Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia

MDM2 is frequently overexpressed in acute myeloid leukaemia leading to p53 inactivation. Here, the authors are demonstrating that an inhibitor of p53-MDM2 interaction, DS-5272, induce in vivo tumour regression through immune response regulation.

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Autores principales:	Yasutaka Hayashi, Susumu Goyama, XiaoXiao Liu, Moe Tamura, Shuhei Asada, Yosuke Tanaka, Tomofusa Fukuyama, Mark Wunderlich, Eric O’Brien, Benjamin Mizukawa, Satoshi Yamazaki, Akiko Matsumoto, Satoshi Yamasaki, Tatsuhiro Shibata, Koichi Matsuda, Goro Sashida, Hitoshi Takizawa, Toshio Kitamura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ac8963cff5ca454687e5a94c4c01ac79
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spelling	oai:doaj.org-article:ac8963cff5ca454687e5a94c4c01ac792021-12-02T16:58:15ZAntitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia10.1038/s41467-019-12555-12041-1723https://doaj.org/article/ac8963cff5ca454687e5a94c4c01ac792019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12555-1https://doaj.org/toc/2041-1723MDM2 is frequently overexpressed in acute myeloid leukaemia leading to p53 inactivation. Here, the authors are demonstrating that an inhibitor of p53-MDM2 interaction, DS-5272, induce in vivo tumour regression through immune response regulation.Yasutaka HayashiSusumu GoyamaXiaoXiao LiuMoe TamuraShuhei AsadaYosuke TanakaTomofusa FukuyamaMark WunderlichEric O’BrienBenjamin MizukawaSatoshi YamazakiAkiko MatsumotoSatoshi YamasakiTatsuhiro ShibataKoichi MatsudaGoro SashidaHitoshi TakizawaToshio KitamuraNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yasutaka Hayashi Susumu Goyama XiaoXiao Liu Moe Tamura Shuhei Asada Yosuke Tanaka Tomofusa Fukuyama Mark Wunderlich Eric O’Brien Benjamin Mizukawa Satoshi Yamazaki Akiko Matsumoto Satoshi Yamasaki Tatsuhiro Shibata Koichi Matsuda Goro Sashida Hitoshi Takizawa Toshio Kitamura Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia
description	MDM2 is frequently overexpressed in acute myeloid leukaemia leading to p53 inactivation. Here, the authors are demonstrating that an inhibitor of p53-MDM2 interaction, DS-5272, induce in vivo tumour regression through immune response regulation.
format	article
author	Yasutaka Hayashi Susumu Goyama XiaoXiao Liu Moe Tamura Shuhei Asada Yosuke Tanaka Tomofusa Fukuyama Mark Wunderlich Eric O’Brien Benjamin Mizukawa Satoshi Yamazaki Akiko Matsumoto Satoshi Yamasaki Tatsuhiro Shibata Koichi Matsuda Goro Sashida Hitoshi Takizawa Toshio Kitamura
author_facet	Yasutaka Hayashi Susumu Goyama XiaoXiao Liu Moe Tamura Shuhei Asada Yosuke Tanaka Tomofusa Fukuyama Mark Wunderlich Eric O’Brien Benjamin Mizukawa Satoshi Yamazaki Akiko Matsumoto Satoshi Yamasaki Tatsuhiro Shibata Koichi Matsuda Goro Sashida Hitoshi Takizawa Toshio Kitamura
author_sort	Yasutaka Hayashi
title	Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia
title_short	Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia
title_full	Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia
title_fullStr	Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia
title_full_unstemmed	Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia
title_sort	antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ac8963cff5ca454687e5a94c4c01ac79
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Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia

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