Radiotherapy for inoperable Merkel cell carcinoma: a systematic review and pooled analysis

Background: Cumulative data on radiation monotherapy for Merkel cell carcinoma (MCC) is lacking. Objective: We sought to synthesize all available data on treatment outcomes for radiation monotherapy for inoperable stage I-III MCC. Methods: We performed a systematic review of the current liter...

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Autores principales:	Parth Patel, Chirag Modi, Beth McLellan, Nitin Ohri
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2018
Materias:	Merkel cell carcinoma radiotherapy inoperable relapse survival Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/ac83a7cd24ef40359c96133ff39de7ab
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spelling	oai:doaj.org-article:ac83a7cd24ef40359c96133ff39de7ab2021-11-17T08:30:11ZRadiotherapy for inoperable Merkel cell carcinoma: a systematic review and pooled analysis2160-9381https://doaj.org/article/ac83a7cd24ef40359c96133ff39de7ab2018-04-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/433https://doaj.org/toc/2160-9381 Background: Cumulative data on radiation monotherapy for Merkel cell carcinoma (MCC) is lacking. Objective: We sought to synthesize all available data on treatment outcomes for radiation monotherapy for inoperable stage I-III MCC. Methods: We performed a systematic review of the current literature. Articles published in English in the PUBMED database up to July 29, 2016 were evaluated. Results: Eight case reports, 4 case series, and 6 retrospective studies, yielding 68 patients, were included in our analysis. Of the 24 stage I/II patients treated with local irradiation, 6 (25%) relapsed and 1 (4%) died from MCC. Of the 24 stage I/II patients treated with local and regional nodal irradiation, 5 (21%) relapsed and 2 (8%) died from MCC. Of the 20 stage III patients treated with local and regional nodal irradiation, 12 (60%) relapsed and 7 (35%) died from MCC. Conclusions: Radiation monotherapy appears to be a reasonable treatment modality for patients with inoperable stage I-III MCC. Further investigation with prospective studies is needed to draw definitive conclusions. Parth PatelChirag ModiBeth McLellanNitin OhriMattioli1885articleMerkel cell carcinomaradiotherapyinoperablerelapsesurvivalDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 8, Iss 1 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Merkel cell carcinoma radiotherapy inoperable relapse survival Dermatology RL1-803
spellingShingle	Merkel cell carcinoma radiotherapy inoperable relapse survival Dermatology RL1-803 Parth Patel Chirag Modi Beth McLellan Nitin Ohri Radiotherapy for inoperable Merkel cell carcinoma: a systematic review and pooled analysis
description	Background: Cumulative data on radiation monotherapy for Merkel cell carcinoma (MCC) is lacking. Objective: We sought to synthesize all available data on treatment outcomes for radiation monotherapy for inoperable stage I-III MCC. Methods: We performed a systematic review of the current literature. Articles published in English in the PUBMED database up to July 29, 2016 were evaluated. Results: Eight case reports, 4 case series, and 6 retrospective studies, yielding 68 patients, were included in our analysis. Of the 24 stage I/II patients treated with local irradiation, 6 (25%) relapsed and 1 (4%) died from MCC. Of the 24 stage I/II patients treated with local and regional nodal irradiation, 5 (21%) relapsed and 2 (8%) died from MCC. Of the 20 stage III patients treated with local and regional nodal irradiation, 12 (60%) relapsed and 7 (35%) died from MCC. Conclusions: Radiation monotherapy appears to be a reasonable treatment modality for patients with inoperable stage I-III MCC. Further investigation with prospective studies is needed to draw definitive conclusions.
format	article
author	Parth Patel Chirag Modi Beth McLellan Nitin Ohri
author_facet	Parth Patel Chirag Modi Beth McLellan Nitin Ohri
author_sort	Parth Patel
title	Radiotherapy for inoperable Merkel cell carcinoma: a systematic review and pooled analysis
title_short	Radiotherapy for inoperable Merkel cell carcinoma: a systematic review and pooled analysis
title_full	Radiotherapy for inoperable Merkel cell carcinoma: a systematic review and pooled analysis
title_fullStr	Radiotherapy for inoperable Merkel cell carcinoma: a systematic review and pooled analysis
title_full_unstemmed	Radiotherapy for inoperable Merkel cell carcinoma: a systematic review and pooled analysis
title_sort	radiotherapy for inoperable merkel cell carcinoma: a systematic review and pooled analysis
publisher	Mattioli1885
publishDate	2018
url	https://doaj.org/article/ac83a7cd24ef40359c96133ff39de7ab
work_keys_str_mv	AT parthpatel radiotherapyforinoperablemerkelcellcarcinomaasystematicreviewandpooledanalysis AT chiragmodi radiotherapyforinoperablemerkelcellcarcinomaasystematicreviewandpooledanalysis AT bethmclellan radiotherapyforinoperablemerkelcellcarcinomaasystematicreviewandpooledanalysis AT nitinohri radiotherapyforinoperablemerkelcellcarcinomaasystematicreviewandpooledanalysis
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Radiotherapy for inoperable Merkel cell carcinoma: a systematic review and pooled analysis

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