Microbiology of primary acquired nasolacrimal duct obstruction: simple epiphora, acute dacryocystitis, and chronic dacryocystitis

Kanograt Pornpanich,1 Panitee Luemsamran,1 Amornrut Leelaporn,2 Jiraporn Santisuk,3 Nattaporn Tesavibul,1 Buntitar Lertsuwanroj,1 Sumalee Vangveeravong1 1Department of Ophthalmology, 2Department of Microbiology, 3Eye Surgery Unit, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok,...

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Autores principales:	Pornpanich K, Luemsamran P, Leelaporn A, Santisuk J, Tesavibul N, Lertsuwanroj B, Vangveeravong S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Microbiology Acquired nasolacrimal duct obstruction simple epiphora acute dacryocystitis Chronic dacryocystitis Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/ac8919883edd4ae5b2921a042b9a6d6e
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spelling	oai:doaj.org-article:ac8919883edd4ae5b2921a042b9a6d6e2021-12-02T02:52:45ZMicrobiology of primary acquired nasolacrimal duct obstruction: simple epiphora, acute dacryocystitis, and chronic dacryocystitis1177-5483https://doaj.org/article/ac8919883edd4ae5b2921a042b9a6d6e2016-02-01T00:00:00Zhttps://www.dovepress.com/microbiology-of-primary-acquired-nasolacrimal-duct-obstruction-simple--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Kanograt Pornpanich,1 Panitee Luemsamran,1 Amornrut Leelaporn,2 Jiraporn Santisuk,3 Nattaporn Tesavibul,1 Buntitar Lertsuwanroj,1 Sumalee Vangveeravong1 1Department of Ophthalmology, 2Department of Microbiology, 3Eye Surgery Unit, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand Purpose: The aim of this study was to determine the microbiology of primary acquired nasolacrimal duct obstruction (PANDO) and its antimicrobial susceptibilities.Methods: Ninety-three patients (100 eyes) diagnosed with PANDO, categorized as acute, chronic dacryocystitis, or simple epiphora, were prospectively enrolled. Lacrimal sac contents were cultured for aerobic and anaerobic bacteria and fungi. Cultured organisms were identified, and antimicrobial susceptibility testing was performed for aerobic bacteria. Results: Seventy-nine of the 100 samples were culture positive. One hundred twenty-seven organisms were isolated, and 29 different species were identified. Most microorganisms were Gram-positive bacteria (45 samples or 57.0% of all positive culture samples), whereas Gram-negative bacteria, anaerobic bacteria, and fungi were found in 39 (49.4%), 24 (30.4%), and four samples (5.1%), respectively. The most frequently isolated group was coagulase-negative staphylococci (27.8%), followed by nonspore-forming Gram-positive rods (anaerobe) (17.7%) and Pseudomonas aeruginosa (15.2%). Of the 100 samples, five, 45, and 50 samples were obtained from patients with acute dacryocystitis, chronic dacryocystitis, and simple epiphora, respectively. Subgroup analysis showed that Gram-negative organisms were isolated more frequently from the chronic dacryocystitis subgroup than from the simple epiphora subgroup (P=0.012). Antimicrobial susceptibility testing demonstrated that ciprofloxacin was the most effective drug against all Gram-positive and Gram-negative organisms. Conclusion: Patients with PANDO, with or without clinical signs of lacrimal infection, were culture positive. Gram-negative organisms were frequently isolated, which were different from previous studies. Ciprofloxacin was the most effective agent against all Gram-positive and Gram-negative organisms. Keywords: microbiology, acquired nasolacrimal duct obstruction, simple epiphora, acute dacryocystitis, chronic dacryocystitis Pornpanich KLuemsamran PLeelaporn ASantisuk JTesavibul NLertsuwanroj BVangveeravong SDove Medical PressarticleMicrobiologyAcquired nasolacrimal duct obstructionsimple epiphoraacute dacryocystitisChronic dacryocystitisOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2016, Iss Issue 1, Pp 337-342 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology Acquired nasolacrimal duct obstruction simple epiphora acute dacryocystitis Chronic dacryocystitis Ophthalmology RE1-994
spellingShingle	Microbiology Acquired nasolacrimal duct obstruction simple epiphora acute dacryocystitis Chronic dacryocystitis Ophthalmology RE1-994 Pornpanich K Luemsamran P Leelaporn A Santisuk J Tesavibul N Lertsuwanroj B Vangveeravong S Microbiology of primary acquired nasolacrimal duct obstruction: simple epiphora, acute dacryocystitis, and chronic dacryocystitis
description	Kanograt Pornpanich,1 Panitee Luemsamran,1 Amornrut Leelaporn,2 Jiraporn Santisuk,3 Nattaporn Tesavibul,1 Buntitar Lertsuwanroj,1 Sumalee Vangveeravong1 1Department of Ophthalmology, 2Department of Microbiology, 3Eye Surgery Unit, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand Purpose: The aim of this study was to determine the microbiology of primary acquired nasolacrimal duct obstruction (PANDO) and its antimicrobial susceptibilities.Methods: Ninety-three patients (100 eyes) diagnosed with PANDO, categorized as acute, chronic dacryocystitis, or simple epiphora, were prospectively enrolled. Lacrimal sac contents were cultured for aerobic and anaerobic bacteria and fungi. Cultured organisms were identified, and antimicrobial susceptibility testing was performed for aerobic bacteria. Results: Seventy-nine of the 100 samples were culture positive. One hundred twenty-seven organisms were isolated, and 29 different species were identified. Most microorganisms were Gram-positive bacteria (45 samples or 57.0% of all positive culture samples), whereas Gram-negative bacteria, anaerobic bacteria, and fungi were found in 39 (49.4%), 24 (30.4%), and four samples (5.1%), respectively. The most frequently isolated group was coagulase-negative staphylococci (27.8%), followed by nonspore-forming Gram-positive rods (anaerobe) (17.7%) and Pseudomonas aeruginosa (15.2%). Of the 100 samples, five, 45, and 50 samples were obtained from patients with acute dacryocystitis, chronic dacryocystitis, and simple epiphora, respectively. Subgroup analysis showed that Gram-negative organisms were isolated more frequently from the chronic dacryocystitis subgroup than from the simple epiphora subgroup (P=0.012). Antimicrobial susceptibility testing demonstrated that ciprofloxacin was the most effective drug against all Gram-positive and Gram-negative organisms. Conclusion: Patients with PANDO, with or without clinical signs of lacrimal infection, were culture positive. Gram-negative organisms were frequently isolated, which were different from previous studies. Ciprofloxacin was the most effective agent against all Gram-positive and Gram-negative organisms. Keywords: microbiology, acquired nasolacrimal duct obstruction, simple epiphora, acute dacryocystitis, chronic dacryocystitis
format	article
author	Pornpanich K Luemsamran P Leelaporn A Santisuk J Tesavibul N Lertsuwanroj B Vangveeravong S
author_facet	Pornpanich K Luemsamran P Leelaporn A Santisuk J Tesavibul N Lertsuwanroj B Vangveeravong S
author_sort	Pornpanich K
title	Microbiology of primary acquired nasolacrimal duct obstruction: simple epiphora, acute dacryocystitis, and chronic dacryocystitis
title_short	Microbiology of primary acquired nasolacrimal duct obstruction: simple epiphora, acute dacryocystitis, and chronic dacryocystitis
title_full	Microbiology of primary acquired nasolacrimal duct obstruction: simple epiphora, acute dacryocystitis, and chronic dacryocystitis
title_fullStr	Microbiology of primary acquired nasolacrimal duct obstruction: simple epiphora, acute dacryocystitis, and chronic dacryocystitis
title_full_unstemmed	Microbiology of primary acquired nasolacrimal duct obstruction: simple epiphora, acute dacryocystitis, and chronic dacryocystitis
title_sort	microbiology of primary acquired nasolacrimal duct obstruction: simple epiphora, acute dacryocystitis, and chronic dacryocystitis
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/ac8919883edd4ae5b2921a042b9a6d6e
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Microbiology of primary acquired nasolacrimal duct obstruction: simple epiphora, acute dacryocystitis, and chronic dacryocystitis

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