</b> The aim of this study was to analyze the percentage of patients admitted to the ICU having received the vaccine against COVID-19, to describe the clinical profile of vaccinated patients admitted to the ICU, and to assess the humoral immune response to vaccination. <b>Methods:</b> In this multicenter prospective descriptive cohort study, consecutive critically ill patients with confirmed SARS-CoV-2 pneumonia who received at least one dose of the SARS-CoV-2 vaccine were included. The time of study was from 1 July to 10 August of 2021. <b>Results:</b> Of the 94 consecutive patients from seven Andalusian ICUs admitted during the time of study, 50 (53.2%) received at least one dose of anti SARS-CoV-2 vaccine. No patient was admitted having previously had SARS-CoV-2 infection. The B.1.617.2 (Delta) variant was the most frequently identified, in 80.76% of cases. Patients with a complete vaccination with non-optimal antibody levels were immunocompromised. Fifteen patients were admitted to the ICU with Acute Respiratory Distress Syndrome (ARDS) without having completed their vaccination; the clinical profile was younger and with less comorbidities compared to patients with full vaccination. There were no differences in severity of ARDS. <b>Conclusions:</b> Most of the patients who were admitted to the ICU having received a dose of the vaccine were not optimally vaccinated; fully vaccinated patients who did not obtain optimal serum antibody levels were patients considered immunocompromised.
format	article
author	Ángel Estella Mª Luisa Cantón Laura Muñoz Isabel Rodriguez Higueras María Recuerda Núñez Julia Tejero Aranguren Benito Zaya Carmen Gómez Rosario Amaya Ángela Hurtado Martinez María del Valle Odero Bernal Carmen De la Fuente Juan Carlos Alados Jose Garnacho-Montero on behalf of the Group of Infectious Diseases of the Andalusian Society of Intensive Care and Coronary Units SAMIUC
author_facet	Ángel Estella Mª Luisa Cantón Laura Muñoz Isabel Rodriguez Higueras María Recuerda Núñez Julia Tejero Aranguren Benito Zaya Carmen Gómez Rosario Amaya Ángela Hurtado Martinez María del Valle Odero Bernal Carmen De la Fuente Juan Carlos Alados Jose Garnacho-Montero on behalf of the Group of Infectious Diseases of the Andalusian Society of Intensive Care and Coronary Units SAMIUC
author_sort	Ángel Estella
title	Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study
title_short	Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study
title_full	Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study
title_fullStr	Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study
title_full_unstemmed	Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study
title_sort	vaccinated patients admitted in icu with severe pneumonia due to sars-cov-2: a multicenter pilot study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ac691f79160c4104a33718551dc8708e
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Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study

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