Electro-catalytic amplified sensor for determination of N-acetylcysteine in the presence of theophylline confirmed by experimental coupled theoretical investigation

Abstract The 1,l/-bis(2-phenylethan-1-ol)ferrocene, 1-butyl-3-methylimidazolium hexafluoro phosphate (BMPF6) and NiO-SWCNTs were used to modify carbon paste electrode (BPOFc/BMPF6/NiO-SWCNTs/CPE), which could act as an electro-catalytic tool for the analysis of N-acetylcysteine in this work. The BPO...

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Autores principales:	Mohsen Keyvanfard, Hassan Karimi-Maleh, Fatemeh Karimi, Francis Opoku, Ephraim Muriithi Kiarii, Poomani Penny Govender, Mehdi Taghavi, Li Fu, Aysenur Aygun, Fatih Sen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ac8fce1ad5f54f0d899cd7e76659f07a
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spelling	oai:doaj.org-article:ac8fce1ad5f54f0d899cd7e76659f07a2021-12-02T14:12:47ZElectro-catalytic amplified sensor for determination of N-acetylcysteine in the presence of theophylline confirmed by experimental coupled theoretical investigation10.1038/s41598-020-79872-02045-2322https://doaj.org/article/ac8fce1ad5f54f0d899cd7e76659f07a2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79872-0https://doaj.org/toc/2045-2322Abstract The 1,l/-bis(2-phenylethan-1-ol)ferrocene, 1-butyl-3-methylimidazolium hexafluoro phosphate (BMPF6) and NiO-SWCNTs were used to modify carbon paste electrode (BPOFc/BMPF6/NiO-SWCNTs/CPE), which could act as an electro-catalytic tool for the analysis of N-acetylcysteine in this work. The BPOFc/BMPF6/NiO-SWCNTs/CPE with high electrical conductivity showed two completely separate signals with oxidation potentials of 432 and 970 mV for the first time that is sufficient for the determination of N-acetylcysteine in the presence of theophylline. The BPOFc/BMPF6/NiO-SWCNTs/CPE showed linear dynamic ranges of 0.02–300.0 μM and 1.0–350.0 μM with the detection limit of ~ 8.0 nM and 0.6 μM for the measurement of N-acetylcysteine and theophylline, respectively. In the second part, understanding the nature of interaction, quantum conductance modulation, electronic properties, charge density, and adsorption behavior of N-acetylcysteine on NiO–SWCNTs surface from first-principle studies through the use of theoretical investigation is vital for designing high-performance sensor materials. The N-acetylcysteine molecule was chemisorbed on the NiO–SWCNTs surface by suitable adsorption energies (− 1.102 to − 5.042 eV) and reasonable charge transfer between N-acetylcysteine and NiO–SWCNTs.Mohsen KeyvanfardHassan Karimi-MalehFatemeh KarimiFrancis OpokuEphraim Muriithi KiariiPoomani Penny GovenderMehdi TaghaviLi FuAysenur AygunFatih SenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mohsen Keyvanfard Hassan Karimi-Maleh Fatemeh Karimi Francis Opoku Ephraim Muriithi Kiarii Poomani Penny Govender Mehdi Taghavi Li Fu Aysenur Aygun Fatih Sen Electro-catalytic amplified sensor for determination of N-acetylcysteine in the presence of theophylline confirmed by experimental coupled theoretical investigation
description	Abstract The 1,l/-bis(2-phenylethan-1-ol)ferrocene, 1-butyl-3-methylimidazolium hexafluoro phosphate (BMPF6) and NiO-SWCNTs were used to modify carbon paste electrode (BPOFc/BMPF6/NiO-SWCNTs/CPE), which could act as an electro-catalytic tool for the analysis of N-acetylcysteine in this work. The BPOFc/BMPF6/NiO-SWCNTs/CPE with high electrical conductivity showed two completely separate signals with oxidation potentials of 432 and 970 mV for the first time that is sufficient for the determination of N-acetylcysteine in the presence of theophylline. The BPOFc/BMPF6/NiO-SWCNTs/CPE showed linear dynamic ranges of 0.02–300.0 μM and 1.0–350.0 μM with the detection limit of ~ 8.0 nM and 0.6 μM for the measurement of N-acetylcysteine and theophylline, respectively. In the second part, understanding the nature of interaction, quantum conductance modulation, electronic properties, charge density, and adsorption behavior of N-acetylcysteine on NiO–SWCNTs surface from first-principle studies through the use of theoretical investigation is vital for designing high-performance sensor materials. The N-acetylcysteine molecule was chemisorbed on the NiO–SWCNTs surface by suitable adsorption energies (− 1.102 to − 5.042 eV) and reasonable charge transfer between N-acetylcysteine and NiO–SWCNTs.
format	article
author	Mohsen Keyvanfard Hassan Karimi-Maleh Fatemeh Karimi Francis Opoku Ephraim Muriithi Kiarii Poomani Penny Govender Mehdi Taghavi Li Fu Aysenur Aygun Fatih Sen
author_facet	Mohsen Keyvanfard Hassan Karimi-Maleh Fatemeh Karimi Francis Opoku Ephraim Muriithi Kiarii Poomani Penny Govender Mehdi Taghavi Li Fu Aysenur Aygun Fatih Sen
author_sort	Mohsen Keyvanfard
title	Electro-catalytic amplified sensor for determination of N-acetylcysteine in the presence of theophylline confirmed by experimental coupled theoretical investigation
title_short	Electro-catalytic amplified sensor for determination of N-acetylcysteine in the presence of theophylline confirmed by experimental coupled theoretical investigation
title_full	Electro-catalytic amplified sensor for determination of N-acetylcysteine in the presence of theophylline confirmed by experimental coupled theoretical investigation
title_fullStr	Electro-catalytic amplified sensor for determination of N-acetylcysteine in the presence of theophylline confirmed by experimental coupled theoretical investigation
title_full_unstemmed	Electro-catalytic amplified sensor for determination of N-acetylcysteine in the presence of theophylline confirmed by experimental coupled theoretical investigation
title_sort	electro-catalytic amplified sensor for determination of n-acetylcysteine in the presence of theophylline confirmed by experimental coupled theoretical investigation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ac8fce1ad5f54f0d899cd7e76659f07a
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Electro-catalytic amplified sensor for determination of N-acetylcysteine in the presence of theophylline confirmed by experimental coupled theoretical investigation

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