Tolerant, Growing Cells from Nutrient Shifts Are Not Persister Cells

ABSTRACT There is much controversy about the metabolic state of cells that are tolerant to antibiotics, known as persister cells. In this opinion piece, we offer an explanation for the discrepancy seen: some laboratories are studying metabolically active and growing cell populations (e.g., as a resu...

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Autores principales:	Jun-Seob Kim, Thomas K. Wood
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	antimicrobial agents persistence tolerance Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/ac9658f524614a788ce887251bff024c
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spelling	oai:doaj.org-article:ac9658f524614a788ce887251bff024c2021-11-15T15:51:00ZTolerant, Growing Cells from Nutrient Shifts Are Not Persister Cells10.1128/mBio.00354-172150-7511https://doaj.org/article/ac9658f524614a788ce887251bff024c2017-05-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00354-17https://doaj.org/toc/2150-7511ABSTRACT There is much controversy about the metabolic state of cells that are tolerant to antibiotics, known as persister cells. In this opinion piece, we offer an explanation for the discrepancy seen: some laboratories are studying metabolically active and growing cell populations (e.g., as a result of nutrient shifts) and attributing the phenotypes that they discern to persister cells while other labs are studying dormant cells. We argue here that the metabolically active cell population should more accurately be considered tolerant cells, while the dormant cells are the true persister population.Jun-Seob KimThomas K. WoodAmerican Society for Microbiologyarticleantimicrobial agentspersistencetoleranceMicrobiologyQR1-502ENmBio, Vol 8, Iss 2 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	antimicrobial agents persistence tolerance Microbiology QR1-502
spellingShingle	antimicrobial agents persistence tolerance Microbiology QR1-502 Jun-Seob Kim Thomas K. Wood Tolerant, Growing Cells from Nutrient Shifts Are Not Persister Cells
description	ABSTRACT There is much controversy about the metabolic state of cells that are tolerant to antibiotics, known as persister cells. In this opinion piece, we offer an explanation for the discrepancy seen: some laboratories are studying metabolically active and growing cell populations (e.g., as a result of nutrient shifts) and attributing the phenotypes that they discern to persister cells while other labs are studying dormant cells. We argue here that the metabolically active cell population should more accurately be considered tolerant cells, while the dormant cells are the true persister population.
format	article
author	Jun-Seob Kim Thomas K. Wood
author_facet	Jun-Seob Kim Thomas K. Wood
author_sort	Jun-Seob Kim
title	Tolerant, Growing Cells from Nutrient Shifts Are Not Persister Cells
title_short	Tolerant, Growing Cells from Nutrient Shifts Are Not Persister Cells
title_full	Tolerant, Growing Cells from Nutrient Shifts Are Not Persister Cells
title_fullStr	Tolerant, Growing Cells from Nutrient Shifts Are Not Persister Cells
title_full_unstemmed	Tolerant, Growing Cells from Nutrient Shifts Are Not Persister Cells
title_sort	tolerant, growing cells from nutrient shifts are not persister cells
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/ac9658f524614a788ce887251bff024c
work_keys_str_mv	AT junseobkim tolerantgrowingcellsfromnutrientshiftsarenotpersistercells AT thomaskwood tolerantgrowingcellsfromnutrientshiftsarenotpersistercells
_version_	1718427420727443456

Tolerant, Growing Cells from Nutrient Shifts Are Not Persister Cells

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