The durability of sitagliptin in elderly patients with type 2 diabetes

Ching-Jung Hsieh, Feng-Chih Shen Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan Aim: To evaluate the durability of sitagli...

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Autores principales: Hsieh CJ, Shen FC
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Publicado: Dove Medical Press 2014
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spelling oai:doaj.org-article:ac817c4695f84725b3ff6c9f1349316b2021-12-02T06:36:18ZThe durability of sitagliptin in elderly patients with type 2 diabetes1178-1998https://doaj.org/article/ac817c4695f84725b3ff6c9f1349316b2014-11-01T00:00:00Zhttps://www.dovepress.com/the-durability-of-sitagliptin-in-elderly-patients-withnbsptype-2-diabe-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Ching-Jung Hsieh, Feng-Chih Shen Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan Aim: To evaluate the durability of sitagliptin and to assess changes in clinical chronic complications following sitagliptin monotherapy for 48 months in elderly patients with type 2 diabetes mellitus (T2DM).Subjects and methods: We enrolled 76 drug-naïve patients (40 women and 36 men; mean age: 71.3±11.7 years) with T2DM who received 25–100 mg of sitagliptin therapy from an outpatient clinic. The observational period for each patient was >48 months, beginning at the time sitagliptin therapy was initiated. The following were measured or performed at the beginning of each year: body mass index; serum total cholesterol, low-density lipoprotein, high-density lipoprotein; triglyceride levels; creatinine (Cr) levels; urine albumin and urine Cr; nonmydriatic fundusgraphy; and semiquantified neuropathy. The fasting plasma glucose and glycated hemoglobin (HbA1c) was measured every 3–6 months.Results: The change in HbA1c was significantly reduced after 6 months of therapy (7.1%±0.8% to 6.3%±0.2%). No changes in fasting plasma glucose, Cr, serum total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein, body mass index, and microvascular complications were apparent. Using repeated measures to test the sequential changes in HbA1c from month 6 to month 48, the test of within-subjects effect was not significant (P=0.34).Conclusion: Sitagliptin has a durable effect and stabilizes microvascular complication progression in elderly patients. This study can provide useful data for clinicians and health care professionals using sitagliptin monotherapy in the treatment of elderly patients with T2DM. Keywords: type 2 diabetes mellitus, sitagliptin, oral antidiabetic drugs, dipeptidyl peptidase IV inhibitorHsieh CJShen FCDove Medical PressarticleType 2 diabetesSitagliptinOral anti-diabetic drugsDipeptidyl peptidase IV inhibitorGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 9, Pp 1905-1911 (2014)
institution DOAJ
collection DOAJ
language EN
topic Type 2 diabetes
Sitagliptin
Oral anti-diabetic drugs
Dipeptidyl peptidase IV inhibitor
Geriatrics
RC952-954.6
spellingShingle Type 2 diabetes
Sitagliptin
Oral anti-diabetic drugs
Dipeptidyl peptidase IV inhibitor
Geriatrics
RC952-954.6
Hsieh CJ
Shen FC
The durability of sitagliptin in elderly patients with type 2 diabetes
description Ching-Jung Hsieh, Feng-Chih Shen Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan Aim: To evaluate the durability of sitagliptin and to assess changes in clinical chronic complications following sitagliptin monotherapy for 48 months in elderly patients with type 2 diabetes mellitus (T2DM).Subjects and methods: We enrolled 76 drug-naïve patients (40 women and 36 men; mean age: 71.3±11.7 years) with T2DM who received 25–100 mg of sitagliptin therapy from an outpatient clinic. The observational period for each patient was >48 months, beginning at the time sitagliptin therapy was initiated. The following were measured or performed at the beginning of each year: body mass index; serum total cholesterol, low-density lipoprotein, high-density lipoprotein; triglyceride levels; creatinine (Cr) levels; urine albumin and urine Cr; nonmydriatic fundusgraphy; and semiquantified neuropathy. The fasting plasma glucose and glycated hemoglobin (HbA1c) was measured every 3–6 months.Results: The change in HbA1c was significantly reduced after 6 months of therapy (7.1%±0.8% to 6.3%±0.2%). No changes in fasting plasma glucose, Cr, serum total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein, body mass index, and microvascular complications were apparent. Using repeated measures to test the sequential changes in HbA1c from month 6 to month 48, the test of within-subjects effect was not significant (P=0.34).Conclusion: Sitagliptin has a durable effect and stabilizes microvascular complication progression in elderly patients. This study can provide useful data for clinicians and health care professionals using sitagliptin monotherapy in the treatment of elderly patients with T2DM. Keywords: type 2 diabetes mellitus, sitagliptin, oral antidiabetic drugs, dipeptidyl peptidase IV inhibitor
format article
author Hsieh CJ
Shen FC
author_facet Hsieh CJ
Shen FC
author_sort Hsieh CJ
title The durability of sitagliptin in elderly patients with type 2 diabetes
title_short The durability of sitagliptin in elderly patients with type 2 diabetes
title_full The durability of sitagliptin in elderly patients with type 2 diabetes
title_fullStr The durability of sitagliptin in elderly patients with type 2 diabetes
title_full_unstemmed The durability of sitagliptin in elderly patients with type 2 diabetes
title_sort durability of sitagliptin in elderly patients with type 2 diabetes
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/ac817c4695f84725b3ff6c9f1349316b
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