Correlation between human leukocyte antigen class II alleles and HAI titers detected post-influenza vaccination.

Influenza is a major cause of morbidity and mortality. Despite vaccination, many elderly recipients do not develop a protective antibody response. To determine whether Human Leukocyte Antigen (HLA) alleles modulate seroprotection to influenza, a cohort of HLA class II-typed high-risk vaccine recipie...

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Autores principales:	Alastair J Moss, Fiona P Gaughran, Aliyye Karasu, Anthony S Gilbert, Alex J Mann, Colin M Gelder, John S Oxford, Henry A Stephens, Rob Lambkin-Williams
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ac9d56ab79864081bf4a5badb10d74f6
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spelling	oai:doaj.org-article:ac9d56ab79864081bf4a5badb10d74f62021-11-18T09:00:26ZCorrelation between human leukocyte antigen class II alleles and HAI titers detected post-influenza vaccination.1932-620310.1371/journal.pone.0071376https://doaj.org/article/ac9d56ab79864081bf4a5badb10d74f62013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23951151/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Influenza is a major cause of morbidity and mortality. Despite vaccination, many elderly recipients do not develop a protective antibody response. To determine whether Human Leukocyte Antigen (HLA) alleles modulate seroprotection to influenza, a cohort of HLA class II-typed high-risk vaccine recipients was investigated. Haemagglutinin inhibition (HAI) titres were measured 14-40 days post-subunit vaccination. Seroprotection was defined as HAI titres reaching 40 or greater for all three vaccine strains. HLA-DRB104∶01 and HLA-DPB104∶01 alleles were detected at higher frequencies in seroprotected compared with non-seroprotected individuals. Thus, the presence of certain HLA class II alleles may determine the magnitude of antibody responses to influenza vaccination.Alastair J MossFiona P GaughranAliyye KarasuAnthony S GilbertAlex J MannColin M GelderJohn S OxfordHenry A StephensRob Lambkin-WilliamsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e71376 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alastair J Moss Fiona P Gaughran Aliyye Karasu Anthony S Gilbert Alex J Mann Colin M Gelder John S Oxford Henry A Stephens Rob Lambkin-Williams Correlation between human leukocyte antigen class II alleles and HAI titers detected post-influenza vaccination.
description	Influenza is a major cause of morbidity and mortality. Despite vaccination, many elderly recipients do not develop a protective antibody response. To determine whether Human Leukocyte Antigen (HLA) alleles modulate seroprotection to influenza, a cohort of HLA class II-typed high-risk vaccine recipients was investigated. Haemagglutinin inhibition (HAI) titres were measured 14-40 days post-subunit vaccination. Seroprotection was defined as HAI titres reaching 40 or greater for all three vaccine strains. HLA-DRB104∶01 and HLA-DPB104∶01 alleles were detected at higher frequencies in seroprotected compared with non-seroprotected individuals. Thus, the presence of certain HLA class II alleles may determine the magnitude of antibody responses to influenza vaccination.
format	article
author	Alastair J Moss Fiona P Gaughran Aliyye Karasu Anthony S Gilbert Alex J Mann Colin M Gelder John S Oxford Henry A Stephens Rob Lambkin-Williams
author_facet	Alastair J Moss Fiona P Gaughran Aliyye Karasu Anthony S Gilbert Alex J Mann Colin M Gelder John S Oxford Henry A Stephens Rob Lambkin-Williams
author_sort	Alastair J Moss
title	Correlation between human leukocyte antigen class II alleles and HAI titers detected post-influenza vaccination.
title_short	Correlation between human leukocyte antigen class II alleles and HAI titers detected post-influenza vaccination.
title_full	Correlation between human leukocyte antigen class II alleles and HAI titers detected post-influenza vaccination.
title_fullStr	Correlation between human leukocyte antigen class II alleles and HAI titers detected post-influenza vaccination.
title_full_unstemmed	Correlation between human leukocyte antigen class II alleles and HAI titers detected post-influenza vaccination.
title_sort	correlation between human leukocyte antigen class ii alleles and hai titers detected post-influenza vaccination.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/ac9d56ab79864081bf4a5badb10d74f6
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Correlation between human leukocyte antigen class II alleles and HAI titers detected post-influenza vaccination.

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