Correlates of insulin clearance in apparently healthy non-obese Japanese men
Abstract Hyperinsulinemia observed in obese subject is caused at least in part by low metabolic clearance rate of insulin (MCRI). However, the determinants of MCRI in non-obese subjects are not fully understood. To investigate the correlates of MCRI in healthy non-obese men (BMI <25 kg/m2), we st...
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2017
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oai:doaj.org-article:ac87977e48d44dd7ada656f806620cda2021-12-02T11:40:45ZCorrelates of insulin clearance in apparently healthy non-obese Japanese men10.1038/s41598-017-01469-x2045-2322https://doaj.org/article/ac87977e48d44dd7ada656f806620cda2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01469-xhttps://doaj.org/toc/2045-2322Abstract Hyperinsulinemia observed in obese subject is caused at least in part by low metabolic clearance rate of insulin (MCRI). However, the determinants of MCRI in non-obese subjects are not fully understood. To investigate the correlates of MCRI in healthy non-obese men (BMI <25 kg/m2), we studied 49 non-obese Japanese men free of cardiometabolic risk factors. Using a 2-step hyperinsulinemic euglycemic clamp, we evaluated MCRI and insulin sensitivity. We also calculated the rate of glucose disappearance (Rd) during the clamp and muscle insulin sensitivity was defined as Rd/steady state serum insulin (SSSI) at the second step. Based on the median value of MCRI, the subjects were divided into the low- and high-MCRI groups. Subjects of the low-MCRI group had significant impairment of muscle insulin sensitivity, although Rd levels were comparable between the two groups, probably due to elevated SSSI in the low-MCRI group. Subjects of the low-MCRI group had higher total body fat content and lower VO2peak and showed no deterioration of cardiometabolic risk factors. Our results suggest that low MCRI may be early change to maintain glucose uptake and metabolic status in the face of slight impairment of muscle insulin sensitivity caused by increased adiposity and lower fitness level.Hideyoshi KagaYoshifumi TamuraKageumi TakenoSaori KakehiTakashi FunayamaYasuhiko FurukawaMiho Nishitani-YokoyamaKazunori ShimadaHiroyuki DaidaShigeki AokiAdria GiaccaAkio KanazawaRyuzo KawamoriHirotaka WatadaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017) |
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Medicine R Science Q Hideyoshi Kaga Yoshifumi Tamura Kageumi Takeno Saori Kakehi Takashi Funayama Yasuhiko Furukawa Miho Nishitani-Yokoyama Kazunori Shimada Hiroyuki Daida Shigeki Aoki Adria Giacca Akio Kanazawa Ryuzo Kawamori Hirotaka Watada Correlates of insulin clearance in apparently healthy non-obese Japanese men |
| description |
Abstract Hyperinsulinemia observed in obese subject is caused at least in part by low metabolic clearance rate of insulin (MCRI). However, the determinants of MCRI in non-obese subjects are not fully understood. To investigate the correlates of MCRI in healthy non-obese men (BMI <25 kg/m2), we studied 49 non-obese Japanese men free of cardiometabolic risk factors. Using a 2-step hyperinsulinemic euglycemic clamp, we evaluated MCRI and insulin sensitivity. We also calculated the rate of glucose disappearance (Rd) during the clamp and muscle insulin sensitivity was defined as Rd/steady state serum insulin (SSSI) at the second step. Based on the median value of MCRI, the subjects were divided into the low- and high-MCRI groups. Subjects of the low-MCRI group had significant impairment of muscle insulin sensitivity, although Rd levels were comparable between the two groups, probably due to elevated SSSI in the low-MCRI group. Subjects of the low-MCRI group had higher total body fat content and lower VO2peak and showed no deterioration of cardiometabolic risk factors. Our results suggest that low MCRI may be early change to maintain glucose uptake and metabolic status in the face of slight impairment of muscle insulin sensitivity caused by increased adiposity and lower fitness level. |
| format |
article |
| author |
Hideyoshi Kaga Yoshifumi Tamura Kageumi Takeno Saori Kakehi Takashi Funayama Yasuhiko Furukawa Miho Nishitani-Yokoyama Kazunori Shimada Hiroyuki Daida Shigeki Aoki Adria Giacca Akio Kanazawa Ryuzo Kawamori Hirotaka Watada |
| author_facet |
Hideyoshi Kaga Yoshifumi Tamura Kageumi Takeno Saori Kakehi Takashi Funayama Yasuhiko Furukawa Miho Nishitani-Yokoyama Kazunori Shimada Hiroyuki Daida Shigeki Aoki Adria Giacca Akio Kanazawa Ryuzo Kawamori Hirotaka Watada |
| author_sort |
Hideyoshi Kaga |
| title |
Correlates of insulin clearance in apparently healthy non-obese Japanese men |
| title_short |
Correlates of insulin clearance in apparently healthy non-obese Japanese men |
| title_full |
Correlates of insulin clearance in apparently healthy non-obese Japanese men |
| title_fullStr |
Correlates of insulin clearance in apparently healthy non-obese Japanese men |
| title_full_unstemmed |
Correlates of insulin clearance in apparently healthy non-obese Japanese men |
| title_sort |
correlates of insulin clearance in apparently healthy non-obese japanese men |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/ac87977e48d44dd7ada656f806620cda |
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1718395538631557120 |