Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase

Amitai et al. identified 4 potential small molecule antidotes toward nerve agents poisoning by high-throughput-screening of over 150,000 compounds. Unique non-quaternary oximes represent new potential antidotes for future development as they detoxified nerve agents and also reactivated nerve agent-i...

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Autores principales:	Gabriel Amitai, Alexander Plotnikov, Shira Chapman, Shlomi Lazar, Rellie Gez, Dan Loewenthal, Khriesto A. Shurrush, Galit Cohen, Leonardo J. Solmesky, Haim Barr, Alan J. Russell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ac7bf1ed74314e84bce92d5d5c901cca
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spelling	oai:doaj.org-article:ac7bf1ed74314e84bce92d5d5c901cca2021-12-02T17:16:14ZNon-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase10.1038/s42003-021-02061-w2399-3642https://doaj.org/article/ac7bf1ed74314e84bce92d5d5c901cca2021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02061-whttps://doaj.org/toc/2399-3642Amitai et al. identified 4 potential small molecule antidotes toward nerve agents poisoning by high-throughput-screening of over 150,000 compounds. Unique non-quaternary oximes represent new potential antidotes for future development as they detoxified nerve agents and also reactivated nerve agent-inhibited butyrylcholinesterase.Gabriel AmitaiAlexander PlotnikovShira ChapmanShlomi LazarRellie GezDan LoewenthalKhriesto A. ShurrushGalit CohenLeonardo J. SolmeskyHaim BarrAlan J. RussellNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Gabriel Amitai Alexander Plotnikov Shira Chapman Shlomi Lazar Rellie Gez Dan Loewenthal Khriesto A. Shurrush Galit Cohen Leonardo J. Solmesky Haim Barr Alan J. Russell Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase
description	Amitai et al. identified 4 potential small molecule antidotes toward nerve agents poisoning by high-throughput-screening of over 150,000 compounds. Unique non-quaternary oximes represent new potential antidotes for future development as they detoxified nerve agents and also reactivated nerve agent-inhibited butyrylcholinesterase.
format	article
author	Gabriel Amitai Alexander Plotnikov Shira Chapman Shlomi Lazar Rellie Gez Dan Loewenthal Khriesto A. Shurrush Galit Cohen Leonardo J. Solmesky Haim Barr Alan J. Russell
author_facet	Gabriel Amitai Alexander Plotnikov Shira Chapman Shlomi Lazar Rellie Gez Dan Loewenthal Khriesto A. Shurrush Galit Cohen Leonardo J. Solmesky Haim Barr Alan J. Russell
author_sort	Gabriel Amitai
title	Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase
title_short	Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase
title_full	Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase
title_fullStr	Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase
title_full_unstemmed	Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase
title_sort	non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ac7bf1ed74314e84bce92d5d5c901cca
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Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase

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