Fibroblast Growth Factor-23-Klotho Axis in Cardiorenal Syndrome: Mediators and Potential Therapeutic Targets

Cardiorenal syndrome (CRS) is a complex disorder that refers to the category of acute or chronic kidney diseases that induce cardiovascular disease, and inversely, acute or chronic heart diseases that provoke kidney dysfunction. There is a close relationship between renal and cardiovascular disease,...

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Autores principales:	José Alberto Navarro-García, Laura González-Lafuente, María Fernández-Velasco, Luis M. Ruilope, Gema Ruiz-Hurtado
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	FGF-23 Klotho cardiorenal syndrome chronic kidney disease acute kidney injury dialysis Physiology QP1-981
Acceso en línea:	https://doaj.org/article/ac6da582782d4dc9a8681efa0f0a5d0f
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spelling	oai:doaj.org-article:ac6da582782d4dc9a8681efa0f0a5d0f2021-11-15T06:48:27ZFibroblast Growth Factor-23-Klotho Axis in Cardiorenal Syndrome: Mediators and Potential Therapeutic Targets1664-042X10.3389/fphys.2021.775029https://doaj.org/article/ac6da582782d4dc9a8681efa0f0a5d0f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.775029/fullhttps://doaj.org/toc/1664-042XCardiorenal syndrome (CRS) is a complex disorder that refers to the category of acute or chronic kidney diseases that induce cardiovascular disease, and inversely, acute or chronic heart diseases that provoke kidney dysfunction. There is a close relationship between renal and cardiovascular disease, possibly due to the presence of common risk factors for both diseases. Thus, it is well known that renal diseases are associated with increased risk of developing cardiovascular disease, suffering cardiac events and even mortality, which is aggravated in those patients with end-stage renal disease or who are undergoing dialysis. Recent works have proposed mineral bone disorders (MBD) as the possible link between kidney dysfunction and the development of cardiovascular outcomes. Traditionally, increased serum phosphate levels have been proposed as one of the main factors responsible for cardiovascular damage in kidney patients. However, recent studies have focused on other MBD components such as the elevation of fibroblast growth factor (FGF)-23, a phosphaturic bone-derived hormone, and the decreased expression of the anti-aging factor Klotho in renal patients. It has been shown that increased FGF-23 levels induce cardiac hypertrophy and dysfunction and are associated with increased cardiovascular mortality in renal patients. Decreased Klotho expression occurs as renal function declines. Despite its expression being absent in myocardial tissue, several studies have demonstrated that this antiaging factor plays a cardioprotective role, especially under elevated FGF-23 levels. The present review aims to collect the recent knowledge about the FGF-23-Klotho axis in the connection between kidney and heart, focusing on their specific role as new therapeutic targets in CRS.José Alberto Navarro-GarcíaLaura González-LafuenteMaría Fernández-VelascoLuis M. RuilopeLuis M. RuilopeLuis M. RuilopeGema Ruiz-HurtadoGema Ruiz-HurtadoFrontiers Media S.A.articleFGF-23Klothocardiorenal syndromechronic kidney diseaseacute kidney injurydialysisPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	FGF-23 Klotho cardiorenal syndrome chronic kidney disease acute kidney injury dialysis Physiology QP1-981
spellingShingle	FGF-23 Klotho cardiorenal syndrome chronic kidney disease acute kidney injury dialysis Physiology QP1-981 José Alberto Navarro-García Laura González-Lafuente María Fernández-Velasco Luis M. Ruilope Luis M. Ruilope Luis M. Ruilope Gema Ruiz-Hurtado Gema Ruiz-Hurtado Fibroblast Growth Factor-23-Klotho Axis in Cardiorenal Syndrome: Mediators and Potential Therapeutic Targets
description	Cardiorenal syndrome (CRS) is a complex disorder that refers to the category of acute or chronic kidney diseases that induce cardiovascular disease, and inversely, acute or chronic heart diseases that provoke kidney dysfunction. There is a close relationship between renal and cardiovascular disease, possibly due to the presence of common risk factors for both diseases. Thus, it is well known that renal diseases are associated with increased risk of developing cardiovascular disease, suffering cardiac events and even mortality, which is aggravated in those patients with end-stage renal disease or who are undergoing dialysis. Recent works have proposed mineral bone disorders (MBD) as the possible link between kidney dysfunction and the development of cardiovascular outcomes. Traditionally, increased serum phosphate levels have been proposed as one of the main factors responsible for cardiovascular damage in kidney patients. However, recent studies have focused on other MBD components such as the elevation of fibroblast growth factor (FGF)-23, a phosphaturic bone-derived hormone, and the decreased expression of the anti-aging factor Klotho in renal patients. It has been shown that increased FGF-23 levels induce cardiac hypertrophy and dysfunction and are associated with increased cardiovascular mortality in renal patients. Decreased Klotho expression occurs as renal function declines. Despite its expression being absent in myocardial tissue, several studies have demonstrated that this antiaging factor plays a cardioprotective role, especially under elevated FGF-23 levels. The present review aims to collect the recent knowledge about the FGF-23-Klotho axis in the connection between kidney and heart, focusing on their specific role as new therapeutic targets in CRS.
format	article
author	José Alberto Navarro-García Laura González-Lafuente María Fernández-Velasco Luis M. Ruilope Luis M. Ruilope Luis M. Ruilope Gema Ruiz-Hurtado Gema Ruiz-Hurtado
author_facet	José Alberto Navarro-García Laura González-Lafuente María Fernández-Velasco Luis M. Ruilope Luis M. Ruilope Luis M. Ruilope Gema Ruiz-Hurtado Gema Ruiz-Hurtado
author_sort	José Alberto Navarro-García
title	Fibroblast Growth Factor-23-Klotho Axis in Cardiorenal Syndrome: Mediators and Potential Therapeutic Targets
title_short	Fibroblast Growth Factor-23-Klotho Axis in Cardiorenal Syndrome: Mediators and Potential Therapeutic Targets
title_full	Fibroblast Growth Factor-23-Klotho Axis in Cardiorenal Syndrome: Mediators and Potential Therapeutic Targets
title_fullStr	Fibroblast Growth Factor-23-Klotho Axis in Cardiorenal Syndrome: Mediators and Potential Therapeutic Targets
title_full_unstemmed	Fibroblast Growth Factor-23-Klotho Axis in Cardiorenal Syndrome: Mediators and Potential Therapeutic Targets
title_sort	fibroblast growth factor-23-klotho axis in cardiorenal syndrome: mediators and potential therapeutic targets
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ac6da582782d4dc9a8681efa0f0a5d0f
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Fibroblast Growth Factor-23-Klotho Axis in Cardiorenal Syndrome: Mediators and Potential Therapeutic Targets

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