Role of the Microenvironment in Mesenchymal Stem Cell-Based Strategies for Treating Human Liver Diseases

Liver disease is a severe health problem that endangers human health worldwide. Mesenchymal stem cell (MSC) therapy is a novel treatment for patients with different liver diseases due to its vast expansion potential and distinctive immunomodulatory properties. Despite several preclinical trials havi...

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Autores principales:	Shan-jing Xu, Li-ping Ye, Wei Wang, Ya-hong Chen, Jian Dong, Xin-li Mao, Shao-wei Li
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Internal medicine RC31-1245
Acceso en línea:	https://doaj.org/article/ac7d028edac647b7883ba82f69d87287
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spelling	oai:doaj.org-article:ac7d028edac647b7883ba82f69d872872021-11-29T00:56:11ZRole of the Microenvironment in Mesenchymal Stem Cell-Based Strategies for Treating Human Liver Diseases1687-967810.1155/2021/5513309https://doaj.org/article/ac7d028edac647b7883ba82f69d872872021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5513309https://doaj.org/toc/1687-9678Liver disease is a severe health problem that endangers human health worldwide. Mesenchymal stem cell (MSC) therapy is a novel treatment for patients with different liver diseases due to its vast expansion potential and distinctive immunomodulatory properties. Despite several preclinical trials having confirmed the considerable efficacy of MSC therapy in liver diseases, the questionable safety and efficacy still limit its application. As a precursor cell, MSCs can adjust their characteristics in response to the surrounding microenvironment. The microenvironment provides physical and chemical factors essential for stem cell survival, proliferation, and differentiation. However, the mechanisms are still not completely understood. We, therefore, summarized the mechanisms underlying the MSC immune response, especially the interaction between MSCs and the liver microenvironment, discussing how to achieve better therapeutic effects.Shan-jing XuLi-ping YeWei WangYa-hong ChenJian DongXin-li MaoShao-wei LiHindawi LimitedarticleInternal medicineRC31-1245ENStem Cells International, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Internal medicine RC31-1245
spellingShingle	Internal medicine RC31-1245 Shan-jing Xu Li-ping Ye Wei Wang Ya-hong Chen Jian Dong Xin-li Mao Shao-wei Li Role of the Microenvironment in Mesenchymal Stem Cell-Based Strategies for Treating Human Liver Diseases
description	Liver disease is a severe health problem that endangers human health worldwide. Mesenchymal stem cell (MSC) therapy is a novel treatment for patients with different liver diseases due to its vast expansion potential and distinctive immunomodulatory properties. Despite several preclinical trials having confirmed the considerable efficacy of MSC therapy in liver diseases, the questionable safety and efficacy still limit its application. As a precursor cell, MSCs can adjust their characteristics in response to the surrounding microenvironment. The microenvironment provides physical and chemical factors essential for stem cell survival, proliferation, and differentiation. However, the mechanisms are still not completely understood. We, therefore, summarized the mechanisms underlying the MSC immune response, especially the interaction between MSCs and the liver microenvironment, discussing how to achieve better therapeutic effects.
format	article
author	Shan-jing Xu Li-ping Ye Wei Wang Ya-hong Chen Jian Dong Xin-li Mao Shao-wei Li
author_facet	Shan-jing Xu Li-ping Ye Wei Wang Ya-hong Chen Jian Dong Xin-li Mao Shao-wei Li
author_sort	Shan-jing Xu
title	Role of the Microenvironment in Mesenchymal Stem Cell-Based Strategies for Treating Human Liver Diseases
title_short	Role of the Microenvironment in Mesenchymal Stem Cell-Based Strategies for Treating Human Liver Diseases
title_full	Role of the Microenvironment in Mesenchymal Stem Cell-Based Strategies for Treating Human Liver Diseases
title_fullStr	Role of the Microenvironment in Mesenchymal Stem Cell-Based Strategies for Treating Human Liver Diseases
title_full_unstemmed	Role of the Microenvironment in Mesenchymal Stem Cell-Based Strategies for Treating Human Liver Diseases
title_sort	role of the microenvironment in mesenchymal stem cell-based strategies for treating human liver diseases
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/ac7d028edac647b7883ba82f69d87287
work_keys_str_mv	AT shanjingxu roleofthemicroenvironmentinmesenchymalstemcellbasedstrategiesfortreatinghumanliverdiseases AT lipingye roleofthemicroenvironmentinmesenchymalstemcellbasedstrategiesfortreatinghumanliverdiseases AT weiwang roleofthemicroenvironmentinmesenchymalstemcellbasedstrategiesfortreatinghumanliverdiseases AT yahongchen roleofthemicroenvironmentinmesenchymalstemcellbasedstrategiesfortreatinghumanliverdiseases AT jiandong roleofthemicroenvironmentinmesenchymalstemcellbasedstrategiesfortreatinghumanliverdiseases AT xinlimao roleofthemicroenvironmentinmesenchymalstemcellbasedstrategiesfortreatinghumanliverdiseases AT shaoweili roleofthemicroenvironmentinmesenchymalstemcellbasedstrategiesfortreatinghumanliverdiseases
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Role of the Microenvironment in Mesenchymal Stem Cell-Based Strategies for Treating Human Liver Diseases

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