Lifespan Gyrification Trajectories of Human Brain in Healthy Individuals and Patients with Major Psychiatric Disorders

Abstract Cortical gyrification of the brain represents the folding characteristic of the cerebral cortex. How the brain cortical gyrification changes from childhood to old age in healthy human subjects is still unclear. Additionally, studies have shown regional gyrification alterations in patients w...

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Autores principales:	Bo Cao, Benson Mwangi, Ives Cavalcante Passos, Mon-Ju Wu, Zafer Keser, Giovana B. Zunta-Soares, Dianping Xu, Khader M. Hasan, Jair C. Soares
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ac84c0b7eea64d51b9fe56f7d27ad75a
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spelling	oai:doaj.org-article:ac84c0b7eea64d51b9fe56f7d27ad75a2021-12-02T16:06:08ZLifespan Gyrification Trajectories of Human Brain in Healthy Individuals and Patients with Major Psychiatric Disorders10.1038/s41598-017-00582-12045-2322https://doaj.org/article/ac84c0b7eea64d51b9fe56f7d27ad75a2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00582-1https://doaj.org/toc/2045-2322Abstract Cortical gyrification of the brain represents the folding characteristic of the cerebral cortex. How the brain cortical gyrification changes from childhood to old age in healthy human subjects is still unclear. Additionally, studies have shown regional gyrification alterations in patients with major psychiatric disorders, such as major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ). However, whether the lifespan trajectory of gyrification over the brain is altered in patients diagnosed with major psychiatric disorders is still unknown. In this study, we investigated the trajectories of gyrification in three independent cohorts based on structural brain images of 881 subjects from age 4 to 83. We discovered that the trajectory of gyrification during normal development and aging was not linear and could be modeled with a logarithmic function. We also found that the gyrification trajectories of patients with MDD, BD and SCZ were deviated from the healthy one during adulthood, indicating altered aging in the brain of these patients.Bo CaoBenson MwangiIves Cavalcante PassosMon-Ju WuZafer KeserGiovana B. Zunta-SoaresDianping XuKhader M. HasanJair C. SoaresNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bo Cao Benson Mwangi Ives Cavalcante Passos Mon-Ju Wu Zafer Keser Giovana B. Zunta-Soares Dianping Xu Khader M. Hasan Jair C. Soares Lifespan Gyrification Trajectories of Human Brain in Healthy Individuals and Patients with Major Psychiatric Disorders
description	Abstract Cortical gyrification of the brain represents the folding characteristic of the cerebral cortex. How the brain cortical gyrification changes from childhood to old age in healthy human subjects is still unclear. Additionally, studies have shown regional gyrification alterations in patients with major psychiatric disorders, such as major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ). However, whether the lifespan trajectory of gyrification over the brain is altered in patients diagnosed with major psychiatric disorders is still unknown. In this study, we investigated the trajectories of gyrification in three independent cohorts based on structural brain images of 881 subjects from age 4 to 83. We discovered that the trajectory of gyrification during normal development and aging was not linear and could be modeled with a logarithmic function. We also found that the gyrification trajectories of patients with MDD, BD and SCZ were deviated from the healthy one during adulthood, indicating altered aging in the brain of these patients.
format	article
author	Bo Cao Benson Mwangi Ives Cavalcante Passos Mon-Ju Wu Zafer Keser Giovana B. Zunta-Soares Dianping Xu Khader M. Hasan Jair C. Soares
author_facet	Bo Cao Benson Mwangi Ives Cavalcante Passos Mon-Ju Wu Zafer Keser Giovana B. Zunta-Soares Dianping Xu Khader M. Hasan Jair C. Soares
author_sort	Bo Cao
title	Lifespan Gyrification Trajectories of Human Brain in Healthy Individuals and Patients with Major Psychiatric Disorders
title_short	Lifespan Gyrification Trajectories of Human Brain in Healthy Individuals and Patients with Major Psychiatric Disorders
title_full	Lifespan Gyrification Trajectories of Human Brain in Healthy Individuals and Patients with Major Psychiatric Disorders
title_fullStr	Lifespan Gyrification Trajectories of Human Brain in Healthy Individuals and Patients with Major Psychiatric Disorders
title_full_unstemmed	Lifespan Gyrification Trajectories of Human Brain in Healthy Individuals and Patients with Major Psychiatric Disorders
title_sort	lifespan gyrification trajectories of human brain in healthy individuals and patients with major psychiatric disorders
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ac84c0b7eea64d51b9fe56f7d27ad75a
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Lifespan Gyrification Trajectories of Human Brain in Healthy Individuals and Patients with Major Psychiatric Disorders

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