Effect of COVID-19 on liver abnormalities: a systematic review and meta‐analysis

Abstract Emerging evidence suggest association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with the development of many liver abnormalities. The overarching aim of this study was therefore to assess the available evidence on the clinical effects of SARS-CoV-2 on the pro...

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Autores principales:	Khalid Bzeizi, Maheeba Abdulla, Nafeesa Mohammed, Jehad Alqamish, Negar Jamshidi, Dieter Broering
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ac912e55ec5f45ba9069a687c807b4ae
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spelling	oai:doaj.org-article:ac912e55ec5f45ba9069a687c807b4ae2021-12-02T15:53:09ZEffect of COVID-19 on liver abnormalities: a systematic review and meta‐analysis10.1038/s41598-021-89513-92045-2322https://doaj.org/article/ac912e55ec5f45ba9069a687c807b4ae2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89513-9https://doaj.org/toc/2045-2322Abstract Emerging evidence suggest association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with the development of many liver abnormalities. The overarching aim of this study was therefore to assess the available evidence on the clinical effects of SARS-CoV-2 on the profiles of liver chemistries and coagulation in COVID-19 diagnosed patients. We considered all study designs including epidemiological and observational that reported liver function test abnormalities in patients confirmed with SARS-CoV-2 infection. Medline, Embase databases and Google Scholar as well as relevant reviews were searched to identify appropriate studies from inception to 31st of August 2020. We calculated the pooled mean with 95% confidence intervals (95% CI) through a random-effect model meta-analysis. A total of 35 studies with 10,692 participants were considered for the review from which 23 studies with sufficient quantitative data were included in the meta-analysis. The pooled mean for liver enzymes and coagulation parameters did not significantly change in patients diagnosed with COVID-19 and remained within normal range. Notwithstanding potential bias from confounding factors in interpretation of data in this review, findings from the observational studies and case reports suggest that COVID-19 does not appear to have a significant impact on the transaminases or total bilirubin levels of patients with confirmed SARS-CoV-2 infection. Further controlled studies and larger sample size observational studies are needed with adequate reporting of other liver function parameters are warranted.Khalid BzeiziMaheeba AbdullaNafeesa MohammedJehad AlqamishNegar JamshidiDieter BroeringNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Khalid Bzeizi Maheeba Abdulla Nafeesa Mohammed Jehad Alqamish Negar Jamshidi Dieter Broering Effect of COVID-19 on liver abnormalities: a systematic review and meta‐analysis
description	Abstract Emerging evidence suggest association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with the development of many liver abnormalities. The overarching aim of this study was therefore to assess the available evidence on the clinical effects of SARS-CoV-2 on the profiles of liver chemistries and coagulation in COVID-19 diagnosed patients. We considered all study designs including epidemiological and observational that reported liver function test abnormalities in patients confirmed with SARS-CoV-2 infection. Medline, Embase databases and Google Scholar as well as relevant reviews were searched to identify appropriate studies from inception to 31st of August 2020. We calculated the pooled mean with 95% confidence intervals (95% CI) through a random-effect model meta-analysis. A total of 35 studies with 10,692 participants were considered for the review from which 23 studies with sufficient quantitative data were included in the meta-analysis. The pooled mean for liver enzymes and coagulation parameters did not significantly change in patients diagnosed with COVID-19 and remained within normal range. Notwithstanding potential bias from confounding factors in interpretation of data in this review, findings from the observational studies and case reports suggest that COVID-19 does not appear to have a significant impact on the transaminases or total bilirubin levels of patients with confirmed SARS-CoV-2 infection. Further controlled studies and larger sample size observational studies are needed with adequate reporting of other liver function parameters are warranted.
format	article
author	Khalid Bzeizi Maheeba Abdulla Nafeesa Mohammed Jehad Alqamish Negar Jamshidi Dieter Broering
author_facet	Khalid Bzeizi Maheeba Abdulla Nafeesa Mohammed Jehad Alqamish Negar Jamshidi Dieter Broering
author_sort	Khalid Bzeizi
title	Effect of COVID-19 on liver abnormalities: a systematic review and meta‐analysis
title_short	Effect of COVID-19 on liver abnormalities: a systematic review and meta‐analysis
title_full	Effect of COVID-19 on liver abnormalities: a systematic review and meta‐analysis
title_fullStr	Effect of COVID-19 on liver abnormalities: a systematic review and meta‐analysis
title_full_unstemmed	Effect of COVID-19 on liver abnormalities: a systematic review and meta‐analysis
title_sort	effect of covid-19 on liver abnormalities: a systematic review and meta‐analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ac912e55ec5f45ba9069a687c807b4ae
work_keys_str_mv	AT khalidbzeizi effectofcovid19onliverabnormalitiesasystematicreviewandmetaanalysis AT maheebaabdulla effectofcovid19onliverabnormalitiesasystematicreviewandmetaanalysis AT nafeesamohammed effectofcovid19onliverabnormalitiesasystematicreviewandmetaanalysis AT jehadalqamish effectofcovid19onliverabnormalitiesasystematicreviewandmetaanalysis AT negarjamshidi effectofcovid19onliverabnormalitiesasystematicreviewandmetaanalysis AT dieterbroering effectofcovid19onliverabnormalitiesasystematicreviewandmetaanalysis
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Effect of COVID-19 on liver abnormalities: a systematic review and meta‐analysis

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