Structure based descriptors for the estimation of colloidal interactions and protein aggregation propensities.
The control of protein aggregation is an important requirement in the development of bio-pharmaceutical formulations. Here a simple protein model is proposed that was used in molecular dynamics simulations to obtain a quantitative assessment of the relative contributions of proteins' net-charge...
Guardado en:
Autores principales: | Michael Brunsteiner, Michaela Flock, Bernd Nidetzky |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2013
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Materias: | |
Acceso en línea: | https://doaj.org/article/ac8e65d8ace6427499133004c2aee20a |
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