JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency
Previous work suggested that histone demethylase JMJD3 is detrimental to somatic cell reprogramming. Here, the authors show that while JMJD3 has a context-independent detrimental effect on early stages of reprogramming, during late stages it activates epithelial and pluripotency genes together with...
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Nature Portfolio
2020
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oai:doaj.org-article:ac78b96cad84437384cee675241f1bdb2021-12-02T19:16:29ZJMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency10.1038/s41467-020-18900-z2041-1723https://doaj.org/article/ac78b96cad84437384cee675241f1bdb2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18900-zhttps://doaj.org/toc/2041-1723Previous work suggested that histone demethylase JMJD3 is detrimental to somatic cell reprogramming. Here, the authors show that while JMJD3 has a context-independent detrimental effect on early stages of reprogramming, during late stages it activates epithelial and pluripotency genes together with Klf4.Yinghua HuangHui ZhangLulu WangChuanqing TangXiaogan QinXinyu WuMeifang PanYujia TangZhongzhou YangIsaac A. BabarindeRunxia LinGuanyu JiYiwei LaiXueting XuJianbin SuXue WenTakashi SatohTanveer AhmedVikas MalikCarl WardGiacomo VolpeLin GuoJinlong ChenLi SunYingying LiXiaofen HuangXichen BaoFei GaoBaohua LiuHui ZhengRalf JauchLiangxue LaiGuangjin PanJiekai ChenGiuseppe TestaShizuo AkiraJifan HuDuanqing PeiAndrew P. HutchinsMiguel A. EstebanBaoming QinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yinghua Huang Hui Zhang Lulu Wang Chuanqing Tang Xiaogan Qin Xinyu Wu Meifang Pan Yujia Tang Zhongzhou Yang Isaac A. Babarinde Runxia Lin Guanyu Ji Yiwei Lai Xueting Xu Jianbin Su Xue Wen Takashi Satoh Tanveer Ahmed Vikas Malik Carl Ward Giacomo Volpe Lin Guo Jinlong Chen Li Sun Yingying Li Xiaofen Huang Xichen Bao Fei Gao Baohua Liu Hui Zheng Ralf Jauch Liangxue Lai Guangjin Pan Jiekai Chen Giuseppe Testa Shizuo Akira Jifan Hu Duanqing Pei Andrew P. Hutchins Miguel A. Esteban Baoming Qin JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency |
| description |
Previous work suggested that histone demethylase JMJD3 is detrimental to somatic cell reprogramming. Here, the authors show that while JMJD3 has a context-independent detrimental effect on early stages of reprogramming, during late stages it activates epithelial and pluripotency genes together with Klf4. |
| format |
article |
| author |
Yinghua Huang Hui Zhang Lulu Wang Chuanqing Tang Xiaogan Qin Xinyu Wu Meifang Pan Yujia Tang Zhongzhou Yang Isaac A. Babarinde Runxia Lin Guanyu Ji Yiwei Lai Xueting Xu Jianbin Su Xue Wen Takashi Satoh Tanveer Ahmed Vikas Malik Carl Ward Giacomo Volpe Lin Guo Jinlong Chen Li Sun Yingying Li Xiaofen Huang Xichen Bao Fei Gao Baohua Liu Hui Zheng Ralf Jauch Liangxue Lai Guangjin Pan Jiekai Chen Giuseppe Testa Shizuo Akira Jifan Hu Duanqing Pei Andrew P. Hutchins Miguel A. Esteban Baoming Qin |
| author_facet |
Yinghua Huang Hui Zhang Lulu Wang Chuanqing Tang Xiaogan Qin Xinyu Wu Meifang Pan Yujia Tang Zhongzhou Yang Isaac A. Babarinde Runxia Lin Guanyu Ji Yiwei Lai Xueting Xu Jianbin Su Xue Wen Takashi Satoh Tanveer Ahmed Vikas Malik Carl Ward Giacomo Volpe Lin Guo Jinlong Chen Li Sun Yingying Li Xiaofen Huang Xichen Bao Fei Gao Baohua Liu Hui Zheng Ralf Jauch Liangxue Lai Guangjin Pan Jiekai Chen Giuseppe Testa Shizuo Akira Jifan Hu Duanqing Pei Andrew P. Hutchins Miguel A. Esteban Baoming Qin |
| author_sort |
Yinghua Huang |
| title |
JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency |
| title_short |
JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency |
| title_full |
JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency |
| title_fullStr |
JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency |
| title_full_unstemmed |
JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency |
| title_sort |
jmjd3 acts in tandem with klf4 to facilitate reprogramming to pluripotency |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/ac78b96cad84437384cee675241f1bdb |
| work_keys_str_mv |
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