In vitro genotoxic effects of prooxidant therapy

Chronic obstructive pulmonary disease (COPD) is a major problem in industrialized countries. Much evidence suggest that oxidative stress has been associated with chronic diseases, including COPD. There are a number of good experimental and clinical studies clearly showing a strong relationship betwe...

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Autores principales:	O. Yu. Kytikova, T. A. Gvozdenko, T. I. Vitkina, A. D. Novgorodtsev
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2015
Materias:	genotoxicity prooxidant therapy copd Science Q
Acceso en línea:	https://doaj.org/article/ac942ca2090d4ebfb76e45625d3b63a7
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spelling	oai:doaj.org-article:ac942ca2090d4ebfb76e45625d3b63a72021-11-23T06:14:32ZIn vitro genotoxic effects of prooxidant therapy2541-94202587-9596https://doaj.org/article/ac942ca2090d4ebfb76e45625d3b63a72015-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/70https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Chronic obstructive pulmonary disease (COPD) is a major problem in industrialized countries. Much evidence suggest that oxidative stress has been associated with chronic diseases, including COPD. There are a number of good experimental and clinical studies clearly showing a strong relationship between oxidative stress and DNA-damage in several diseases. The present study was aimed at establishing whether genome damage is also exists in COPD. Prooxidant therapy mediates its action through the development of oxidative stress that can lead to oxidative modification of DNA. The role of ozone in the genome damage has received little attention. The genotoxicity of ozone is of interest because ozone therapy is used for the treatment of various chronic conditions, including COPD and may impose a possible risk of genotoxic effects for patients. The purpose of this study was to investigate genotoxic effect of different dosing schedules of prooxidant therapy in vitro on the blood of patients with COPD. Peripheral blood was obtained from 20 COPD patients and 15 age- and sex-matched controls. Our present results have shown that ozone induces DNA-damage in human blood cells in vitro. The severity of oxidative DNA-damage in COPD patients directly depends on the concentration of ozone. Clinical results have shown that DNA-damage is an important part of the pathogenesis of the chronic inflammatory process in the bronchopulmonary system.O. Yu. KytikovaT. A. GvozdenkoT. I. VitkinaA. D. NovgorodtsevScientific Сentre for Family Health and Human Reproduction Problemsarticlegenotoxicityprooxidant therapycopdScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3, Pp 48-51 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	genotoxicity prooxidant therapy copd Science Q
spellingShingle	genotoxicity prooxidant therapy copd Science Q O. Yu. Kytikova T. A. Gvozdenko T. I. Vitkina A. D. Novgorodtsev In vitro genotoxic effects of prooxidant therapy
description	Chronic obstructive pulmonary disease (COPD) is a major problem in industrialized countries. Much evidence suggest that oxidative stress has been associated with chronic diseases, including COPD. There are a number of good experimental and clinical studies clearly showing a strong relationship between oxidative stress and DNA-damage in several diseases. The present study was aimed at establishing whether genome damage is also exists in COPD. Prooxidant therapy mediates its action through the development of oxidative stress that can lead to oxidative modification of DNA. The role of ozone in the genome damage has received little attention. The genotoxicity of ozone is of interest because ozone therapy is used for the treatment of various chronic conditions, including COPD and may impose a possible risk of genotoxic effects for patients. The purpose of this study was to investigate genotoxic effect of different dosing schedules of prooxidant therapy in vitro on the blood of patients with COPD. Peripheral blood was obtained from 20 COPD patients and 15 age- and sex-matched controls. Our present results have shown that ozone induces DNA-damage in human blood cells in vitro. The severity of oxidative DNA-damage in COPD patients directly depends on the concentration of ozone. Clinical results have shown that DNA-damage is an important part of the pathogenesis of the chronic inflammatory process in the bronchopulmonary system.
format	article
author	O. Yu. Kytikova T. A. Gvozdenko T. I. Vitkina A. D. Novgorodtsev
author_facet	O. Yu. Kytikova T. A. Gvozdenko T. I. Vitkina A. D. Novgorodtsev
author_sort	O. Yu. Kytikova
title	In vitro genotoxic effects of prooxidant therapy
title_short	In vitro genotoxic effects of prooxidant therapy
title_full	In vitro genotoxic effects of prooxidant therapy
title_fullStr	In vitro genotoxic effects of prooxidant therapy
title_full_unstemmed	In vitro genotoxic effects of prooxidant therapy
title_sort	in vitro genotoxic effects of prooxidant therapy
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2015
url	https://doaj.org/article/ac942ca2090d4ebfb76e45625d3b63a7
work_keys_str_mv	AT oyukytikova invitrogenotoxiceffectsofprooxidanttherapy AT tagvozdenko invitrogenotoxiceffectsofprooxidanttherapy AT tivitkina invitrogenotoxiceffectsofprooxidanttherapy AT adnovgorodtsev invitrogenotoxiceffectsofprooxidanttherapy
_version_	1718417089815904256

In vitro genotoxic effects of prooxidant therapy

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