CUG-binding protein 1 regulates HSC activation and liver fibrogenesis

CUG-binding protein 1 regulates HSC activation and liver fibrogenesis

Activation of hepatic stellate cells is a critical event in the development of fibrosis, which is driven by TGF-beta and inhibited by IFN-gamma. Here Wu et al. show that the RNA binding protein CUGBP1 is increased by TGF-beta signalling and promotes IFN-gamma mRNA degradation.

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Autores principales: Xingxin Wu, Xudong Wu, Yuxiang Ma, Fenli Shao, Yang Tan, Tao Tan, Liyun Gu, Yang Zhou, Beicheng Sun, Yang Sun, Xuefeng Wu, Qiang Xu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Q
Acceso en línea:https://doaj.org/article/ac7fe1e98e6e47c8a1df5add0cbe24dc
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spelling oai:doaj.org-article:ac7fe1e98e6e47c8a1df5add0cbe24dc2021-12-02T15:35:45ZCUG-binding protein 1 regulates HSC activation and liver fibrogenesis10.1038/ncomms134982041-1723https://doaj.org/article/ac7fe1e98e6e47c8a1df5add0cbe24dc2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13498https://doaj.org/toc/2041-1723Activation of hepatic stellate cells is a critical event in the development of fibrosis, which is driven by TGF-beta and inhibited by IFN-gamma. Here Wu et al. show that the RNA binding protein CUGBP1 is increased by TGF-beta signalling and promotes IFN-gamma mRNA degradation.Xingxin WuXudong WuYuxiang MaFenli ShaoYang TanTao TanLiyun GuYang ZhouBeicheng SunYang SunXuefeng WuQiang XuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xingxin Wu
Xudong Wu
Yuxiang Ma
Fenli Shao
Yang Tan
Tao Tan
Liyun Gu
Yang Zhou
Beicheng Sun
Yang Sun
Xuefeng Wu
Qiang Xu
CUG-binding protein 1 regulates HSC activation and liver fibrogenesis
description Activation of hepatic stellate cells is a critical event in the development of fibrosis, which is driven by TGF-beta and inhibited by IFN-gamma. Here Wu et al. show that the RNA binding protein CUGBP1 is increased by TGF-beta signalling and promotes IFN-gamma mRNA degradation.
format article
author Xingxin Wu
Xudong Wu
Yuxiang Ma
Fenli Shao
Yang Tan
Tao Tan
Liyun Gu
Yang Zhou
Beicheng Sun
Yang Sun
Xuefeng Wu
Qiang Xu
author_facet Xingxin Wu
Xudong Wu
Yuxiang Ma
Fenli Shao
Yang Tan
Tao Tan
Liyun Gu
Yang Zhou
Beicheng Sun
Yang Sun
Xuefeng Wu
Qiang Xu
author_sort Xingxin Wu
title CUG-binding protein 1 regulates HSC activation and liver fibrogenesis
title_short CUG-binding protein 1 regulates HSC activation and liver fibrogenesis
title_full CUG-binding protein 1 regulates HSC activation and liver fibrogenesis
title_fullStr CUG-binding protein 1 regulates HSC activation and liver fibrogenesis
title_full_unstemmed CUG-binding protein 1 regulates HSC activation and liver fibrogenesis
title_sort cug-binding protein 1 regulates hsc activation and liver fibrogenesis
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/ac7fe1e98e6e47c8a1df5add0cbe24dc
work_keys_str_mv AT xingxinwu cugbindingprotein1regulateshscactivationandliverfibrogenesis
AT xudongwu cugbindingprotein1regulateshscactivationandliverfibrogenesis
AT yuxiangma cugbindingprotein1regulateshscactivationandliverfibrogenesis
AT fenlishao cugbindingprotein1regulateshscactivationandliverfibrogenesis
AT yangtan cugbindingprotein1regulateshscactivationandliverfibrogenesis
AT taotan cugbindingprotein1regulateshscactivationandliverfibrogenesis
AT liyungu cugbindingprotein1regulateshscactivationandliverfibrogenesis
AT yangzhou cugbindingprotein1regulateshscactivationandliverfibrogenesis
AT beichengsun cugbindingprotein1regulateshscactivationandliverfibrogenesis
AT yangsun cugbindingprotein1regulateshscactivationandliverfibrogenesis
AT xuefengwu cugbindingprotein1regulateshscactivationandliverfibrogenesis
AT qiangxu cugbindingprotein1regulateshscactivationandliverfibrogenesis
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