Combination of neuron-specific enolase measurement and initial neurological examination for the prediction of neurological outcomes after cardiac arrest

Abstract This study aimed to investigate the efficacy of the combination of neuron-specific enolase (NSE) measurement and initial neurological examination in predicting the neurological outcomes of patients with cardiac arrest (CA) by retrospectively analyzing data from the Korean Hypothermia Networ...

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Autores principales:	Jae Hoon Lee, Yong Hwan Kim, Jun Ho Lee, Dong Woo Lee, Seong Youn Hwang, Chun Song Youn, Ji-Hoon Kim, Min Seob Sim, Kyung Woon Jeung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ac9b6dd4898a46ddac4383c2e44a5f5a
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spelling	oai:doaj.org-article:ac9b6dd4898a46ddac4383c2e44a5f5a2021-12-02T16:26:37ZCombination of neuron-specific enolase measurement and initial neurological examination for the prediction of neurological outcomes after cardiac arrest10.1038/s41598-021-94555-02045-2322https://doaj.org/article/ac9b6dd4898a46ddac4383c2e44a5f5a2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94555-0https://doaj.org/toc/2045-2322Abstract This study aimed to investigate the efficacy of the combination of neuron-specific enolase (NSE) measurement and initial neurological examination in predicting the neurological outcomes of patients with cardiac arrest (CA) by retrospectively analyzing data from the Korean Hypothermia Network prospective registry. NSE levels were recorded at 48 and 72 h after CA. The initial Full Outline of UnResponsiveness (FOUR) and Glasgow Coma Scale (GCS) scores were recorded. These variables were categorized using the scorecard method. The primary endpoint was poor neurological outcomes at 6 months. Of the 475 patients, 171 (36%) had good neurological outcomes at 6 months. The areas under the curve (AUCs) of the categorized NSE levels at 72 h, GCS score, and FOUR score were 0.889, 0.722, and 0.779, respectively. The AUCs of the combinations of categorized NSE levels at 72 h with categorized GCS scores and FOUR score were 0.910 and 0.912, respectively. Each combination was significantly higher than the AUC value of the categorized NSE level at 72 h alone (with GCS: p = 0.015; with FOUR: p = 0.026). Combining NSE measurement and initial neurological examination improved the prediction of neurological outcomes.Jae Hoon LeeYong Hwan KimJun Ho LeeDong Woo LeeSeong Youn HwangChun Song YounJi-Hoon KimMin Seob SimKyung Woon JeungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jae Hoon Lee Yong Hwan Kim Jun Ho Lee Dong Woo Lee Seong Youn Hwang Chun Song Youn Ji-Hoon Kim Min Seob Sim Kyung Woon Jeung Combination of neuron-specific enolase measurement and initial neurological examination for the prediction of neurological outcomes after cardiac arrest
description	Abstract This study aimed to investigate the efficacy of the combination of neuron-specific enolase (NSE) measurement and initial neurological examination in predicting the neurological outcomes of patients with cardiac arrest (CA) by retrospectively analyzing data from the Korean Hypothermia Network prospective registry. NSE levels were recorded at 48 and 72 h after CA. The initial Full Outline of UnResponsiveness (FOUR) and Glasgow Coma Scale (GCS) scores were recorded. These variables were categorized using the scorecard method. The primary endpoint was poor neurological outcomes at 6 months. Of the 475 patients, 171 (36%) had good neurological outcomes at 6 months. The areas under the curve (AUCs) of the categorized NSE levels at 72 h, GCS score, and FOUR score were 0.889, 0.722, and 0.779, respectively. The AUCs of the combinations of categorized NSE levels at 72 h with categorized GCS scores and FOUR score were 0.910 and 0.912, respectively. Each combination was significantly higher than the AUC value of the categorized NSE level at 72 h alone (with GCS: p = 0.015; with FOUR: p = 0.026). Combining NSE measurement and initial neurological examination improved the prediction of neurological outcomes.
format	article
author	Jae Hoon Lee Yong Hwan Kim Jun Ho Lee Dong Woo Lee Seong Youn Hwang Chun Song Youn Ji-Hoon Kim Min Seob Sim Kyung Woon Jeung
author_facet	Jae Hoon Lee Yong Hwan Kim Jun Ho Lee Dong Woo Lee Seong Youn Hwang Chun Song Youn Ji-Hoon Kim Min Seob Sim Kyung Woon Jeung
author_sort	Jae Hoon Lee
title	Combination of neuron-specific enolase measurement and initial neurological examination for the prediction of neurological outcomes after cardiac arrest
title_short	Combination of neuron-specific enolase measurement and initial neurological examination for the prediction of neurological outcomes after cardiac arrest
title_full	Combination of neuron-specific enolase measurement and initial neurological examination for the prediction of neurological outcomes after cardiac arrest
title_fullStr	Combination of neuron-specific enolase measurement and initial neurological examination for the prediction of neurological outcomes after cardiac arrest
title_full_unstemmed	Combination of neuron-specific enolase measurement and initial neurological examination for the prediction of neurological outcomes after cardiac arrest
title_sort	combination of neuron-specific enolase measurement and initial neurological examination for the prediction of neurological outcomes after cardiac arrest
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ac9b6dd4898a46ddac4383c2e44a5f5a
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Combination of neuron-specific enolase measurement and initial neurological examination for the prediction of neurological outcomes after cardiac arrest

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